Protein Alignment ATP11C and CG4301

DIOPT Version :10

• Sequence 1: XP_047297972.1
• Gene: ATP11C / 286410
• HGNCID: 13554
• Length: 1153
• Species: Homo sapiens
• Sequence 2: NP_573125.1
• Gene: CG4301 / 32610
• FlyBaseID: FBgn0030747
• Length: 1342
• Species: Drosophila melanogaster
• Alignment Length: 1314
• Identity: 429/1314 - (32%)
• Similarity: 644/1314 - (49%)
• Gaps: 297/1314 - (22%)

Human    67 NRIVSSKYTLWNFLPKNLFEQFRRIANFYFLIIFLVQVTVDTPTSPVTSGLPLFFVITVTAIKQG 131
            |||.|:||||..|||:||.||||||||||||::.::.:.:|:|.||:||.|||.|||.|||.|||
  Fly    74 NRIKSTKYTLITFLPQNLLEQFRRIANFYFLVMTIISLLIDSPVSPMTSLLPLVFVIAVTAAKQG 138

Human   132 YEDCLRHRADNEVNKSTVYIIENAKRVRKESEKIKVGDVVEVQADETFPCDLILLSSCTTDGTCY 196
            |||.||:|.||.||.|.|.:|.:.|....:|:.:..|:::.|:.|...||||:||.|....|.|:
  Fly   139 YEDILRYRTDNVVNSSPVTVIRDGKEAIIKSQDVIPGELIVVERDCDVPCDLVLLRSTDPHGKCF 203

Human   197 VTTASLDGESNCKTHYAVRD--TIALCTAESIDTLRAAIECEQPQPDLYKFVGRINIYSNSLEAV 259
            :|||:||||||.||....||  |:.|.....:    ..||||.|..|||.|.|:|.:...  |..
  Fly   204 ITTANLDGESNLKTLMVPRDLPTVDLPEMHKL----GIIECESPTTDLYSFNGKIELKGG--EGR 262

Human   260 ARSLGPENLLLKGATLKNTEKIYGVAVYTGMETKMALNYQGKSQKRSAVEKSINAFLIVYLFILL 324
            ...|..||:||:|:.:||||.:.|.||||||.:|:.||.:....|.::.|..||.||||.|..|:
  Fly   263 VLPLSTENVLLRGSRVKNTECVIGCAVYTGMISKLQLNSRLTRNKNASSETYINRFLIVILVALI 327

Human   325 TKAAVCTTLKYVWQSTPYND------EPWYNQKTQKERETLKVLKMFTDFLSFMVLFNFIIPVSM 383
               |:.|.|.::.:   ||:      ..:....|    ::..|.:...|:|||::|||::||:|:
  Fly   328 ---AIVTLLYFLKR---YNELFVIPKLTYLGDAT----DSYSVKQFLQDYLSFLILFNYLIPISL 382

Human   384 YVTVEMQKFLGSFFISWDKDFYDEEINEGALVNTSDLNEELGQVDYVFTDKTGTLTENSMEFIEC 448
            |||:|:|:.:||:|:.||.:.|:.|.::..:||||:|||||||::.:|:|||||||:|.|.|.:|
  Fly   383 YVTIELQRVIGSWFMEWDLELYENETDQPCVVNTSNLNEELGQINILFSDKTGTLTKNEMNFQQC 447

Human   449 CIDGHKYKGVTQEVDGLSQTDGTLTYFDKVDKNREELFLRALCLCHTVEI--------------- 498
            .|:|:|:......::  .:....|...:|...| :.:|.:||.:||||::
  Fly   448 SINGNKFLFKKTRLE--DEETKALLDINKFSAN-QRVFFQALSICHTVQVASGSLEQADAGTAKR 509

Human   499 ----------------------------------------------------------------- 498
                                                                             
  Fly   510 EPVTAIKSGPPEMYSISDITEESHNASQQSELNVGHTIDNSVSAHPNGVNSTIISSDVNPLLVSD 574

Human   499 ---------------------KTNDAVDGA----------------------------------- 507
                                 ::|...:||
  Fly   575 DGYGVERRKRPVVIKRSPNFARSNRMNNGAASDLNINQTDPNTVTNGVEPTTNFRPISLQFRRST 639

Human   508 ---------------------------------------------------TESAE--------- 512
                                                               |.|.|
  Fly   640 SEKDLQQSWEAPSGQAPGHRRAHSYGAPNAYLTNPVTASTPPAGVLFRSPSTTSRESYAAPTFTR 704

Human   513 -----------------------LTYISSSPDEIALVKGAKRYGFTFLGNRNGYMRVE------- 547
                                   |.|.:|||||.|||:.....|..:.|:.:..:||.
  Fly   705 QPTILVRAESQRRKNEIRDFIFTLDYQASSPDEKALVEACANLGMVYTGDDDETLRVRIVPPHMD 769

Human   548 ----NQRKEIEEYELLHTLNFDAVRRRMSVIVKTQEGDILLFCKGADSAVFPRVQNHEIEL---T 605
                ..:...|.::.||.|.|.:.|:||||||:..:|...::.|||:|.|||...|...||   |
  Fly   770 YKRPFAKPREETFQRLHVLEFTSDRKRMSVIVRDTDGKKWIYTKGAESYVFPLCANSSAELVTKT 834

Human   606 KVHVERNAMDGYRTLCVAFKEIAPDDYERINRQLIEAKMALQDREEKMEKVFDDIETNMNLIGAT 670
            ..|:...|..|.|||.:|.:.|:.::|:....:|.:|..:|::|::..|:.:..||:|::|:|||
  Fly   835 DAHISDFARLGLRTLAIARRLISEEEYQDFLVELAQANSSLENRKQLSEECYAKIESNLDLLGAT 899

Human   671 AVEDKLQDQAAETIEALHAAGLKVWVLTGDKMETAKSTCYACRLFQTNTELLELTTKTIEESERK 735
            ||||.|||..|:|:.:|.|||:|:|||||||:|||.:...:|.....:.:...:    :|...|:
  Fly   900 AVEDALQDDVADTLVSLQAAGIKIWVLTGDKVETALNIALSCGHIPPDAKKYFI----MECKNRE 960

Human   736 EDRLHELLIEYRKKLLHEFPKSTRSFKKAWTEHQEYGLIIDGSTLSLILNSSQDSSSNNYKSIFL 800
            |..||  |....::::...             .||..|:|||.:|.:.|   .::||.     |.
  Fly   961 EMLLH--LNALDREIIFGI-------------GQECALLIDGKSLGVAL---AEASSE-----FR 1002

Human   801 QICMKCTAVLCCRMAPLQKAQIVRMVKNLKGSPITLSIGDGANDVSMILESHVGIGIKGKEGRQA 865
            .:.:|||||||||::||||:::|.::|:...:..|.||||||||||||.|:||||||.|:|||||
  Fly  1003 DVAVKCTAVLCCRLSPLQKSEVVSLIKSSNENYNTASIGDGANDVSMIQEAHVGIGIMGREGRQA 1067

Human   866 ARNSDYSVPKFKHLKKLLLAHGHLYYVRIAHLVQYFFYKNLCFILPQFLYQFFCGFSQQPLYDAA 930
            ||.:|::..||..||:|||.|||.:.||::.||.||||||:.|:...||:||...||...:||:.
  Fly  1068 ARCADFAFAKFCMLKRLLLVHGHYHSVRLSLLVLYFFYKNIVFMGIMFLFQFHTLFSSSSVYDSL 1132

Human   931 YLTMYNICFTSLPILAYSLLEQHINIDTLTSDPRLYMKISGNAMLQLGPFLYWTFLAAFEGT-VF 994
            :||:||:.:||||||..::.|:....:.|...|:||.|.:.|..|....||.|...|.:... :|
  Fly  1133 FLTLYNVIYTSLPILFIAISEKPYTEEKLMRTPQLYKKNTDNKQLHWPYFLMWVLFAIYHSVIIF 1197

Human   995 FFGTYFLFQTASLEENGKVYGNWTFGTIVFTVLVFTVTLKLALDTRFWTWINHFVIWGSLAFYVF 1059
            :|...|.:....|...|:......|||::...:|..|.|||.|::.:.::...|.|..|:..:|.
  Fly  1198 YFAFCFFYYNNVLLNYGQTVAFSCFGTLLMWTVVVVVNLKLWLESMYLSFWYIFTIIISILGFVV 1262

Human  1060 FSFFWGGIIWPFLKQQRMYFVFAQMLSSVSTWLAIILLIFISLFPEILLIVLK---NVRRRS--- 1118
            .:..:..|...:  ...:|:.:..:|:|:..||.||:.....|.|:..:.:|:   |::..|
  Fly  1263 TTVIYNVINLDY--DTDIYWAYNNLLASLPVWLWIIVTCVACLVPDYTIRMLQRALNIKSFSIFP 1325

Human  1119 -ARRNLSCRRASDS 1131
             .:|.|..|...:|
  Fly  1326 GKQRKLKMREKFES 1339

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP11C	XP_047297972.1	P-type_ATPase_APLT_Dnf-like	66..998	CDD:319770	396/1172 (34%)
		PhoLip_ATPase_C	886..1113	CDD:465071	73/230 (32%)
CG4301	NP_573125.1	Haloacid Dehalogenase-like Hydrolases	74..1317	CDD:473868	423/1290 (33%)