Protein Alignment GPR39 and CapaR

DIOPT Version :10

• Sequence 1: NP_001499.1
• Gene: GPR39 / 2863
• HGNCID: 4496
• Length: 453
• Species: Homo sapiens
• Sequence 2: NP_996140.1
• Gene: CapaR / 40393
• FlyBaseID: FBgn0037100
• Length: 477
• Species: Drosophila melanogaster
• Alignment Length: 414
• Identity: 101/414 - (24%)
• Similarity: 190/414 - (45%)
• Gaps: 55/414 - (13%)

Human    31 ITLILVYLIIFVMGLLGNSATIRVTQVLQKKGYLQKEVTDHMVSLACSDILVFLIGMPMEFYSII 95
            :.:.:::..||:.|::||   :.|..|:.:...:......::.|||.||:|..|.|:|.|.: :.
  Fly    69 VLITIIFGGIFITGVVGN---LLVCIVIIRHSAMHTATNYYLFSLAVSDLLYLLFGLPTEVF-LY 129

Human    96 WNPLTTSSYTLSCKLHTFLFEACSYATLLHVLTLSFERYIAICHPFRYKAVSGPCQVKLLIGFVW 160
            |:..........||:..|:.|||:|.::..::..|.||::|||||....|:.|..:...:|..:|
  Fly   130 WHQYPDLFGMPFCKIRAFISEACTYVSVFTIVAFSMERFLAICHPLHLYAMVGFKRAIRIITALW 194

Human   161 VTSALVALPLLFAMGTEYPLVNVPSHRGLTCNRSSTRHHEQPETSNMSICTNLSSRWTVFQSSIF 225
            :.|.:.|:|  |.:.::...:|.|           ..|....|::..|:...:.:...||:.|
  Fly   195 IVSFISAIP--FGLLSDIQYLNYP-----------LDHSRIEESAFCSMSPKIVNEIPVFEVS-- 244

Human   226 GAFVVYLVVLLSVAFMCWNMMQVLMKS---QKGSLAGGTRPPQLRKSESEESRTARRQTII-FLR 286
              |.::.|:.:.:..:.:..|...::|   ||..:..||...:.|.|:      .|::|:| .|.
  Fly   245 --FCIFFVIPMILIILLYGRMGAKIRSRTNQKLGVQQGTNNRETRNSQ------MRKKTVIRMLA 301

Human   287 LIVVTLAVCWMPNQIRRIMAAAKPKHDWTRSYFRAYMILLPFSETFFYLSSVINPLLYTVSSQQF 351
            .:|:|..|||.|..::|::.......|   :|......|...:...:|:|..:||::|:|.|:::
  Fly   302 AVVITFFVCWFPFHLQRLIFLYAKNMD---NYLDINEALFSIAGFAYYVSCTVNPIVYSVMSRRY 363

Human   352 RRVFVQVLCCR---------LSLQHANHEKRL---RVHA-HSTTDSARFVQRPLLFASRRQSSAR 403
            |..|.::||.:         .:..|::..:..   |||: |     .|..|.|..|.: ..|||.
  Fly   364 RVAFRELLCGKAVGAYYNSGFARDHSSFRESSAYDRVHSVH-----VRASQHPNKFET-DSSSAN 422

Human   404 RTEKIFLSTFQSEAEPQSKSQSLS 427
            |.  :...|:.......:.|..||
  Fly   423 RV--LIKKTYSLPLPKNADSTVLS 444

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GPR39	NP_001499.1	7tmA_GPR39	31..355	CDD:320263	81/327 (25%)
		TM helix 1	31..58	CDD:320263	6/26 (23%)
		TM helix 2	68..94	CDD:320263	10/25 (40%)
		TM helix 3	108..138	CDD:320263	11/29 (38%)
		TM helix 4	150..172	CDD:320263	5/21 (24%)
		TM helix 5	217..246	CDD:320263	5/28 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	255..274		4/18 (22%)
		TM helix 6	276..306	CDD:320263	11/30 (37%)
		TM helix 7	323..348	CDD:320263	7/24 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	415..453		3/13 (23%)
CapaR	NP_996140.1	7tmA_capaR	83..367	CDD:320262	78/313 (25%)
		TM helix 2	103..129	CDD:320262	10/26 (38%)
		TM helix 3	142..172	CDD:320262	11/29 (38%)
		TM helix 4	184..206	CDD:320262	6/23 (26%)
		TM helix 5	237..266	CDD:320262	6/32 (19%)
		TM helix 6	291..321	CDD:320262	11/29 (38%)
		TM helix 7	335..360	CDD:320262	7/24 (29%)