Protein Alignment ATP11C and ATP8A

DIOPT Version :10

• Sequence 1: XP_047297972.1
• Gene: ATP11C / 286410
• HGNCID: 13554
• Length: 1153
• Species: Homo sapiens
• Sequence 2: NP_001137651.1
• Gene: ATP8A / 36488
• FlyBaseID: FBgn0259221
• Length: 1350
• Species: Drosophila melanogaster
• Alignment Length: 1132
• Identity: 404/1132 - (35%)
• Similarity: 624/1132 - (55%)
• Gaps: 106/1132 - (9%)

Human    35 AGEEKRVGTRTVFVGNHPVSETEAYIAQRFCDNRIVSSKYTLWNFLPKNLFEQFRRIANFYFLII 99
            ||.:...|.|.:...|.|.       ..::.:|||.::||:..:|||..|||||||.:|.:||:|
  Fly   207 AGYDADDGERRIINLNGPQ-------PTKYGNNRITTAKYSFISFLPAFLFEQFRRYSNCFFLLI 264

Human   100 -FLVQVTVDTPTSPVTSGLPLFFVITVTAIKQGYEDCLRHRADNEVNKSTVYIIENAKRVRKESE 163
             .|.|:...:||...|:.:||.|:::|:|||:..||..|||||||:|..::..:::.........
  Fly   265 AILQQIPEVSPTGRYTTLVPLMFILSVSAIKEIIEDIKRHRADNEINHRSIERLDSGSWCTVRWS 329

Human   164 KIKVGDVVEVQADETFPCDLILLSSCTTDGTCYVTTASLDGESNCKTHYAVRDTIALCTAESIDT 228
            ::.|||:::|..:..||.|||||||......|::.||:||||:|.|...|:..|..|...:.:..
  Fly   330 ELTVGDIIKVGINTFFPADLILLSSSEPQAMCFIETANLDGETNLKIRQALPATAELLETKDLQR 394

Human   229 LRAAIECEQPQPDLYKFVGRINIYSNSLEAVARSLGPENLLLKGATLKNTEKIYGVAVYTGMETK 293
            |...||||.|...||:|.|.:........|    ||.:.:|.:||.|:||..::|:.||:|.|||
  Fly   395 LEGRIECELPNRHLYEFNGVLRETGKPPAA----LGNDQVLQRGAILRNTAWVFGIVVYSGQETK 455

Human   294 MALNYQGKSQKRSAVEKSINAFLIVYLFILLTKAAVCTTLKYVWQSTPYNDEPWYNQKTQKERET 358
            :..|......|||.|:|..|. .|:.||::|....:.:.|..::.:..:::..||...|.
  Fly   456 LMKNSTSAPLKRSTVDKLTNT-QILMLFMILISLCIISGLCNLFWTREHSETDWYLGLTD----- 514

Human   359 LKVLKMFTDFLSFMVLFNFIIPVSMYVTVEMQKFLGSFFISWDKDFYDEEINEGALVNTSDLNEE 423
            .|...:..:.|:|.:|:|.:||:|:.||:|:.:||.:.||::|.:.|.||.|..|:..||:||||
  Fly   515 FKTKSLGYNLLTFFILYNNLIPISLQVTLELVRFLQAIFINYDIEMYHEESNTPAMARTSNLNEE 579

Human   424 LGQVDYVFTDKTGTLTENSMEFIECCIDGHKYKG--------VTQEVDGLSQTDGTLTYFDKVDK 480
            ||.|.|:|:|||||||:|.|||.:|.|.|:.|..        :.|.:.|..:|...:
  Fly   580 LGMVKYIFSDKTGTLTQNVMEFKKCSIAGYVYTAERTPEESQLVQNILGRHETSAVI-------- 636

Human   481 NREELFLRALCLCHTVEIKTNDAVDGATESAELTYISSSPDEIALVKGAKRYGFTFLGNRNGYMR 545
               |.||..|.:||||       :....|:..:.|.::||||.|||:||:::|:.|......|:.
  Fly   637 ---EEFLELLSVCHTV-------IPERKENGNMIYHAASPDERALVEGAQKFGYIFDTRTPKYVE 691

Human   546 VENQRKEIEEYELLHTLNFDAVRRRMSVIVKTQEGDILLFCKGADSAVFPRV--QNHEI-ELTKV 607
            : |.....:.||:|:.|.|.:.|:|||:||:|.|..|.|||||||:.::.|:  |.... |.|..
  Fly   692 I-NALGVRKRYEVLNVLEFTSSRKRMSLIVRTPENKIKLFCKGADTVIYERLAPQGQAFREQTLR 755

Human   608 HVERNAMDGYRTLCVAFKEIAPDDYERINRQLIEAKMALQDREEKMEKVFDDIETNMNLIGATAV 672
            |:|..|.||.||||:|..:|.||.|:..::...:|.:|||:||.|:|...:.||.|:.|:||||:
  Fly   756 HLEEFASDGLRTLCLAVADIRPDVYQEWSQTFDKASVALQNRESKLEDAANLIENNLRLLGATAI 820

Human   673 EDKLQDQAAETIEALHAAGLKVWVLTGDKMETAKSTCYACRLFQTNTELLELTTKTIEESERKED 737
            ||:|||...|||.:|..||:.:|||||||.|||.:..|:|||...:.:::.|.    |||
  Fly   821 EDRLQDGVPETIASLLDAGIYIWVLTGDKQETAINIGYSCRLISHSMDIIILN----EES----- 876

Human   738 RLHELLIEYRKKLLHEFPKSTRSFKKAWTEHQEYGLIIDGSTLSLILNSSQDSSSNNYKSIFLQI 802
                  ::..::::|   :....||.:..:.....|:|||:||...|       |.:.::.|..:
  Fly   877 ------LDATREVIH---RHYGEFKSSSAKDANVALVIDGTTLKYAL-------SCDLRNDFQDL 925

Human   803 CMKCTAVLCCRMAPLQKAQIVRMVKNLKGSPITLSIGDGANDVSMILESHVGIGIKGKEGRQAAR 867
            |:.|..|:|||::|:|||::|.||.. ..:.:||:||||||||:||.:::|||||.|.||.|||.
  Fly   926 CILCRVVICCRVSPMQKAEVVEMVTQ-STNAVTLAIGDGANDVAMIQKANVGIGISGVEGLQAAC 989

Human   868 NSDYSVPKFKHLKKLLLAHGHLYYVRIAHLVQYFFYKNLCFILPQFLYQFFCGFSQQPLYDAAYL 932
            .||||:.:|::|::|||.||...|.||:.|:.|.||||:|..:.:..:..:.|:|.|.|::...:
  Fly   990 ASDYSIAQFRYLQRLLLVHGAWNYARISKLILYSFYKNVCLYVIELWFAVYSGWSGQILFERWTI 1054

Human   933 TMYNICFTSLPILAYSLLEQHINIDTLTSDPRLYMKISGNAML-QLGPFLYWTFLAAFEGTVFFF 996
            .:||:.||::|..|..|.|:....:|:...|.|| |.|.||.| .:..|..|.|.|.......|:
  Fly  1055 GLYNVLFTAMPPFAMGLFEKFCTAETMIRYPMLY-KTSQNAKLFNVKVFWIWIFNALLHSVFLFW 1118

Human   997 GTYFLFQTASLEENGKVYGNWTFGTIVFTVLVFTVTLKLALDTRFWTWINHFVIWGSLAFYVFFS 1061
            .....:....:..:||.......|.:|:|.::.||.||..|.|..|||:.|..||||:..:..|.
  Fly  1119 LPLAAYTKEVIWSDGKTSDYLLMGNLVYTYVIVTVCLKAGLITNSWTWLTHLAIWGSIVLWFGFL 1183

Human  1062 FFWGGIIWPFLKQQRMYFVFA--------QMLSSVSTWLAIILLIFISLFPEILLIVLKN----- 1113
            ..:.. :||..|       ||        |:||:...:..::|:...:|..:::..::.|
  Fly  1184 LIYSH-VWPMFK-------FASNFRGMDIQLLSTPVFYFCLMLVPITTLLIDVICKLVHNTVFKT 1240

Human  1114 ----VRRRSARRN-----LSCRRASDS 1131
                ||....||:     ::..|:|||
  Fly  1241 LTEAVRETEIRRSDISEVMNEPRSSDS 1267

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP11C	XP_047297972.1	P-type_ATPase_APLT_Dnf-like	66..998	CDD:319770	359/944 (38%)
		PhoLip_ATPase_C	886..1113	CDD:465071	68/235 (29%)
ATP8A	NP_001137651.1	P-type_ATPase_APLT_Dnf-like	231..1120	CDD:319770	359/944 (38%)