Protein Alignment GPR37 and gpr37a

DIOPT Version :10

• Sequence 1: NP_005293.1
• Gene: GPR37 / 2861
• HGNCID: 4494
• Length: 613
• Species: Homo sapiens
• Sequence 2: XP_003201499.2
• Gene: gpr37a / 100537916
• ZFINID: ZDB-GENE-131120-175
• Length: 558
• Species: Danio rerio
• Alignment Length: 521
• Identity: 310/521 - (59%)
• Similarity: 368/521 - (70%)
• Gaps: 42/521 - (8%)

Human   132 ETLGRGNPTALQLFLQISEEEEKGPRGAGISGRSQEQSVKTVPGAS---DLFYWPRRAGK----L 189
            :|||......|.   :.|...:|.|.|...|.|:...|..|...||   :.....:|.||    |
Zfish    41 KTLGHEQRGTLN---KTSYIRDKQPTGVISSTRTAGGSDDTAVTASSRLENIDGMKRIGKTTSFL 102

Human   190 QGSH-HKPLSKTANGLAGHE---GWTIALPGRALAQNGSLGEGIHE----------PGGPRRGNS 240
            ||.| .|...:|......:|   ..:|..|...|.:..||.:.:.:          |..|..|.|
Zfish   103 QGIHKEKQGYQTERATVRNESIMNLSIESPEYVLERVESLPKPVAQVQPTDFHPDFPSIPEWGTS 167

Human   241 -------------TNRRVR---LKNPFYPLTQESYGAYAVMCLSVVIFGTGIIGNLAVMCIVCHN 289
                         .|.|.|   :||||||||.||||||||||:|:..|..||:||:|:|||||||
Zfish   168 PLEEYEEVTAFIPRNTRPRTPGVKNPFYPLTGESYGAYAVMCISIFFFTVGIVGNIAIMCIVCHN 232

Human   290 YYMRSISNSLLANLAFWDFLIIFFCLPLVIFHELTKKWLLEDFSCKIVPYIEVASLGVTTFTLCA 354
            |||||||||||||||.|||:|:|||||||:||||||.|||.:|||||:|||||||||||||||||
Zfish   233 YYMRSISNSLLANLALWDFVILFFCLPLVVFHELTKDWLLGEFSCKIIPYIEVASLGVTTFTLCA 297

Human   355 LCIDRFRAATNVQMYYEMIENCSSTTAKLAVIWVGALLLALPEVVLRQLSKEDLGFSGRAPAERC 419
            |||||||||:||||||||||||:||||||.|||:|||||||||:::|||.||........|.|.|
Zfish   298 LCIDRFRAASNVQMYYEMIENCTSTTAKLTVIWLGALLLALPELLIRQLVKEVSEPPEVTPCEHC 362

Human   420 IIKISPDLPDTIYVLALTYDSARLWWYFGCYFCLPTLFTITCSLVTARKIRKAEKACTRGNKRQI 484
            :::||.|||||:|||.|||:||||||||||||||||||||..|:||||||||||:|..|||::||
Zfish   363 VVRISTDLPDTLYVLGLTYNSARLWWYFGCYFCLPTLFTIISSVVTARKIRKAERASVRGNRKQI 427

Human   485 QLESQMNCTVVALTILYGFCIIPENICNIVTAYMATGVSQQTMDLLNIISQFLLFFKSCVTPVLL 549
            ||||||||.||||.||||||:|||||.|||:.||||||.::|:|:|:::||.:||.||.||||||
Zfish   428 QLESQMNCIVVALAILYGFCVIPENISNIVSVYMATGVPRRTLDILHLVSQMMLFCKSAVTPVLL 492

Human   550 FCLCKPFSRAFMECCCCCCEEC-IQKSSTVTSDDNDNEYTTELELSPFSTI-RREMSTFASVGTH 612
            ..||:|||:||::|||||.||| ..|||...|||||.:.||:|||||:||: ||:.|||...|||
Zfish   493 LALCRPFSKAFLDCCCCCFEECGPPKSSEPNSDDNDQDGTTDLELSPYSTVGRRDASTFPIAGTH 557

Human   613 C 613
            |
Zfish   558 C 558

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GPR37	NP_005293.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	80..138		3/5 (60%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	152..172		6/19 (32%)
		7tmA_GPR37	262..560	CDD:320255	225/297 (76%)
		TM helix 1	263..289	CDD:320255	16/25 (64%)
		TM helix 2	296..322	CDD:320255	21/25 (84%)
		TM helix 3	334..364	CDD:320255	28/29 (97%)
		TM helix 4	377..397	CDD:320255	16/19 (84%)
		TM helix 5	439..464	CDD:320255	21/24 (88%)
		TM helix 6	485..515	CDD:320255	25/29 (86%)
		TM helix 7	528..553	CDD:320255	14/24 (58%)
gpr37a	XP_003201499.2	7tmA_GPR37	205..503	CDD:320255	225/297 (76%)
		TM helix 1	206..232	CDD:320255	16/25 (64%)
		TM helix 2	239..265	CDD:320255	21/25 (84%)
		TM helix 3	277..307	CDD:320255	28/29 (97%)
		TM helix 4	320..340	CDD:320255	16/19 (84%)
		TM helix 5	382..407	CDD:320255	21/24 (88%)
		TM helix 6	428..458	CDD:320255	25/29 (86%)
		TM helix 7	471..496	CDD:320255	14/24 (58%)