DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GPR39 and PK2-R2

DIOPT Version :9

Sequence 1:	NP_001499.1	Gene:	GPR39 / 2863	HGNCID:	4496	Length:	453	Species:	Homo sapiens
Sequence 2:	NP_731788.1	Gene:	PK2-R2 / 41638	FlyBaseID:	FBgn0038139	Length:	599	Species:	Drosophila melanogaster

Alignment Length:	437	Identity:	109/437 - (24%)
Similarity:	175/437 - (40%)	Gaps:	103/437 - (23%)

- Green bases have known domain annotations that are detailed below.

Human    32 TLILVYLIIFVMGLLGNSATIRVTQVLQKKGYLQKEVTDHMVSLACSDILVFLIGMPMEFYSIIW 96
            ||.:.|.:||:.|:|||..|   ..|:.:..::......::.:||.||:::...|||.:.|: :|
  Fly    68 TLSVGYALIFIAGVLGNLIT---CIVISRNNFMHTATNFYLFNLAISDMILLCSGMPQDLYN-LW 128

Human    97 NPLTTSSYTLS---CKLHTFLFEACSYATLLHVLTLSFERYIAICHPFRYKAVSGPCQVKLLIGF 158
            :|   .:|..|   |.|.:.|.|..:.||:|.:...:.|||||||||||...:|...:....|..
  Fly   129 HP---DNYPFSDSICILESVLSETAANATVLTITAFTVERYIAICHPFRQHTMSKLSRAVKFIFA 190

Human   159 VWVTSALVALP-------LLFAMGTEYPLVNVPSHRGLTCNRSSTRHHEQPETSNMSICTNLSSR 216
            :|:.:.|:|||       ::..|||.                                ||..:..
  Fly   191 IWIAALLLALPQAIQFSVVMQGMGTS--------------------------------CTMKNDF 223

Human   217 WT-VFQSSIFGAF------VVYLVVLLSVAFMCWNMMQVLMKSQKGSLAGGTRPPQLRKSESEES 274
            :. ||..|.|..|      :..|.||:.|......::|.|.:          |...:.:..|.::
  Fly   224 FAHVFAVSGFLFFGGPMTAICVLYVLIGVKLKRSRLLQALPR----------RCYDVNRGISAQT 278

Human   275 RTARRQTIIFLRLIVVTLAVCWMPNQIRRIMAAAKPKHDWTRSYFRAYMILLPF-SETFFYLSSV 338
            |..|     .|..:.|...:||.|...:|:||...........:|.....:|.: |...::||:.
  Fly   279 RVIR-----MLVAVAVAFFICWAPFHAQRLMAVYGSTSGIESQWFNDVFSILDYTSGVLYFLSTC 338

Human   339 INPLLYTVSSQQFRRVFVQVLCCRLSLQHANHEK---------------RLRVHAHSTTDSARFV 388
            ||||||.:.|.:||..|...|.....|...|..:               .||:|   ||||.|..
  Fly   339 INPLLYNIMSHKFREAFKVTLARHFGLGGKNQGRGLPHTYSALRRNQTGSLRLH---TTDSVRTT 400

Human   389 QRPL------LFASRRQS-------SARRTEKIFLSTFQSEAEPQSK 422
            ...:      |..|...|       .:.|..::.|.:.|.:.:.:|:
  Fly   401 MTSMATTTTGLNGSANGSGNGTTTGQSVRLNRVSLDSVQMQGQNRSR 447

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GPR39	NP_001499.1	7tmA_GPR39	31..355	CDD:320263	90/340 (26%)
		TM helix 1	31..58	CDD:320263	10/25 (40%)
		TM helix 2	68..94	CDD:320263	8/25 (32%)
		TM helix 3	108..138	CDD:320263	12/29 (41%)
		TM helix 4	150..172	CDD:320263	6/28 (21%)
		TM helix 5	217..246	CDD:320263	9/35 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	255..274		2/18 (11%)
		TM helix 6	276..306	CDD:320263	7/29 (24%)
		TM helix 7	323..348	CDD:320263	10/25 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	415..453		1/8 (13%)
PK2-R2	NP_731788.1	7tm_1	83..344	CDD:278431	78/314 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D380940at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920