Protein Alignment ATP11C and CG31729

DIOPT Version :10

• Sequence 1: XP_047297972.1
• Gene: ATP11C / 286410
• HGNCID: 13554
• Length: 1153
• Species: Homo sapiens
• Sequence 2: NP_609634.1
• Gene: CG31729 / 34736
• FlyBaseID: FBgn0051729
• Length: 1256
• Species: Drosophila melanogaster
• Alignment Length: 1157
• Identity: 343/1157 - (29%)
• Similarity: 518/1157 - (44%)
• Gaps: 199/1157 - (17%)

Human    39 KRVGTRTVFVGNHPVSETEAYIAQRFCDNRIVSSKYTLWNFLPKNLFEQFRRIANFYFLIIFLVQ 103
            :.:..|||.:|.   ..||     :|..|.|.:.||....|||..||||||...|.|||::.|.|
  Fly   211 RELRARTVNLGR---VNTE-----KFPPNEIRNQKYNFITFLPLVLFEQFRFFLNLYFLLMALSQ 267

Human   104 VTVDTPTS-PVTSGLPLFFVITVTAIKQGYEDCLRHRADNEVNKSTVYIIENAKRVRK------- 160
            ...|.... |.|...||.||:.||..::..:|..||:.|:|||.      :..||:..
  Fly   268 FIPDIRIGYPYTYWGPLGFVLMVTICREAVDDLRRHQRDHEVNS------QKYKRLSSTNISGYE 326

Human   161 --ESEKIKVGDVVEVQADETFPCDLILLSSCTTDGTCYVTTASLDGESNCKTHYAVRDTIALCTA 223
              .|.|:|||||:.|:.:|..|.|||||.:....|:.:|.|..||||::.|...||..|..|...
  Fly   327 MVPSSKLKVGDVIIVEKNERVPADLILLRTSDRSGSVFVRTDQLDGETDWKPRLAVPYTQKLSRD 391

Human   224 ESIDTLRAAIECEQPQPDLYKFVGRINIYSNSLEAVARSLGPENLLLKGATLKNTEKIYGVAVYT 288
            ..:.::.|:...|:||.|::.|:....:...|.:.   .|..||.|... |:.......|:.:||
  Fly   392 SELHSIDASFYVEKPQNDIHSFIATFCMADGSEDT---GLSVENTLWAN-TVVAAGTATGIVIYT 452

Human   289 GMETKMALNYQGKSQKRSAV---EKSINAFLIVYLFILLTKAAVCTT--LKYVWQSTPYNDEPWY 348
            |.||:..:|   .||.||.|   :..||.         |||...|..  |..|.........|||
  Fly   453 GCETRSVMN---NSQPRSKVGLLDMEING---------LTKVLFCAVLGLSLVMMMLKGFGGPWY 505

Human   349 NQKTQKERETLKVLKMFTDFLSFMVLFNFIIPVSMYVTVEMQKFLGSFFISWDKDFYDEEINEGA 413
            ..             ||    .|::||::|||:|:.|.::|    |..|.||... .|..| :|.
  Fly   506 RY-------------MF----RFVLLFSYIIPISLRVNLDM----GKAFYSWQMQ-NDSNI-QGT 547

Human   414 LVNTSDLNEELGQVDYVFTDKTGTLTENSMEFIECCI-----DGHKYKGVTQEVDGLS-----QT 468
            :|.::.:.||||::.||.||||||||:|.|.|.:..:     |...:..:.|.:..||     |.
  Fly   548 VVRSTTIPEELGRISYVLTDKTGTLTQNEMVFKKIHLGIVSHDADTFHHIGQMIQKLSGNILQQQ 612

Human   469 DGTLTYFDK-VDKNREELF---------------LRALCLCHTV----------EIKTNDAVDGA 507
            .|:|:.... .|..:..:|               :|||.|||.|          .:.|...|.|.
  Fly   613 QGSLSSSSSGGDSTKPMMFGNRMRRPEGWREWEAVRALALCHNVTPVSDDEDNRSVSTASTVTGG 677

Human   508 TES---------------AELTYISSSPDEIALVKGAKRYGFTFLGNRNGYMRVE-----NQRKE 552
            ..|               .|..|.::|||||||||..::.|.|.:......|.::     .....
  Fly   678 NNSPTKSVINIEAPGSTDTEHQYQAASPDEIALVKWTEQVGLTLIARDLNTMTLQVKTPSEDNDI 742

Human   553 IEEYELLHTLNFDAVRRRMSVIVK-TQEGDILLFCKGADSAVFPRVQNHEIELTKVHVERNAMDG 616
            :..|::|....|.:..:||.:||: ::.|.|..:.||||..:...||.:  :.........|.:|
  Fly   743 LLHYQILQLFPFTSESKRMGIIVRESKTGQITFYLKGADVVMSSIVQYN--DWLSEESGNMAREG 805

Human   617 YRTLCVAFKEIAPDDYERINRQLIEAKMALQDREEKMEKVFDDIETNMNLIGATAVEDKLQDQAA 681
            .|||.||.|.:..:.|.....:...|::::.||..|:..|.:.:|..:.|:..|.|||:||:...
  Fly   806 LRTLVVAKKVLTEEQYSDFETRYNAARLSITDRVAKVAAVTESLERELELLCLTGVEDRLQENVR 870

Human   682 ETIEALHAAGLKVWVLTGDKMETAKSTCYACRLFQTNTELLEL-TTKTIEESERKEDRLHELLIE 745
            .|:|.|..||::||:|||||:|||.....:.:|...|..|..| :.||..::       |:.|..
  Fly   871 PTLELLRNAGVRVWMLTGDKLETACCIAKSSQLIGRNQGLHVLRSVKTRTDA-------HQELNS 928

Human   746 YRKKLLHEFPKSTRSFKKAWTEHQEYGLIIDGSTLSLILNSSQDSSSNNYKSIFLQICMKCTAVL 810
            :|:|                   |.:.|:|.|.:|.:.|        ..|:..||::.....||:
  Fly   929 FRRK-------------------QGHALVISGESLEVCL--------QYYRPEFLELATASPAVV 966

Human   811 CCRMAPLQKAQIVRMVKNLKGSPITLSIGDGANDVSMILESHVGIGIKGKEGRQAARNSDYSVPK 875
            |||.:|.||||:|.:::...|.. |.::|||.||||||.::..|:||:|:|||||:...|:|:|:
  Fly   967 CCRCSPTQKAQVVALIQKHTGKR-TCAVGDGGNDVSMIQQADAGVGIEGREGRQASLAGDFSIPQ 1030

Human   876 FKHLKKLLLAHGHLYYVRIAHLVQYFFYKNLCFILPQFLYQFFCGFSQQPLYDAAYLTMYNICFT 940
            |.|:.||||.||...|.|.|.|.|:..::.|.....|.::......|...||....:..|:..:|
  Fly  1031 FSHIAKLLLIHGRRSYKRSAALSQFVIHRGLIITTLQAVFSAVFYLSSVALYQGFLMVGYSTLYT 1095

Human   941 SLPILAYSLLEQHINIDTLTSDPRLYMKISGNAMLQLGPFLYWTFLAAFEGTVFFFGTYFLFQTA 1005
            ..|:.:. :|:|.|..:|..:.|.||..:|....|....|..|..::.::|.|..:|...||...
  Fly  1096 MFPVFSL-VLDQDITSETAVTYPELYKDLSKGRSLSYKTFFIWVLISIYQGGVIMYGALILFVDE 1159

Human  1006 SLEENGKVYGNWTFGTIVFTVLVFTVTLKLALDTRFWTWINHFVIWGSLAFY-----VFFSFFWG 1065
            .:.          ...|.|:.|:.|..:.:||..|.|..:.......|||.|     |...:|..
  Fly  1160 FIH----------IVAISFSALIMTELIMVALTVRTWHRLMVLAELFSLALYLISLAVLHEYFDW 1214

Human  1066 GIIWPFLKQQRMYFVFAQMLSSVSTWLAIILLIFISLFPEILLIVLKNVRRR 1117
            ..||.:           ..|..||      |:..:|..|   |.::|.:|::
  Fly  1215 EFIWSY-----------DFLWKVS------LITLVSCLP---LYIIKFLRKK 1246

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP11C	XP_047297972.1	P-type_ATPase_APLT_Dnf-like	66..998	CDD:319770	308/1004 (31%)
		PhoLip_ATPase_C	886..1113	CDD:465071	54/231 (23%)
CG31729	NP_609634.1	P-type_ATPase_APLT_Neo1-like	230..1177	CDD:319841	315/1039 (30%)
		Cation_ATPase	<704..781	CDD:463817	23/76 (30%)