DRSC/TRiP Functional Genomics Resources

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Protein Alignment ANK1 and MBP1

DIOPT Version :9

Sequence 1:XP_011542792.1 Gene:ANK1 / 286 HGNCID:492 Length:1969 Species:Homo sapiens
Sequence 2:NP_010227.1 Gene:MBP1 / 851503 SGDID:S000002214 Length:833 Species:Saccharomyces cerevisiae


Alignment Length:927 Identity:185/927 - (19%)
Similarity:323/927 - (34%) Gaps:244/927 - (26%)


- Green bases have known domain annotations that are detailed below.


Human    75 NQGPSA--SAVDLLLRCRISQSTGLLRVLYNQNRKKNGLNGLHLASKEGHVKMV-VELLHKEIIL 136
            ||..||  |.||:.   ....|||.:.    :.:|.:.:|..|:.......|.. ..:|.||::.
Yeast     3 NQIYSARYSGVDVY---EFIHSTGSIM----KRKKDDWVNATHILKAANFAKAKRTRILEKEVLK 60

Human   137 ETTTK--------KG-----NTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENH 188
            ||..|        :|     |.|..:|......:.::.|.::.....:.|.......:.|::.:.
Yeast    61 ETHEKVQGGFGKYQGTWVPLNIAKQLAEKFSVYDQLKPLFDFTQTDGSASPPPAPKHHHASKVDR 125

Human   189 LEVVK-----FLLENGANQNVATEDGF-------TPLAVALQQGHENVVAHLINYGTKGKVRLPA 241
            .:.::     .::|...|...|.|:.|       .|.|...::|..  |.     .|:|..|...
Yeast   126 KKAIRSASTSAIMETKRNNKKAEENQFQSSKILGNPTAAPRKRGRP--VG-----STRGSRRKLG 183

Human   242 LHIAARNDD---TRTAAVLLQNDPN--------PDVLSKTG-FTP----LHIAAH-------YEN 283
            :::.....|   .|.|.      ||        |.:.|..| .:|    |....|       .:|
Yeast   184 VNLQRSQSDMGFPRPAI------PNSSISTTQLPSIRSTMGPQSPTLGILEEERHDSRQQQPQQN 242

Human   284 LNVAQ---LLLNRGASVNFTP---------QN-GITPLHIASRRGNVIMVRLLLDRGAQIETKTK 335
             |.||   :.|..|.|.:..|         || |..|    .::.::|..:........:.:...
Yeast   243 -NSAQFKEIDLEDGLSSDVEPSQQLQQVFNQNTGFVP----QQQSSLIQTQQTESMATSVSSSPS 302

Human   336 DELTPLHCAARNGHVRISEILLDHGAPIQAK-TKNGLSPIHMAAQGDHLDCVRLLLQY------- 392
            ...:|...|..|              |.:.: ...|.|||           :.::.:|       
Yeast   303 LPTSPGDFADSN--------------PFEERFPGGGTSPI-----------ISMIPRYPVTSRPQ 342

Human   393 DAEIDDITLDHLTPL----------------HVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLH 441
            .::|:|....:|:.|                .|..|...|  :...:|....|...     |..|
Yeast   343 TSDINDKVNKYLSKLVDYFISNEMKSNKSLPQVLLHPPPH--SAPYIDAPIDPELH-----TAFH 400

Human   442 IACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPL 506
            .||...::.:.|.|.:.|.||.:....|.|||..:|      :..|...|...|.:..:..||..
Yeast   401 WACSMGNLPIAEALYEAGTSIRSTNSQGQTPLMRSS------LFHNSYTRRTFPRIFQLLHETVF 459

Human   507 -----------HMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNAN 560
                       |:..|...|..|.|.|.   .|.:|.| |.:|.:         .::||| |..:
Yeast   460 DIDSQSQTVIHHIVKRKSTTPSAVYYLD---VVLSKIK-DFSPQY---------RIELLL-NTQD 510

Human   561 PNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDA 625
            .|     |.|.||||::.|.|.....|::..|......|:|.|    |.:....:..:::::...
Yeast   511 KN-----GDTALHIASKNGDVVFFNTLVKMGALTTISNKEGLT----ANEIMNQQYEQMMIQNGT 566

Human   626 HPNAAGKNGLTPLHVAVHHNNL----DIVKLLLPRGGSPHSPAWNGYTPLHIAA--KQNQVEVAR 684
            :.:....|  |.|::.|:.||:    |:..:::.   ||.||:.....|..||.  .:|...|..
Yeast   567 NQHVNSSN--TDLNIHVNTNNIETKNDVNSMVIM---SPVSPSDYITYPSQIATNISRNIPNVVN 626

Human   685 SLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVA 749
            |:.|.....|        .||   ::...|:.:|..:.::......:..|..|.::.:...    
Yeast   627 SMKQMASIYN--------DLH---EQHDNEIKSLQKTLKSISKTKIQVSLKTLEVLKESSK---- 676

Human   750 DVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDI 814
               .::|   :|.|...:..|.........||.|.|::::..:  |.||.|.         .|.:
Yeast   677 ---DENG---EAQTNDDFEILSRLQEQNTKKLRKRLIRYKRLI--KQKLEYR---------QTVL 724

Human   815 VTLLLKN---GASPNEVSSDGTT--PLAIAKRLGYI------SVTDVLKVVTDETSF----VLVS 864
            :..|:::   ..:.|.|..|..|  .|.:|:.|..:      .::.::|...|....    .::.
Yeast   725 LNKLIEDETQATTNNTVEKDNNTLERLELAQELTMLQLQRKNKLSSLVKKFEDNAKIHKYRRIIR 789

Human   865 DKHRMSFPETVDEILDV 881
            :...|:. |.||..|||
Yeast   790 EGTEMNI-EEVDSSLDV 805

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ANK1XP_011542792.1 ANK 47..163 CDD:238125 24/103 (23%)
ANK repeat 47..75 CDD:293786 185/927 (20%)
ANK 108..229 CDD:238125 25/146 (17%)
ANK repeat 109..140 CDD:293786 8/31 (26%)
Ank_2 114..204 CDD:289560 17/108 (16%)
ANK repeat 143..173 CDD:293786 5/34 (15%)
ANK 170..324 CDD:238125 38/201 (19%)
ANK repeat 175..206 CDD:293786 3/35 (9%)
ANK repeat 208..232 CDD:293786 5/30 (17%)
ANK repeat 241..268 CDD:293786 6/37 (16%)
Ank_2 242..333 CDD:289560 24/126 (19%)
ANK 265..390 CDD:238125 26/150 (17%)
ANK repeat 271..301 CDD:293786 11/44 (25%)
ANK repeat 303..334 CDD:293786 4/31 (13%)
Ank_2 308..397 CDD:289560 10/96 (10%)
ANK repeat 336..367 CDD:293786 4/31 (13%)
ANK repeat 369..400 CDD:293786 7/37 (19%)
Ank 402..432 CDD:278452 7/45 (16%)
ANK repeat 405..433 CDD:293786 6/43 (14%)
ANKYR 406..619 CDD:223738 55/239 (23%)
ANK 430..555 CDD:238125 31/135 (23%)
ANK repeat 435..466 CDD:293786 9/30 (30%)
ANK repeat 468..499 CDD:293786 8/30 (27%)
ANK repeat 501..532 CDD:293786 9/41 (22%)
ANK 529..654 CDD:238125 30/128 (23%)
ANK repeat 534..563 CDD:293786 6/28 (21%)
ANK repeat 568..598 CDD:293786 10/29 (34%)
ANK repeat 600..631 CDD:293786 3/30 (10%)
Ank_2 605..696 CDD:289560 20/96 (21%)
ANK repeat 633..661 CDD:293786 8/31 (26%)
ANK repeat 666..697 CDD:293786 8/32 (25%)
ANK 666..695 CDD:197603 7/30 (23%)
ANK 694..819 CDD:238125 20/124 (16%)
ANK repeat 699..730 CDD:293786 4/30 (13%)
Ank_2 704..795 CDD:289560 14/90 (16%)
ANK repeat 732..763 CDD:293786 4/30 (13%)
ANK repeat 765..796 CDD:293786 5/30 (17%)
Ank_5 785..839 CDD:290568 12/58 (21%)
ANK repeat 798..826 CDD:293786 4/30 (13%)
ZU5 984..1088 CDD:128514
Death_ank1 1474..1557 CDD:260067
MBP1NP_010227.1 KilA-N 22..93 CDD:367917 16/74 (22%)
ANKYR 363..544 CDD:223738 50/212 (24%)
ANK repeat 396..425 CDD:293786 9/33 (27%)
ANK repeat 427..510 CDD:293786 25/102 (25%)
ANK repeat 512..543 CDD:293786 11/35 (31%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4177
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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