Protein Alignment ATP11C and ATP8B

DIOPT Version :10

• Sequence 1: XP_047297972.1
• Gene: ATP11C / 286410
• HGNCID: 13554
• Length: 1153
• Species: Homo sapiens
• Sequence 2: NP_731669.2
• Gene: ATP8B / 41469
• FlyBaseID: FBgn0037989
• Length: 1726
• Species: Drosophila melanogaster
• Alignment Length: 1507
• Identity: 417/1507 - (27%)
• Similarity: 674/1507 - (44%)
• Gaps: 409/1507 - (27%)

Human     3 VTPSHRSPPA-----RLLELLTDPQI-PEAVCAPSSQCAGEEKRVGTRTVFVGNHPVSETEAYI- 60
            :.|...:||.     :.|....||.: .|:...||.:...:.:|..:...|      ||.|..|
  Fly   139 LAPGGGNPPPNKSDDQELYKQRDPSVTSESKSVPSLRRLSQIRRRRSSYYF------SENERRIR 197

Human    61 -------AQ-RFCDNRIVSSKYTLWNFLPKNLFEQFRRIANFYFLIIFLVQ-VTVDTPTSPVTSG 116
                   || ::.:|.|.:|||:|:.|||.||.|||:|:||||||.:.::| :...:..:|||:.
  Fly   198 ANDKEFNAQFKYHNNYIKTSKYSLFTFLPFNLLEQFQRLANFYFLCLLVLQLIPAISSLTPVTTA 262

Human   117 LPLFFVITVTAIKQGYEDCLRHRADNEVNKSTVYIIENAKRVRKESEKIKVGDVVEVQADETFPC 181
            :||..|:|:||:|..|:|..||.:|::||......:.|.|.|..:..:::||||:.:..::....
  Fly   263 IPLIGVLTLTAVKDAYDDIQRHISDSQVNNRKSKTLRNGKLVEAKWSEVQVGDVIRLDNNQFVAA 327

Human   182 DLILLSSCTTDGTCYVTTASLDGESNCKTHYAVRDTIALCTA-ESIDTLRAAIECEQPQPDLYKF 245
            |.:|||:...:|.|::.||.||||:|.|....:.:||.|... :|:......|.||:|...|.||
  Fly   328 DTLLLSTSEPNGLCFIETAELDGETNLKAKQCLTETIELGDRHDSLWNFNGEIICERPNNLLNKF 392

Human   246 VGRINIYSNSLEAVARSLGPENLLLKGATLKNTEKIYGVAVYTGMETKMALNYQGKSQ-KRSAVE 309
            .|.: |:.....|    |..|.:||:|..|:||:..|||.|:.|::||:..| .||:| |.:.|:
  Fly   393 DGTL-IWRGQRFA----LDNEKILLRGCVLRNTQWCYGVVVFAGVDTKLMQN-SGKTQFKSTGVD 451

Human   310 KSINAFLIVYLFILLTKAAVCTTLKY---VWQSTPYND----EPWYNQKTQKERETLKVLKMFTD 367
            :.:| |:|:.:.:.|  .::|.....   :|:......    .||.:...:....|...:.....
  Fly   452 RLLN-FIIIGIVLFL--VSICALFAIGCAIWEGLIGQHFQLYLPWEHIIPKDYIPTGATVIGLLV 513

Human   368 FLSFMVLFNFIIPVSMYVTVEMQKFLGSFFISWDKDFYDEEINEGALVNTSDLNEELGQVDYVFT 432
            |.|:.::.|.::|:|:||:||:.:|:.||.|:||::.|....|..|...|:.|||||||:.|:|:
  Fly   514 FFSYAIVLNTVVPISLYVSVEVIRFVQSFLINWDEEMYYPTTNTYAKARTTTLNEELGQIQYIFS 578

Human   433 DKTGTLTENSMEFIECCIDGHKYKGV--------------------------------------- 458
            |||||||:|.|.|.:|.|:|..|..|
  Fly   579 DKTGTLTQNIMTFNKCSINGRSYGDVIDLRTGELVEITEQQTIFQNSNTNNRPSPLSGAIVAPPA 643

Human   459 ----------------------------------------------------------------- 458
                                                                             
  Fly   644 APPPIILVHKAEVHAKKTSMVVTSSGEAQVLPDRPRSDIERSAPPMDASEKRPGLKHVRYSAPSR 708

Human   459 TQEVD------------GLS--------------------------------------------- 466
            :|:.|            |||
  Fly   709 SQDADAGRLSPRLDGSGGLSPPVGNEERRISGGFKRSGAGCMQRQLSRTSSCDKVKILHDSQQTE 773

Human   467 -------------------------------------------QTDGTLT--------------- 473
                                                       |:..||:
  Fly   774 THNMHHSSHNRKRLVKIRFKKAPSTATLGVVISQLEHHLDEEPQSTSTLSTTKHHHHRSKAFATN 838

Human   474 ---------------------------YFDKV-------DKNREELFLRALCLCHTVEIKTNDAV 504
                                       ::|:.       |:....:|.|.|.|||||..:|   |
  Fly   839 WSSSPHRVHALQSVDFSANPHHESDFRWYDRTLLDAVRSDEEHSHVFFRLLALCHTVMAET---V 900

Human   505 DGATESAELTYISSSPDEIALVKGAKRYGFTFLGNRNGYMRVENQRKEIEEYELLHTLNFDAVRR 569
            ||     :|.|.:.||||.|||..|:.:||.|.......:.:| ...:.||||||:.|:|:.||:
  Fly   901 DG-----KLEYQAQSPDEAALVSAARNFGFVFRTRTPNSITIE-VMGQTEEYELLNILDFNNVRK 959

Human   570 RMSVIVKTQEGD-ILLFCKGADSAVFPRVQNHEIEL---TKVHVERNAMDGYRTLCVAFKEIAPD 630
            |||||::  .|| ::|:|||||:.::.|:...:.:|   |:.|:.:.|.:|.|||.:|.:.:...
  Fly   960 RMSVILR--RGDSMVLYCKGADNVIYDRLHGGQEDLKARTQDHLNKFAGEGLRTLALAERRLTEQ 1022

Human   631 DYERINRQLIEAKMALQDREEKMEKVFDDIETNMNLIGATAVEDKLQDQAAETIEALHAAGLKVW 695
            .|.....:..||.:::..||:|:..::::||:.|.|:|.||:||||||...::|..|..||:|:|
  Fly  1023 YYNDWRSRQQEAALSMDSREQKLNAIYEEIESEMQLVGVTAIEDKLQDGVPKSIANLQNAGIKIW 1087

Human   696 VLTGDKMETAKSTCYACRLFQTN-TELLELTTKTIEESERKEDRLHELLIEYRKKLLHEF----- 754
            ||||||.|||.:..|:|:|.... .::..:...::||.|::..:..|.:     |:.:.|
  Fly  1088 VLTGDKQETAINIGYSCQLLTDELADVFIVDGNSVEEVEKQLRQFKESI-----KIYNRFRPGGF 1147

Human   755 -------------PKS-----TRSFKK-------------------AWTEHQE------------ 770
                         |.|     |.:|.:                   .|.|..:
  Fly  1148 DPFDRLNSDSNMDPLSVTMTQTSAFMQETNLPPTPPPPPAISVVTFRWDEKNKDNKGGPDSAECN 1212

Human   771 --YG------------LIIDGST-LSLILN--SSQDSSSNNYKSIFLQICMKCTAVLCCRMAPLQ 818
              :|            :::|.:| .:|::|  |.....|...::.||.|..:|.||:|||:.|||
  Fly  1213 NLFGDEKGSEDGGTASIVVDENTGFALVVNGHSLVHCLSPELENKFLDIASQCKAVICCRVTPLQ 1277

Human   819 KAQIVRMVKNLKGSPITLSIGDGANDVSMILESHVGIGIKGKEGRQAARNSDYSVPKFKHLKKLL 883
            ||.:|.::|..|.: :||:|||||||||||..:|:|:||.|:||.||..:||||:.:|::|::||
  Fly  1278 KALVVELIKRAKNA-VTLAIGDGANDVSMIKAAHIGVGISGQEGLQAVLSSDYSIAQFRYLERLL 1341

Human   884 LAHGHLYYVRIAHLVQYFFYKNLCFILPQFLYQFFCGFSQQPLYDAAYLTMYNICFTSLPILAYS 948
            |.||...|.|:...::||||||..|.|....|..|||||.|.::|..::::||:.:||||:||..
  Fly  1342 LVHGRWSYYRMCKFLRYFFYKNFAFTLCHCWYSLFCGFSAQTVFDPMFISVYNLFYTSLPVLALG 1406

Human   949 LLEQHINIDTLTSDPRLYMKISGNAMLQLGPFLYWTFLAAFEGTVFFFGTYFLFQTASLEENGKV 1013
            :.||.::.......||||.....:.:..:..|:|.....||...|.|...|.:::. .:..||.|
  Fly  1407 VFEQDVSDKNSLEFPRLYTPGLKSELFNIREFIYSVLHGAFTSLVLFLIPYGVYKD-GVSANGFV 1470

Human  1014 YG-NWTFGTIVFTVLVFTVTLKLALDTRFWTWINHFVIWGSLAFYVFFSFFWGGII-WPFLKQQR 1076
            .. :.|.|.:|.|:|:...|.:::|.|.:||.:||..|||||.:|....:|:..:| .|::..
  Fly  1471 VSDHMTLGAVVATILIVDNTAQISLYTSYWTVVNHVTIWGSLVWYFVLDYFYNYVIGGPYVGS-- 1533

Human  1077 MYFVFAQMLSSVSTWLAIILLIFISLFPEI-----LL---------IVLKNVRRRSARRNLSCRR 1127
                ..|.:..::.|:.:::.:...:.|.:     ||         |..|::::..:|.:...||
  Fly  1534 ----LTQAMKDLTFWVTMLITVMALVAPVLAYKFYLLDVHPSLSDKIRQKSLKKIHSRASSDVRR 1594

Human  1128 ASDSLSARPSVR 1139
            .:.|...|.|||
  Fly  1595 TASSRRGRRSVR 1606

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP11C	XP_047297972.1	P-type_ATPase_APLT_Dnf-like	66..998	CDD:319770	360/1270 (28%)
		PhoLip_ATPase_C	886..1113	CDD:465071	71/242 (29%)
ATP8B	NP_731669.2	Haloacid Dehalogenase-like Hydrolases	211..>602	CDD:473868	145/399 (36%)
		Haloacid Dehalogenase-like Hydrolases	<885..1456	CDD:473868	203/587 (35%)