Protein Alignment ATP11C and CG9981

DIOPT Version :10

• Sequence 1: XP_047297972.1
• Gene: ATP11C / 286410
• HGNCID: 13554
• Length: 1153
• Species: Homo sapiens
• Sequence 2: NP_573124.1
• Gene: CG9981 / 32609
• FlyBaseID: FBgn0030746
• Length: 1060
• Species: Drosophila melanogaster
• Alignment Length: 1094
• Identity: 386/1094 - (35%)
• Similarity: 599/1094 - (54%)
• Gaps: 113/1094 - (10%)

Human    67 NRIVSSKYTLWNFLPKNLFEQFRRIANFYFLIIFLVQVTVDTPTSPVTSGLPLFFVITVTAIKQG 131
            ||:.::|||.:.|||.|.:|||||...||||||.:|...|:...||:.|.|||.||:.:||:|:|
  Fly    28 NRVTTTKYTWFTFLPLNFYEQFRRAVYFYFLIITIVSFFVNETISPLVSLLPLLFVMIITALKEG 92

Human   132 YEDCLRHRADNEVNKSTVYIIENAKRVRKESEKIKVGDVVEVQADETFPCDLILLSSCTTDGTCY 196
            .||..|.::|..||.:.|.:|.|.|.....|:.|..||:|.|:.|...||||:||.|.:.|..|:
  Fly    93 LEDYSRSKSDKLVNTARVTVIRNGKEEIINSQFIVPGDLVVVRNDGDVPCDLVLLQSSSADRKCF 157

Human   197 VTTASLDGESNCKTHYAVRDTIALCTAESIDTLRAAIECEQPQPDLYKFVGRINIYSNSLEAVAR 261
            |.||:||||:|.|| ..|.....|.....:.. :..|.||....|||.|.||:.:.|.: :....
  Fly   158 VNTANLDGETNLKT-ICVPTNYLLAGDHELQG-KDCIVCEPSSADLYTFNGRLELRSGN-DGAGS 219

Human   262 SLGP------ENLLLKGATLKNTEKIYGVAVYTGMETKMALNYQGKSQKRSAVEKSINAFL---- 316
            |.|.      :||||:|..:|:||::.|.|:||||.||:.||.:....|.::.||.||.|:
  Fly   220 SAGDALPLTIDNLLLRGVRVKSTERVVGCAIYTGMHTKLQLNSRYTGNKSASSEKYINRFMVALI 284

Human   317 --------IVYLFILLTKAAVCTTLKYVWQSTPYNDEPWYNQKTQKERETLKVLKMFTDFLSFMV 373
                    ::||.....:|.:..|:.|....|.:| ..|               ::|.|||||::
  Fly   285 VGMIVVVVVLYLIERHKEAKIVPTMPYQGPPTNFN-SAW---------------QIFEDFLSFLL 333

Human   374 LFNFIIPVSMYVTVEMQKFLGSFFISWDKDFYDEEINEGALVNTSDLNEELGQVDYVFTDKTGTL 438
            |||:::|:|.|:.:|:.:..|..|:..|...||||.::...||.|:||||||||:.:|:||||||
  Fly   334 LFNYMVPISAYMNIEVYRIFGMHFMHNDLHLYDEETDQPCRVNASNLNEELGQVNILFSDKTGTL 398

Human   439 TENSMEFIECCIDGHKYKGVTQEVDGLSQT----DGTLTYF--DKVDKNREELFLRALCLCHTVE 497
            |:|.|:|:.|.:.|..|:        |..|    :||...|  :|:|.:...|| .||.:|||||
  Fly   399 TKNLMKFVNCYVPGTNYQ--------LQNTHLVSEGTDEKFELEKLDADAAVLF-EALAVCHTVE 454

Human   498 I------KTNDAVDGATESAEL-------TYISSSPDEIALVKGAKRYGFTFLGNRNGYMRV-EN 548
            :      ||.::.:..:|.:.|       .|.:|||||.||::|....|..:.|..|..:.: ..
  Fly   455 VLQEVGDKTLESSESVSEQSHLMSRNIVDRYQASSPDEKALLEGCASLGLVYEGQENDVLSICRY 519

Human   549 QRKEIEEYELLHTLNFDAVRRRMSVIVKTQEGDILLFCKGADSAVFPRVQ-NHEIELTKVHVERN 612
            ...|..:::.||.|.|.:.|:||||||:.|...|.|:.|||:||:|||.: :..:|.|...:.:.
  Fly   520 PSAEKVQFKRLHVLEFSSERQRMSVIVRDQSDTIWLYSKGAESAIFPRCKASPLVEQTDAQITKY 584

Human   613 AMDGYRTLCVAFKEIAPDD---YERINRQLIEAKMALQDREEKMEKVFDDIETNMNLIGATAVED 674
            |.:|.||:.|..:.:..|:   :|.:.|   :|...|.:|.|.:...::.:|..::|:||||:||
  Fly   585 AQNGLRTMAVGRRMLTDDELFHFEELYR---KANTQLSNRNELIASCYETVENELDLLGATALED 646

Human   675 KLQDQAAETIEALHAAGLKVWVLTGDKMETAKSTCYACRLFQTNTELLELTTKTIEESERKEDRL 739
            .||:...||:|||.|||||:|||||||:|||.:...|||.....:: ......|.|.:|
  Fly   647 ALQEHVGETLEALQAAGLKIWVLTGDKVETAYNIGLACRHIPRGSK-QHFIINTTEPAE------ 704

Human   740 HELLIEYRKKLLHEFPKSTRSFKKAWTEHQEYGLIIDGSTLSLILNSSQDSSSNNYKSIFLQICM 804
               |:.....:..:.|:.               ||:||:|::.:|..:...        |..:.:
  Fly   705 ---LLARLDMIGDDEPEV---------------LIVDGTTITALLEHTPRQ--------FADLAL 743

Human   805 KCTAVLCCRMAPLQKAQIVRMVKNLKGSPITLSIGDGANDVSMILESHVGIGIKGKEGRQAARNS 869
            :|.||||||::||||::||.::|..| ..||.:|||||||||||.|:|:||||.|:||:||||.:
  Fly   744 RCRAVLCCRLSPLQKSEIVTLIKRRK-KYITAAIGDGANDVSMIQEAHIGIGITGREGKQAARCA 807

Human   870 DYSVPKFKHLKKLLLAHGHLYYVRIAHLVQYFFYKNLCFILPQFLYQFFCGFSQQPLYDAAYLTM 934
            |:|:.:|:.|::|.|.|||....|:|.||.::.|||:.......|||.:..:|...:|::.||.:
  Fly   808 DFSIARFEMLRRLFLVHGHYNSQRLAFLVLFYCYKNIIITGCMALYQVYDLYSATNVYNSIYLWL 872

Human   935 YNICFTSLPILAYSLLEQHINIDTLTSDPRLYMKISGNAMLQLGPFLYWTFLAAFEGTVFFFGTY 999
            ::|.:.|......::.::..:.:||.|.|.||..::.|....:|.|..|......:..:.||.||
  Fly   873 FDIVYISFSFTVLAICDKDYSEETLLSHPELYKPLAHNRQASMGVFSLWILNGFVQCFIIFFFTY 937

Human  1000 FLFQTASLEENGKVYGNW-TFGTIVFTVLVFTVTLKLALDTRFWTWINHFVIWGSLAFYVFFSFF 1063
            .:...|::..||....:: ||||::.|::|....|||.|...:.|:.|..:|..|:|.::..::
  Fly   938 AMLNDANVLFNGGQTASFQTFGTMLITIIVIVGNLKLLLVAHYMTYRNFAMILASIAAFMLTTY- 1001

Human  1064 WGGIIWPFLKQQRMYFVFAQMLSSVSTWLAIILLIFISLFPEILLIVLKNVRRR 1117
                ::.......:|.|:.|.|||:..||..|:.....|.|:.::.|:.::.|:
  Fly  1002 ----LYNLYTSGELYDVYNQFLSSLPIWLFTIICSVACLLPDFVIKVVNDMYRK 1051

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP11C	XP_047297972.1	P-type_ATPase_APLT_Dnf-like	66..998	CDD:319770	353/972 (36%)
		PhoLip_ATPase_C	886..1113	CDD:465071	63/227 (28%)
CG9981	NP_573124.1	P-type_ATPase_APLT_Dnf-like	28..936	CDD:319770	353/972 (36%)