DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ANK1 and ank1a

DIOPT Version :9

Sequence 1:	XP_011542792.1	Gene:	ANK1 / 286	HGNCID:	492	Length:	1969	Species:	Homo sapiens
Sequence 2:	XP_021331774.1	Gene:	ank1a / 449796	ZFINID:	ZDB-GENE-041010-44	Length:	2033	Species:	Danio rerio

Alignment Length:	2097	Identity:	1378/2097 - (65%)
Similarity:	1587/2097 - (75%)	Gaps:	232/2097 - (11%)

- Green bases have known domain annotations that are detailed below.

Human     1 MAQAAKQLKKIKDIEAQALQEQKEKEESNRKRRNRSRDRKKK----------------------- 42
            ||||||.|:|.||:||.|.||:|||||...|:|:|||::|:|
Zfish     1 MAQAAKHLRKNKDLEALAEQERKEKEEEKSKKRSRSREKKRKAHVVHRWLIDQDNSVSSELPDGQ 65

Human    43 --------ADAATSFLRAARSGNLDKALDHLRNGVDINTCNQGPSASAVDLLLRCRISQSTGLLR 99
                    ||||||||||||||||:|||||::||:||||.||
Zfish    66 GVWHYDETADAATSFLRAARSGNLEKALDHIKNGIDINTANQ----------------------- 107

Human   100 VLYNQNRKKNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVN 164
                     ||||||||||||||||||:||||..|:||||||||||||||||||||::||.||||
Zfish   108 ---------NGLNGLHLASKEGHVKMVLELLHHGIVLETTTKKGNTALHIAALAGQEQVVTELVN 163

Human   165 YGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLI 229
            ||||||||||||||||||||||||||||||||:|||||.:.|||||||||||||||||||||.||
Zfish   164 YGANVNAQSQKGFTPLYMAAQENHLEVVKFLLDNGANQTIPTEDGFTPLAVALQQGHENVVALLI 228

Human   230 NYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRG 294
            |:|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Zfish   229 NHGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRG 293

Human   295 ASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDH 359
            |.|||||:||||||||||||||||||||||||||:|:.||||||||||||||||||||.|||||.
Zfish   294 ADVNFTPKNGITPLHIASRRGNVIMVRLLLDRGAKIDAKTKDELTPLHCAARNGHVRIIEILLDQ 358

Human   360 GAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLD 424
            ||||||||||||||||||||||||||:|.||||:|||||||||||||||||||||||||||||||
Zfish   359 GAPIQAKTKNGLSPIHMAAQGDHLDCIRQLLQYNAEIDDITLDHLTPLHVAAHCGHHRVAKVLLD 423

Human   425 KGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLL 489
            ||||||:|||||||||||||||||:|||:||||..||::||||||||||||:||||||.|||.|:
Zfish   424 KGAKPNTRALNGFTPLHIACKKNHMRVMDLLLKHSASLEAVTESGLTPLHVSSFMGHLNIVKILM 488

Human   490 QRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLL 554
            |:|||||.||||||||||||:||||.|||::||||.|.|:|||||||||||||:|:||..|||||
Zfish   489 QKGASPNASNVKVETPLHMASRAGHCEVAEFLLQNAAPVDAKAKDDQTPLHCASRMGHNEMVKLL 553

Human   555 LENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAEL 619
            ||:.||.|..||||||||||||||||.:|...||:..|....||||||||||||||||||.||.|
Zfish   554 LEHKANSNSTTTAGHTPLHIAAREGHTQTASILLDMNAQLTKMTKKGFTPLHVAAKYGKVDVAVL 618

Human   620 LLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVAR 684
            ||||.|:||||||.|||||||||||||||:|.|||.:||||||.|.|||||||||:||||.|||.
Zfish   619 LLERGANPNAAGKVGLTPLHVAVHHNNLDVVNLLLSKGGSPHSAARNGYTPLHIASKQNQAEVAS 683

Human   685 SLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVA 749
            ||||:|.||||||:|||||||||:|||..:||.||:|||||.||||||||||||||||||||.:|
Zfish   684 SLLQHGASANAESLQGVTPLHLASQEGQPDMVLLLISKQANVNLGNKSGLTPLHLVAQEGHVGIA 748

Human   750 DVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDI 814
            |:|:|||..|.|.|||||||||||.||||||:||||||.||:||.||::.|:|||||||||||||
Zfish   749 DILVKHGASVYAATRMGYTPLHVACHYGNIKMVKFLLQQQANVNCKTRMSYTPLHQAAQQGHTDI 813

Human   815 VTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSDKHRMSFPETVDEIL 879
            ||||||:||.||||:|:||:.||||||||||||.||||:||:||..:..::||||||||||||||
Zfish   814 VTLLLKHGAQPNEVTSNGTSALAIAKRLGYISVIDVLKLVTEETVTMTTTEKHRMSFPETVDEIL 878

Human   880 DVSEDEGTAHITIMGEELISFKAER-----RDSRDVDEE----KELLDFVPKLDQVVESPAIPRI 935
            |||||||.|.:| :||||:..:..|     .|.:|.||:    |::|::..:|:.  .|||||||
Zfish   879 DVSEDEGIAQLT-LGEELLGNEGARYLMKMEDIKDHDEDFLSPKKVLEYEGELEN--HSPAIPRI 940

Human   936 PCAMPETVVIRSEEQEQ------ASKEYDEDSLIPSSPATETSDNISPVASPVHTGFLVSFMVDA 994
            ||..||||:::..|.||      ..||||||||||||||||||||:||||||:||||||||||||
Zfish   941 PCVSPETVMLKEHEMEQQHTPLPLPKEYDEDSLIPSSPATETSDNVSPVASPIHTGFLVSFMVDA 1005

Human   995 RGGSMRGSRHNGLRVVIPPRTCAAPTRITCRLVKPQKLSTPPPLAEEEGLASRIIALGPTGAQFL 1059
            |||||||||||||||:||||||||||||||||||||||.|||||.|.||||||||:|||...|||
Zfish  1006 RGGSMRGSRHNGLRVIIPPRTCAAPTRITCRLVKPQKLPTPPPLVEGEGLASRIISLGPASMQFL 1070

Human  1060 SPVIVEIPHFASHGRGDRELVVLRSENGSVWKEHRSRYGESYLDQILNGMDEELGSLEELEKKRV 1124
            .||||||||||:.||||||||||||||||||||||:|||:..|:.|||||||:|.|.|||.|||:
Zfish  1071 GPVIVEIPHFAALGRGDRELVVLRSENGSVWKEHRNRYGDEVLETILNGMDEDLESQEELGKKRI 1135

Human  1125 CRIITTDFPLYFVIMSRLCQDYDTIGPEGGSLKSKLVPLVQATFPENAVTKRVKLALQAQPVPDE 1189
            .|||:|||||||.::||:.|:.|.||||||.|.|||||:|||||||.||||||:|.|||||||||
Zfish  1136 RRIISTDFPLYFAVVSRIQQENDLIGPEGGFLSSKLVPMVQATFPETAVTKRVRLGLQAQPVPDE 1200

Human  1190 LVTKLLGNQATFSPIVTVEPRRRKFHRPIGLRIPLPPSWTDNPRDSGEGDTTSLRLLCSVIGGTD 1254
            ||.|||||||||||:||||||||||||||||||||||||.::|||:||||||||||||||||||.
Zfish  1201 LVAKLLGNQATFSPVVTVEPRRRKFHRPIGLRIPLPPSWRESPRDAGEGDTTSLRLLCSVIGGTA 1265

Human  1255 QAQWEDITGTTKLVYANECANFTTNVSARFWLSDCPRTAEAVNFATLLYKELTAVPYMAKFVIFA 1319
            .||||||||||||.|:|:||:|||||||||||:|||||||||:||.|||:||:|||||||||:||
Zfish  1266 PAQWEDITGTTKLAYSNDCASFTTNVSARFWLADCPRTAEAVSFANLLYRELSAVPYMAKFVVFA 1330

Human  1320 KMNDPREGRLRCYCMTDDKVDKTLEQHENFVEVARSRDIEVLEGMSLFAELSGNLVPVKKAAQQ- 1383
            |||:.||||||||||||||:||||||||||.||||||||||:|||.|:.|.||||||::|||||
Zfish  1331 KMNEAREGRLRCYCMTDDKMDKTLEQHENFSEVARSRDIEVMEGMPLYLECSGNLVPIRKAAQQP 1395

Human  1384 RSFHFQSFRENRLAMPVKVRDSSREPGGSLSFLRKAMKYEDTQHILCHLNITMPPCAKGSGAEDR 1448
            |.|.||:|::|||.:.|||||||::|.|.||||||:.||||:||:||:||:|||||.|..|:::|
Zfish  1396 RCFSFQAFKDNRLPVSVKVRDSSKDPSGFLSFLRKSTKYEDSQHVLCNLNVTMPPCIKIMGSDER 1460

Human  1449 RRTPTPLAL--RYSILSESTPGSLSGTEQAEMKMAVISEHLGLSWAELARELQFSVEDINRIRVE 1511
            |||.|||||  |||.|:|....|||..|:.|:|||:|:|.||||||||.|||||:|::||:||||
Zfish  1461 RRTLTPLALRERYSALNEPAMASLSAMERTELKMALIAEQLGLSWAELGRELQFNVDEINKIRVE 1525

Human  1512 NPNSLLEQSVALLNLWVIREGQNANMENLYTALQSIDRGEIVNMLEGSG----RQSRNLKPD--- 1569
            |||||||||..|||||..|||:.|.|::||.||:||||.:||||:||.|    .|....:.|
Zfish  1526 NPNSLLEQSSTLLNLWAAREGKRAKMDSLYVALKSIDRVDIVNMMEGQGGPPAGQQGGWEQDASR 1590

Human  1570 RRHTDRDYSLSPSQMNGYS-SLQDELLSPASLGCALSSPLRADQYWNEVAVLDAIPLAATEHDTM 1633
            .||.|||: |||...|||. .:|:||:||||:..:|.|||..:.||.||:.::..|:|.||.||:
Zfish  1591 SRHHDRDH-LSPGITNGYGLVVQEELVSPASMQYSLPSPLGNEPYWQEVSSMECAPIATTEEDTL 1654

Human  1634 LEMSDMQVWSAGLTPSLVTAEDSSLECSKAEDSDA-----TGHEWKLEGALSEEPRGPEL----- 1688
            :|||::|||.:|.:||:|..||||||||.|:||:|     .||      :.|..|.|..|
Zfish  1655 MEMSEVQVWPSGNSPSIVAVEDSSLECSNADDSEALQNRSLGH------SRSGTPGGNGLTPGGL 1713

Human  1689 -GSLELVEDDTV--DSD-ATNGLIDLLE------QEEGQRSEEKLPGSKRQ-------------D 1730
             ||:||:||.::  ||| :..|::.|.|      .:.|||||........|             .
Zfish  1714 SGSIELLEDQSIGADSDYSAAGMLRLSEGVNISALDRGQRSESSEGAVGHQVTNNIKDGSNGGLG 1778

Human  1731 DATGAGQDSENEVSLVSGHQRGQARITHSPTVSQVTERSQDRQLFQAPTPRSSGLVRLQDWDADG 1795
            :..|.|...|:.:||:||.||..||::.||.:.:..:..:||.                   :.|
Zfish  1779 EGGGDGTQLEDSISLISGQQRVYARMSESPGLRRRADPGEDRL-------------------SAG 1824

Human  1796 SIVSYLQDAAQGSWQE--EVTQG-----------------------------------------P 1817
            |.:|||||.....|..  |.||.                                         |
Zfish  1825 SFLSYLQDQGSPGWHSAAEATQNRLASLQCSLPRQAIESMMSSVRATVDSDSKQSCLGQEALIEP 1889

Human  1818 HSFQGTSTMTEGLEPGGSQEYEKVL----VSVSEHTWTEQPEAESSQADRDRRQQGQEEQVQEAK 1878
            ....|.|.:..| ...|:|.:||.|    .:.:..||            .|.|..|
Zfish  1890 VRDMGHSEIIHG-HYQGTQPFEKGLGFPHRTTNMRTW------------EDMRLSG--------- 1932

Human  1879 NTFTQVVQGNEFQNIPGEQVTEEQFTDEQGNIVTKKIIRKVVRQIDLSSADAAQEHEEVTVEGPL 1943
                   ||:|.:::|||||:|||||||.||||||||:|||||:     ....:..:|:.:||..
Zfish  1933 -------QGDEAEDLPGEQVSEEQFTDEHGNIVTKKIVRKVVRR-----GKGEEGGQELIIEGLQ 1985

Human  1944 EDPSELEVDIDYFMKHS 1960
            :|.||.:.|.:.||.::
Zfish  1986 QDISEPDFDGEQFMSYA 2002

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ANK1	XP_011542792.1	ANK	47..163	CDD:238125	71/115 (62%)
		ANK repeat	47..75	CDD:293786	23/27 (85%)
		ANK	108..229	CDD:238125	107/120 (89%)
		ANK repeat	109..140	CDD:293786	26/30 (87%)
		Ank_2	114..204	CDD:289560	81/89 (91%)
		ANK repeat	143..173	CDD:293786	26/29 (90%)
		ANK	170..324	CDD:238125	145/153 (95%)
		ANK repeat	175..206	CDD:293786	27/30 (90%)
		ANK repeat	208..232	CDD:293786	22/23 (96%)
		ANK repeat	241..268	CDD:293786	26/26 (100%)
		Ank_2	242..333	CDD:289560	86/90 (96%)
		ANK	265..390	CDD:238125	115/124 (93%)
		ANK repeat	271..301	CDD:293786	28/29 (97%)
		ANK repeat	303..334	CDD:293786	27/30 (90%)
		Ank_2	308..397	CDD:289560	80/88 (91%)
		ANK repeat	336..367	CDD:293786	28/30 (93%)
		ANK repeat	369..400	CDD:293786	27/30 (90%)
		Ank	402..432	CDD:278452	29/29 (100%)
		ANK repeat	405..433	CDD:293786	26/27 (96%)
		ANKYR	406..619	CDD:223738	170/212 (80%)
		ANK	430..555	CDD:238125	100/124 (81%)
		ANK repeat	435..466	CDD:293786	24/30 (80%)
		ANK repeat	468..499	CDD:293786	24/30 (80%)
		ANK repeat	501..532	CDD:293786	23/30 (77%)
		ANK	529..654	CDD:238125	95/124 (77%)
		ANK repeat	534..563	CDD:293786	21/28 (75%)
		ANK repeat	568..598	CDD:293786	17/29 (59%)
		ANK repeat	600..631	CDD:293786	26/30 (87%)
		Ank_2	605..696	CDD:289560	74/90 (82%)
		ANK repeat	633..661	CDD:293786	22/27 (81%)
		ANK repeat	666..697	CDD:293786	25/30 (83%)
		ANK	666..695	CDD:197603	23/28 (82%)
		ANK	694..819	CDD:238125	99/124 (80%)
		ANK repeat	699..730	CDD:293786	23/30 (77%)
		Ank_2	704..795	CDD:289560	71/90 (79%)
		ANK repeat	732..763	CDD:293786	23/30 (77%)
		ANK repeat	765..796	CDD:293786	25/30 (83%)
		Ank_5	785..839	CDD:290568	40/53 (75%)
		ANK repeat	798..826	CDD:293786	22/27 (81%)
		ZU5	984..1088	CDD:128514	92/103 (89%)
		Death_ank1	1474..1557	CDD:260067	58/82 (71%)
ank1a	XP_021331774.1	ANK repeat	78..106	CDD:293786	23/27 (85%)
		ANK	103..228	CDD:238125	111/156 (71%)
		ANK repeat	108..139	CDD:293786	26/30 (87%)
		ANK repeat	142..172	CDD:293786	26/29 (90%)
		ANK	169..323	CDD:238125	145/153 (95%)
		ANK repeat	174..205	CDD:293786	27/30 (90%)
		ANK repeat	207..231	CDD:293786	22/23 (96%)
		ANK repeat	240..267	CDD:293786	26/26 (100%)
		ANK	264..389	CDD:238125	115/124 (93%)
		ANK repeat	270..300	CDD:293786	28/29 (97%)
		ANK repeat	302..333	CDD:293786	27/30 (90%)
		ANK repeat	335..365	CDD:293786	27/29 (93%)
		ANK repeat	368..399	CDD:293786	27/30 (90%)
		Ank_4	369..422	CDD:316185	49/52 (94%)
		ANK repeat	401..431	CDD:293786	29/29 (100%)
		ANK	429..554	CDD:238125	100/124 (81%)
		ANK repeat	434..465	CDD:293786	24/30 (80%)
		ANK repeat	467..498	CDD:293786	24/30 (80%)
		ANK repeat	500..531	CDD:293786	23/30 (77%)
		ANK	528..653	CDD:238125	95/124 (77%)
		ANK repeat	533..561	CDD:293786	21/27 (78%)
		ANK repeat	567..597	CDD:293786	17/29 (59%)
		ANK repeat	599..630	CDD:293786	26/30 (87%)
		ANK repeat	632..660	CDD:293786	22/27 (81%)
		ANK	664..785	CDD:238125	96/120 (80%)
		ANK repeat	665..696	CDD:293786	25/30 (83%)
		ANK repeat	699..729	CDD:293786	22/29 (76%)
		ANK	726..850	CDD:238125	99/123 (80%)
		ANK repeat	731..762	CDD:293786	23/30 (77%)
		ANK repeat	764..795	CDD:293786	25/30 (83%)
		ANK repeat	797..825	CDD:293786	22/27 (81%)
		ZU5	995..1099	CDD:128514	92/103 (89%)
		Death_ank1	1488..1571	CDD:260067	58/82 (71%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194342505
Domainoid	1	1.000	375	1.000	Domainoid score	I5238
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	2555	1.000	Inparanoid score	I243
NCBI	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47562
OrthoDB	1	1.010	-	-		D1011028at2759
OrthoFinder	1	1.000	-	-		FOG0000917
OrthoInspector	1	1.000	-	-		oto47745
orthoMCL	1	0.900	-	-		OOG6_100012
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5902
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	1	1.500	-	-
	12	12.310