DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ANK1 and Tnks

DIOPT Version :10

Sequence 1:NP_001135918.1 Gene:ANK1 / 286 HGNCID:492 Length:1897 Species:Homo sapiens
Sequence 2:NP_001262963.1 Gene:Tnks / 43095 FlyBaseID:FBgn0027508 Length:1520 Species:Drosophila melanogaster


Alignment Length:1136 Identity:302/1136 - (26%)
Similarity:469/1136 - (41%) Gaps:230/1136 - (20%)


- Green bases have known domain annotations that are detailed below.


Human    45 AATSFLRAARSGNLDKAL--DHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEII-LET 106
            |.:|..||..|.|||..:  |.||.              |..|.|.|.:..|.:|:..:.: ...
  Fly     2 ANSSRSRAILSVNLDAVMANDPLRE--------------LFEACKTGEIAKVKKLITPQTVNARD 52

Human   107 TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQN 171
            |..:.:|.||.||..|:.|||..|:|.||::.|..:.|..||:......|.|||:.||:.||:.|
  Fly    53 TAGRKSTPLHFAAGYGRREVVEFLLNSGASIQACDEGGLHPLHNCCSFGHAEVVRLLLKAGASPN 117

Human   172 VATEDGFTPLAVALQQGHENVVAHLINYGTK------------------------GKVRLPALHI 212
            ......:|||..|..:|..:|...|:.:|..                        |:.|...|..
  Fly   118 TTDNWNYTPLHEAASKGKVDVCLALLQHGANHTIRNSEQKTPLELADEATRPVLTGEYRKDELLE 182

Human   213 AARND-DTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPL 276
            |||:. :.|..|:|...:.|.........||||:||.|..:.:.::||..||.|:...:.|:.||
  Fly   183 AARSGAEDRLLALLTPLNVNCHASDGRRSTPLHLAAGYNRIGIVEILLANGADVHAKDKGGLVPL 247

Human   277 HIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSP 341
            |.|...|:..:.:||:..||.:........||||.||....|.:..:||..||.......:..|.
  Fly   248 HNACSYGHFDVTKLLIQAGANVNANDLWAFTPLHEAASKSRVEVCSLLLSRGADPTLLNCHSKSA 312

Human   342 IHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPN-SRA---- 401
            |..|...:..:  |:..:|                 ..||        |||...|.: |||    
  Fly   313 IDAAPTRELRE--RIAFEY-----------------KGHC--------LLDACRKCDVSRAKKLV 350

Human   402 ----------LNGFTPLHIACKK---NHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIV 453
                      ..|.||||:|...   ...::||||.:.|:.::...::.|||||:|:.:.|...:
  Fly   351 CAEIVNFVHPYTGDTPLHLAVVSPDGKRKQLMELLTRKGSLLNEKNKAFLTPLHLAAELLHYDAM 415

Human   454 KNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNM 518
            :.||::||..|..:...:||||..||  ..:..:.||...|..|..:.:..|    ||::...::
  Fly   416 EVLLKQGAKVNALDSLGQTPLHRCAR--DEQAVRLLLSYAADTNIVSLEGLT----AAQLASDSV 474

Human   519 VKLLLENNANPNLATTAGHTPLHIAAREGHVETVLAL-LEKEASQACMTKKG--FTPLHVAAKYG 580
            :|||    .||    ....|.|..||:.|.::||..: |....|..|....|  .||||.||.:.
  Fly   475 LKLL----KNP----PDSETHLLEAAKAGDLDTVRRIVLNNPISVNCRDLDGRHSTPLHFAAGFN 531

Human   581 KVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPH-SPAWNGYTPLHIAAK 644
            :|.|.:.|||..|...||.|.||.|||.|..:.:.::.:||:..|.:.: |..|. :||||.||.
  Fly   532 RVPVVQFLLEHGAEVYAADKGGLVPLHNACSYGHYEVTELLVKHGANVNVSDLWK-FTPLHEAAA 595

Human   645 QNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGH--AEMV---ALLLSKQANGNLGNKSGL-- 702
            :.:.::.:.||::|.....::..|.||..|..:..|  ||::   :.||.....|||.....|  
  Fly   596 KGKYDICKLLLKHGADPMKKNRDGATPADLVKESDHDVAELLRGPSALLDAAKKGNLARVQRLVT 660

Human   703 --------------TPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFL 753
                          |||||.|...:...|:.|:::|..|:|..:.|..|||.||.||::.:...|
  Fly   661 PESINCRDAQGRNSTPLHLAAGYNNFECAEYLLENGADVNAQDKGGLIPLHNASSYGHLDIAALL 725

Human   754 LQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDV 818
            ::|:..|||..|.|::|||:|||:|.|.:.:|||.:||.....:.:|.||:.:|           
  Fly   726 IKHKTVVNATDKWGFTPLHEAAQKGRTQLCSLLLAHGADAYMKNQEGQTPIELA----------- 779

Human   819 LKVVTDETSFVLVSDKHRMSFPETVDEILDVSEDEGTAHITIMGEELISFKAERRDSRDVDEEKE 883
                                   |.|::..:.:|   |..|.:.::.:|...:...|        
  Fly   780 -----------------------TADDVKCLLQD---AMATSLSQQALSASTQSLTS-------- 810

Human   884 LLDFVPKLDQVVESPAIPRIPCAMPETVVIRSEEQEQASKEYDEDSLIPSSPATETSDNISPVAS 948
                        .|||......|.|.|   .|...........|..|:|:..:...|   .||..
  Fly   811 ------------SSPAPDATAAAAPGT---SSSSSSAILSPTTETVLLPTGASMILS---VPVPL 857

Human   949 PVHTGFLVSFMVDARGGSMRGSRHNGLRVVIPPRTCAAPTRITCRLVKPQKLSTPPPLAEEEGLA 1013
            |:.:...:|   .|:|....|:..:....::|.....  |.:: ..:..|:|.....|.|.|.:.
  Fly   858 PLSSSTRIS---PAQGAEANGAEGSSSDDLLPDADTI--TNVS-GFLSSQQLHHLIELFEREQIT 916

Human  1014 SRIIA---------LGPTGAQFLSPVIVEIPHFAS-HGRG---------------DRELVVLRSE 1053
            ..|:|         :|.:...|...::..|....| .|.|               |:|.|.:..|
  Fly   917 LDILAEMGHDDLKQVGVSAYGFRHKILKGIAQLRSTTGIGNNVNLCTLLVDLLPDDKEFVAVEEE 981

Human  1054 NGSVWKEHR---------SRYGESYLDQILN 1075
            ..:..:|||         :||....:.::.|
  Fly   982 MQATIREHRDNGQAGGYFTRYNIIRVQKVQN 1012

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ANK1NP_001135918.1 ANKYR 1..228 CDD:440430 61/210 (29%)
ANK repeat 47..75 CDD:293786 10/29 (34%)
ANK repeat 77..108 CDD:293786 6/31 (19%)
ANK repeat 111..141 CDD:293786 14/29 (48%)
ANK repeat 143..174 CDD:293786 12/30 (40%)
ANKYR 154..441 CDD:440430 87/329 (26%)
ANK repeat 176..200 CDD:293786 7/23 (30%)
ANK repeat 209..236 CDD:293786 8/27 (30%)
ANK repeat 239..269 CDD:293786 12/29 (41%)
ANK repeat 271..302 CDD:293786 10/30 (33%)
ANK repeat 304..335 CDD:293786 11/30 (37%)
ANKYR 320..606 CDD:440430 87/306 (28%)
ANK repeat 337..368 CDD:293786 5/30 (17%)
ANK repeat 373..401 CDD:293786 7/28 (25%)
ANK repeat 403..434 CDD:293786 11/33 (33%)
ANK repeat 436..467 CDD:293786 12/30 (40%)
ANK repeat 469..500 CDD:293786 10/30 (33%)
ANK repeat 502..531 CDD:293786 8/28 (29%)
ANK repeat 536..566 CDD:293786 10/30 (33%)
ANKYR 552..820 CDD:440430 96/292 (33%)
ANK repeat 568..599 CDD:293786 14/32 (44%)
ANK repeat 601..629 CDD:293786 9/27 (33%)
ANK repeat 634..665 CDD:293786 9/30 (30%)
ANK repeat 667..698 CDD:293786 12/35 (34%)
ANK repeat 700..731 CDD:293786 12/46 (26%)
ANK repeat 733..764 CDD:293786 13/30 (43%)
ANK repeat 766..794 CDD:293786 14/27 (52%)
ZU5 952..1056 CDD:128514 23/128 (18%)
UPA_2 1277..1406 CDD:375346
Death_ank1 1442..1525 CDD:260067
TnksNP_001262963.1 ANKYR 9..330 CDD:440430 97/353 (27%)
ANK repeat 59..87 CDD:293786 14/27 (52%)
ANK repeat 89..120 CDD:293786 12/30 (40%)
ANK repeat 122..153 CDD:293786 8/30 (27%)
ANK repeat 212..240 CDD:293786 12/27 (44%)
ANK repeat 242..273 CDD:293786 10/30 (33%)
ANK repeat 275..306 CDD:293786 11/30 (37%)
ANKYR 334..623 CDD:440430 96/303 (32%)
ANK repeat 363..396 CDD:293786 11/32 (34%)
ANK repeat 398..429 CDD:293786 12/30 (40%)
ANK repeat 431..459 CDD:293786 10/29 (34%)
ANKYR 469..783 CDD:440430 108/356 (30%)
ANK repeat 483..515 CDD:293786 10/31 (32%)
ANK repeat 522..550 CDD:293786 13/27 (48%)
ANK repeat 552..583 CDD:293786 9/30 (30%)
ANK repeat 585..610 CDD:293786 9/25 (36%)
ANK repeat 638..668 CDD:293786 6/29 (21%)
ANK repeat 672..703 CDD:293786 11/30 (37%)
ANK repeat 705..736 CDD:293786 13/30 (43%)
ANK repeat 738..769 CDD:293786 14/30 (47%)
SAM_tankyrase1,2 887..952 CDD:188923 11/67 (16%)
tankyrase_like 948..1170 CDD:238718 13/65 (20%)
Blue background indicates that the domain is not in the aligned region.

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