DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ANK1 and ank1b

DIOPT Version :9

Sequence 1:	XP_011542792.1	Gene:	ANK1 / 286	HGNCID:	492	Length:	1969	Species:	Homo sapiens
Sequence 2:	XP_021329092.1	Gene:	ank1b / 797662	ZFINID:	ZDB-GENE-091113-6	Length:	2091	Species:	Danio rerio

Alignment Length:	2166	Identity:	1343/2166 - (62%)
Similarity:	1558/2166 - (71%)	Gaps:	320/2166 - (14%)

- Green bases have known domain annotations that are detailed below.

Human     1 MAQAAKQLKKIKDIEAQALQEQKEKEESNRKRRNRSRDRKKK----------------------- 42
            |||||||::|.||::..|.||.:||||...|:|||||||::|
Zfish     1 MAQAAKQIRKNKDLQELAAQELREKEEEKIKKRNRSRDRRRKAHVVQRWLVHQDSSLSAEGSSET 65

Human    43 ----------ADAATSFLRAARSGNLDKALDHLRNGVDINTCNQGPSASAVDLLLRCRISQSTGL 97
                      |||.||||||||||||:|||||::||:|||..||
Zfish    66 QGGKWHFDGRADATTSFLRAARSGNLEKALDHIKNGIDINIANQ--------------------- 109

Human    98 LRVLYNQNRKKNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVREL 162
                       ||||||||||||||||||:||||..|.||||||||||||||||||||::||.||
Zfish   110 -----------NGLNGLHLASKEGHVKMVLELLHNGIDLETTTKKGNTALHIAALAGQEKVVAEL 163

Human   163 VNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAH 227
            :||||||||||||||:|||||||||||||||:|||:||||::.|||||||||||||||||||||.
Zfish   164 INYGANVNAQSQKGFSPLYMAAQENHLEVVKYLLEHGANQSLPTEDGFTPLAVALQQGHENVVAL 228

Human   228 LINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLN 292
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||:|||||||
Zfish   229 LINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLSVAQLLLN 293

Human   293 RGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILL 357
            |||:|||||:||||||||||||||||||||||||||||:.|||||||||||||||||||:.||||
Zfish   294 RGANVNFTPKNGITPLHIASRRGNVIMVRLLLDRGAQIDAKTKDELTPLHCAARNGHVRVVEILL 358

Human   358 DHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVL 422
            |.|||:|||||||||||||||||||:||||.||||:||||||||||||||||||||||||:.|||
Zfish   359 DQGAPLQAKTKNGLSPIHMAAQGDHMDCVRQLLQYNAEIDDITLDHLTPLHVAAHCGHHRMVKVL 423

Human   423 LDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKN 487
            ||||||.|:|||||||||||||||||:|.|:||||..||::|||||||||||||:|||||.|||:
Zfish   424 LDKGAKANARALNGFTPLHIACKKNHMRSMDLLLKHSASLEAVTESGLTPLHVAAFMGHLNIVKS 488

Human   488 LLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVK 552
            |||||||||.|||||||||||||||||.|||::||||.|:|:|||||||||||||||:||..:||
Zfish   489 LLQRGASPNASNVKVETPLHMAARAGHCEVAQFLLQNNAQVDAKAKDDQTPLHCAARMGHKELVK 553

Human   553 LLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVA 617
            ||:|:.|||:.|||||||||||||||||.:|...||::.|.|..||||||||||||.|||||.||
Zfish   554 LLMEHKANPDSATTAGHTPLHIAAREGHAQTTRILLDENAQQTKMTKKGFTPLHVACKYGKVDVA 618

Human   618 ELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEV 682
            ||||||.|:||||||||||||||||||||||:||||:.:||||||.|.||||.|||||||||:||
Zfish   619 ELLLERGANPNAAGKNGLTPLHVAVHHNNLDVVKLLVSKGGSPHSTARNGYTALHIAAKQNQLEV 683

Human   683 ARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVP 747
            |.||||||.:||:||:||:||||||:|||..:|||||:|||||.|||||:||||||||||||||.
Zfish   684 ASSLLQYGANANSESLQGITPLHLASQEGQPDMVALLISKQANVNLGNKNGLTPLHLVAQEGHVG 748

Human   748 VADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHT 812
            :||:|:|.|..|.|.:||||||||||.||||||:||||||.||.||:||:|||:|||||||||||
Zfish   749 IADMLVKQGASVYAASRMGYTPLHVACHYGNIKMVKFLLQQQAHVNSKTRLGYTPLHQAAQQGHT 813

Human   813 DIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSDKHRMSFPETVDE 877
            ||||||||:||.|||::::||:||.||||||||||.||||:||:|:..::.::||||||||||||
Zfish   814 DIVTLLLKHGALPNEITTNGTSPLGIAKRLGYISVIDVLKLVTEESVSMITTEKHRMSFPETVDE 878

Human   878 ILDVSEDEGTAHITI-------------------------------------------------- 892
            |||||||||.|.:|:
Zfish   879 ILDVSEDEGVAQLTLGDELLGMDGARYLKLDDLKDQDDDFLSPKKTLRDFESGMGTTNQFSRISV 943

Human   893 --------MGEELISFKAER----RDSRDVDEE-----KELLD---------------------- 918
                    :|:||:.....|    .|.:|.|::     |.|.|
Zfish   944 CDIYFVPYVGDELLGMDGARYLKLDDLKDQDDDFLSPKKTLRDFESGMGTTMSFSSFLFLFLPVS 1008

Human   919 --------FVP---------------KLDQVVE------------------------SPAIPRIP 936
                    |||               |||.:.:                        ||||||||
Zfish  1009 RISVCDIYFVPYVGDELLGMDGARYLKLDDLKDQDDDFLSPKKTLRDFESGMGTTPYSPAIPRIP 1073

Human   937 CAMPETVVIRSEEQEQASKEYDEDSLIPSSPATETSDNISPVASPVHTGFLVSFMVDARGGSMRG 1001
            |..||||::.........||||||||||||||||||||:||||||:|||||||||||||||||||
Zfish  1074 CVSPETVMLDQHTPVPLPKEYDEDSLIPSSPATETSDNVSPVASPIHTGFLVSFMVDARGGSMRG 1138

Human  1002 SRHNGLRVVIPPRTCAAPTRITCRLVKPQKLSTPPPLAEEEGLASRIIALGPTGAQFLSPVIVEI 1066
            ||||||||:||||||||||||||||||||||:|||||.|.||||||||:|||:..|||.||||||
Zfish  1139 SRHNGLRVIIPPRTCAAPTRITCRLVKPQKLTTPPPLVEGEGLASRIISLGPSSMQFLGPVIVEI 1203

Human  1067 PHFASHGRGDRELVVLRSENGSVWKEHRSRYGESYLDQILNGMDEELGSLEELEKKRVCRIITTD 1131
            |||||..|||||||||||||||||||||:|||:..|:.|||||||:|.|.|||||||:.|||:||
Zfish  1204 PHFASLSRGDRELVVLRSENGSVWKEHRNRYGDDVLETILNGMDEDLESQEELEKKRIRRIISTD 1268

Human  1132 FPLYFVIMSRLCQDYDTIGPEGGSLKSKLVPLVQATFPENAVTKRVKLALQAQPVPDELVTKLLG 1196
            |||||.::||:.|:.|.||||||.|.|||||.|||.||:.||||||:|.|||||:||||:|:.||
Zfish  1269 FPLYFAVVSRVRQESDLIGPEGGQLASKLVPQVQAIFPDTAVTKRVRLGLQAQPIPDELLTRQLG 1333

Human  1197 NQATFSPIVTVEPRRRKFHRPIGLRIPLPPSWTDNPRDSGEGDTTSLRLLCSVIGGTDQAQWEDI 1261
            |||||||:||||||||||||||||||||||||.::|||:||||||||||||||||||..||||||
Zfish  1334 NQATFSPVVTVEPRRRKFHRPIGLRIPLPPSWRESPRDAGEGDTTSLRLLCSVIGGTAPAQWEDI 1398

Human  1262 TGTTKLVYANECANFTTNVSARFWLSDCPRTAEAVNFATLLYKELTAVPYMAKFVIFAKMNDPRE 1326
            ||||||:|::.||||||||||||||:|||||||||.||.|||:||.:||||||||:||||||.||
Zfish  1399 TGTTKLMYSHNCANFTTNVSARFWLADCPRTAEAVTFANLLYRELMSVPYMAKFVVFAKMNDARE 1463

Human  1327 GRLRCYCMTDDKVDKTLEQHENFVEVARSRDIEVLEGMSLFAELSGNLVPVKKAAQQ-RSFHFQS 1390
            ||||||||||||:|||||.||||.||||||||||:|||.|..|.|||||||:||.|| |||.||:
Zfish  1464 GRLRCYCMTDDKIDKTLELHENFSEVARSRDIEVMEGMPLHLECSGNLVPVRKATQQPRSFSFQA 1528

Human  1391 FRENRLAMPVKVRDSSREPGGSLSFLRKAMKYEDTQHILCHLNITMPPCAKGSGAEDRRRTPTPL 1455
            ||:|||.:.|||||:::|..|.||||||:.|||||||:||:||||||||.||.|::|||||.|||
Zfish  1529 FRDNRLPVSVKVRDANKEASGFLSFLRKSTKYEDTQHVLCNLNITMPPCVKGVGSDDRRRTLTPL 1593

Human  1456 AL--RYSILSESTPGSLSGTEQAEMKMAVISEHLGLSWAELARELQFSVEDINRIRVENPNSLLE 1518
            ||  |||.|||....:::..|:.|:|:.||:|.|||||.||||||||.|:||||||||||||||:
Zfish  1594 ALRERYSALSEPGLAAVNAMERTELKITVIAEQLGLSWTELARELQFGVDDINRIRVENPNSLLD 1658

Human  1519 QSVALLNLWVIREGQNANMENLYTALQSIDRGEIVNMLEGSGRQSRNLKPDR------RHTDRDY 1577
            ||.|||||||.|||:.|.||:||.||::|||.:||..||.   |:..:.|:.      |..|||.
Zfish  1659 QSSALLNLWVGREGKKAKMESLYGALKNIDRSDIVKCLEA---QAPPVLPETLEEGACRLVDRDS 1720

Human  1578 S-LSPSQMNGYSSLQDELLSPASLGCALSSPLRADQYWNEVAVLDAIPLAATEHDTMLEMSDMQV 1641
            : ||||.:|||..:|:|||||||:..:|.|||..:.||.||:.|:..|:|.||.||||||||:||
Zfish  1721 TLLSPSVVNGYGLVQEELLSPASMQYSLPSPLGVEPYWQEVSSLECAPIATTEEDTMLEMSDVQV 1785

Human  1642 WSAGLTPSLVTAEDSSLE-CSKAEDSD--------------------ATGHEWKLEGALSEEPRG 1685
            |.||::|||||.|||||: .|:|:||:                    |:|...:||....||
Zfish  1786 WPAGVSPSLVTVEDSSLDGSSRADDSEGNTLSLPCSSLGRPSSGASGASGSIMELEEEEEEE--- 1847

Human  1686 PELGSLELVEDD----TVDSDAT-------------NGLIDLLEQEEGQRSEEKLPGSKRQDDAT 1733
                  |:.|||    .|.:.|.             ||      |..|||||     .||.|.|.
Zfish  1848 ------EIEEDDIQHEPVSASAEKAWASGAVPKANYNG------QAGGQRSE-----GKRTDAAA 1895

Human  1734 GA--------------GQDSENEVSLVSGHQRGQARITHSPTVSQVTERSQDRQLFQAPTPRSSG 1784
            |:              |..||.:.|:::|.|. .|::.....:::..|.:.||....|..|.|..
Zfish  1896 GSSMTSVARGGGKAGKGASSEEKFSVLTGQQL-YAQLCERTGLTRSLEHNGDRLGSGAFQPYSQE 1959

Human  1785 LVRLQDWDAD------GSIVSYLQDAAQGSWQEEVTQGPHSFQGTSTMTEGLEPGGSQEYEKVLV 1843
            ...|..|...      .:::|...|..|....:|....|....|.|.:..| ...|:|.::|.|
Zfish  1960 KDSLHSWSQPKPRQTMETMMSSSPDHNQSRVAQEALLTPVCDTGHSEVLRG-RLLGTQPFDKGL- 2022

Human  1844 SVSEHTWTEQPEAESSQADRDRRQQGQEEQVQEAKNTFTQVVQGNEFQNIPGEQVTEEQFTDEQG 1908
                 .::.| |.|....|::||:..:::.|                 ::..:.:.|||||||.|
Zfish  2023 -----GFSHQ-EGELRAWDQERRKAQKDDPV-----------------DLSSDLLHEEQFTDEHG 2064

Human  1909 NIVTK--KIIRKVVRQIDLSS 1927
            |:|||  ..::|.|:.:..||
Zfish  2065 NVVTKLGVDVKKDVQTVKRSS 2085

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ANK1	XP_011542792.1	ANK	47..163	CDD:238125	70/115 (61%)
		ANK repeat	47..75	CDD:293786	22/27 (81%)
		ANK	108..229	CDD:238125	104/120 (87%)
		ANK repeat	109..140	CDD:293786	26/30 (87%)
		Ank_2	114..204	CDD:289560	78/89 (88%)
		ANK repeat	143..173	CDD:293786	25/29 (86%)
		ANK	170..324	CDD:238125	143/153 (93%)
		ANK repeat	175..206	CDD:293786	25/30 (83%)
		ANK repeat	208..232	CDD:293786	22/23 (96%)
		ANK repeat	241..268	CDD:293786	26/26 (100%)
		Ank_2	242..333	CDD:289560	86/90 (96%)
		ANK	265..390	CDD:238125	113/124 (91%)
		ANK repeat	271..301	CDD:293786	27/29 (93%)
		ANK repeat	303..334	CDD:293786	28/30 (93%)
		Ank_2	308..397	CDD:289560	79/88 (90%)
		ANK repeat	336..367	CDD:293786	26/30 (87%)
		ANK repeat	369..400	CDD:293786	27/30 (90%)
		Ank	402..432	CDD:278452	26/29 (90%)
		ANK repeat	405..433	CDD:293786	23/27 (85%)
		ANKYR	406..619	CDD:223738	169/212 (80%)
		ANK	430..555	CDD:238125	102/124 (82%)
		ANK repeat	435..466	CDD:293786	23/30 (77%)
		ANK repeat	468..499	CDD:293786	26/30 (87%)
		ANK repeat	501..532	CDD:293786	24/30 (80%)
		ANK	529..654	CDD:238125	98/124 (79%)
		ANK repeat	534..563	CDD:293786	21/28 (75%)
		ANK repeat	568..598	CDD:293786	18/29 (62%)
		ANK repeat	600..631	CDD:293786	26/30 (87%)
		Ank_2	605..696	CDD:289560	75/90 (83%)
		ANK repeat	633..661	CDD:293786	23/27 (85%)
		ANK repeat	666..697	CDD:293786	24/30 (80%)
		ANK	666..695	CDD:197603	23/28 (82%)
		ANK	694..819	CDD:238125	97/124 (78%)
		ANK repeat	699..730	CDD:293786	23/30 (77%)
		Ank_2	704..795	CDD:289560	69/90 (77%)
		ANK repeat	732..763	CDD:293786	21/30 (70%)
		ANK repeat	765..796	CDD:293786	25/30 (83%)
		Ank_5	785..839	CDD:290568	40/53 (75%)
		ANK repeat	798..826	CDD:293786	24/27 (89%)
		ZU5	984..1088	CDD:128514	92/103 (89%)
		Death_ank1	1474..1557	CDD:260067	58/82 (71%)
ank1b	XP_021329092.1	ANK repeat	80..108	CDD:293786	22/27 (81%)
		ANK	105..230	CDD:238125	107/156 (69%)
		ANK repeat	110..141	CDD:293786	26/30 (87%)
		ANK repeat	144..174	CDD:293786	25/29 (86%)
		ANK repeat	176..207	CDD:293786	25/30 (83%)
		ANK repeat	209..233	CDD:293786	22/23 (96%)
		ANK repeat	242..269	CDD:293786	26/26 (100%)
		ANK	266..391	CDD:238125	113/124 (91%)
		ANK repeat	272..302	CDD:293786	27/29 (93%)
		ANK repeat	304..335	CDD:293786	28/30 (93%)
		ANK repeat	337..367	CDD:293786	25/29 (86%)
		ANK repeat	370..401	CDD:293786	27/30 (90%)
		Ank_4	371..424	CDD:316185	47/52 (90%)
		ANK repeat	403..433	CDD:293786	26/29 (90%)
		ANK	431..556	CDD:238125	102/124 (82%)
		ANK repeat	436..467	CDD:293786	23/30 (77%)
		ANK repeat	469..500	CDD:293786	26/30 (87%)
		ANK repeat	502..533	CDD:293786	24/30 (80%)
		ANK	530..655	CDD:238125	98/124 (79%)
		ANK repeat	535..563	CDD:293786	20/27 (74%)
		ANK repeat	569..599	CDD:293786	18/29 (62%)
		ANK	600..721	CDD:238125	98/120 (82%)
		ANK repeat	601..632	CDD:293786	26/30 (87%)
		ANK repeat	634..662	CDD:293786	23/27 (85%)
		ANK repeat	667..695	CDD:293786	22/27 (81%)
		ANK	695..820	CDD:238125	97/124 (78%)
		ANK repeat	700..731	CDD:293786	23/30 (77%)
		ANK repeat	733..764	CDD:293786	21/30 (70%)
		ANK repeat	766..797	CDD:293786	25/30 (83%)
		ANK repeat	799..827	CDD:293786	24/27 (89%)
		Ank_4	800..852	CDD:316185	41/51 (80%)
		ZU5	1121..1225	CDD:128514	92/103 (89%)
		Death_ank1	1614..1697	CDD:260067	58/82 (71%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	375	1.000	Domainoid score	I5238
eggNOG	1	0.900	-	-		E2759_KOG4177
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H55427
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47562
OrthoDB	1	1.010	-	-		D1011028at2759
OrthoFinder	1	1.000	-	-		FOG0000917
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100012
Panther	1	1.100	-	-	LDO	PTHR24133
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5902
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	1	1.500	-	-
	12	12.290