DRSC/TRiP Functional Genomics Resources

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Protein Alignment ANK1 and Ank2

DIOPT Version :10

Sequence 1:NP_001135918.1 Gene:ANK1 / 286 HGNCID:492 Length:1897 Species:Homo sapiens
Sequence 2:NP_001189070.1 Gene:Ank2 / 38863 FlyBaseID:FBgn0261788 Length:13559 Species:Drosophila melanogaster


Alignment Length:1978 Identity:854/1978 - (43%)
Similarity:1201/1978 - (60%) Gaps:204/1978 - (10%)


- Green bases have known domain annotations that are detailed below.


Human    42 KADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILET 106
            :.|..||||||||:|||::.|:||:|.:||||.|.||||.||||||:||:.:|.|||.:..|:::
  Fly     8 QGDGNTSFLRAARAGNLERVLEHLKNNIDINTSNANGLNALHLASKDGHIHVVSELLRRGAIVDS 72

Human   107 TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQN 171
            .|||||||||||:||||:|||:.|:.:.|:||.|||.|||||||||||||..||:.||.|||||:
  Fly    73 ATKKGNTALHIASLAGQEEVVKLLLEHNASVNVQSQNGFTPLYMAAQENHDAVVRLLLSNGANQS 137

Human   172 VATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLS 236
            :||||||||||||:||||:.|||.|:...|:||||||||||||:.||.:.|.:||.||.||||.|
  Fly   138 LATEDGFTPLAVAMQQGHDKVVAVLLESDTRGKVRLPALHIAAKKDDVKAATLLLDNDHNPDVTS 202

Human   237 KTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETK 301
            |:||||||||:||.|.|:|.||:.:||.||::.::.|:|||:|::.|...||.|||::|..||.|
  Fly   203 KSGFTPLHIASHYGNQNIANLLIQKGADVNYSAKHNISPLHVAAKWGKTNMVSLLLEKGGNIEAK 267

Human   302 TKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDD 366
            |:|.|||||||||:||.::.::||:.||||.|||||||:|:||||||:|:|..|:||.:.|.:|:
  Fly   268 TRDGLTPLHCAARSGHEQVVDMLLERGAPISAKTKNGLAPLHMAAQGEHVDAARILLYHRAPVDE 332

Human   367 ITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASID 431
            :|:|:||.|||||||||.||||:|||:.|..|:||||||||||||||||.::|:||||:.||||.
  Fly   333 VTVDYLTALHVAAHCGHVRVAKLLLDRNADANARALNGFTPLHIACKKNRLKVVELLLRHGASIS 397

Human   432 AVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKV 496
            |.|||||||||||:|||.:.||..|||..|||:|..|:.|||||:||||..|::.:.||:|.|:|
  Fly   398 ATTESGLTPLHVAAFMGCMNIVIYLLQHDASPDVPTVRGETPLHLAARANQTDIIRILLRNGAQV 462

Human   497 NAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEAS 561
            :|:|::.|||||.|:|:|:.::|.|||::.|..:..|...:|.|||||:||..|....|:|..|:
  Fly   463 DARAREQQTPLHIASRLGNVDIVMLLLQHGAQVDATTKDMYTALHIAAKEGQDEVAAVLIENGAA 527

Human   562 QACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGG 626
            ....|||||||||:.||||.::||:|||:::|..:|.||||:||||||.|:||..:..|||.:|.
  Fly   528 LDAATKKGFTPLHLTAKYGHIKVAQLLLQKEADVDAQGKNGVTPLHVACHYNNQQVALLLLEKGA 592

Human   627 SPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQ 691
            |||:.|.||:|||||||::||:::|.:||:||..|||||..|.|||||::||||||:..||:..:
  Fly   593 SPHATAKNGHTPLHIAARKNQMDIATTLLEYGALANAESKAGFTPLHLSSQEGHAEISNLLIEHK 657

Human   692 ANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQH 756
            |..|...|:||||:||.|||.:|.||::|.|:|..:|..|:.||||||||||:|...:|:||||:
  Fly   658 AAVNHPAKNGLTPMHLCAQEDNVNVAEILEKNGANIDMATKAGYTPLHVASHFGQANMVRFLLQN 722

Human   757 QADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKV 821
            .|:|:|.|.:||:||||.|||||..||.|||::.|:.|..:.:|.|||.||::||||||.|.||.
  Fly   723 GANVDAATSIGYTPLHQTAQQGHCHIVNLLLEHKANANAQTVNGQTPLHIARKLGYISVLDSLKT 787

Human   822 VT--DETSFV--LVSDKHRMSFPETVDE-ILDVSEDEG----------TAHITI-----MGEELI 866
            :|  |||:..  ...:|:|:..||.:.| .:..||:||          ..::|:     :|::.:
  Fly   788 ITKEDETAAAPSQAEEKYRVVAPEAMHESFMSDSEEEGGEDNMLSDQPYRYLTVDEMKSLGDDSL 852

Human   867 SF---KAERRDSRDVDEEKELLDFV-PKLDQVVESPAIPRI----PCAMPETVVIRSEEQEQASK 923
            ..   :.||.||..:.:..|....| |.:.:.|.||...::    |.|..:.|.|.:      ..
  Fly   853 PIDVTRDERMDSNRMTQSAEYASGVPPTIGEEVISPHKTQVYGSSPKATVDGVYIAN------GS 911

Human   924 EYDEDSLIPSSPATETSDNISPVASPVHTG-------FLVSFMVDARGGSMRGSRHNGLRVVIPP 981
            .:||                     |.|.|       |||||:||||||:|||.||:|:|::||.
  Fly   912 GHDE---------------------PPHVGRKLSWKSFLVSFLVDARGGAMRGCRHSGVRMIIPS 955

Human   982 RTCAAPTRITCRLVKPQKLSTPPPLAEEEGLASRIIALGPTGAQFLSPVIVEIPHFASHGRGDRE 1046
            |:...|||:|||.||||:...||.|.|.|.||||::.|||...:|:.||::|:|||||....:||
  Fly   956 RSTCQPTRVTCRYVKPQRTMHPPQLMEGEALASRVLELGPCSTKFIGPVVMEVPHFASLRGKERE 1020

Human  1047 LVVLRSENGSVWKEHRSRYGESYLDQILNGM--DEELGSLEELEKKRVCRIITTDFPLYFVIMSR 1109
            :::|||:||..|:||.....|..:..:|...  .||:..|||.....|||.:|.|||.||.::||
  Fly  1021 IIILRSDNGETWREHTIDNSEEIIHDVLQQCFEPEEIAQLEEQAGNHVCRFVTYDFPQYFAVVSR 1085

Human  1110 LCQDYDTIGPEGGSLKSKLVPLVQATFPENAVTKRVKLALQAQPVPDELVTKLLGNQATFSPIVT 1174
            :.|:...||||||.:.|.:||.|||.||:.|:||::|:.||||||..:|..||||.....|||||
  Fly  1086 IRQEVHAIGPEGGMVSSTVVPQVQAVFPQGALTKKIKVGLQAQPVDPDLTAKLLGRGVAVSPIVT 1150

Human  1175 VEPRRRKFHRPIGLRIPLPPSWTDNPRDSGEGDTTSLRLLCSVIGGTDQAQWEDITGTTKLVYAN 1239
            |||||||||:.|.|.:|.|.:.:....:...|:|.:||||||:.||..:|||||:||:|.|.:.|
  Fly  1151 VEPRRRKFHKAITLSMPAPKAHSQGMINQYSGNTPTLRLLCSITGGPSRAQWEDVTGSTPLTFVN 1215

Human  1240 ECANFTTNVSARFWLSDCPRTAEAVNFATLLYKELTAVPYMAKFVIFAKMNDPREGRLRCYCMTD 1304
            :|.:|||.|||||||.||...::|...||.||||:..||::||||:|||..:|.|.:||.:||||
  Fly  1216 DCVSFTTTVSARFWLMDCRNISDATKMATELYKEVIHVPFIAKFVVFAKKVEPFEAKLRVFCMTD 1280

Human  1305 DKVDKTLEQHENFVEVARSRDIEVLEGMSLFAELSGNLVPVKKAAQQRSFHFQSFRENRLAMPVK 1369
            |:.|||||:||.:.|||:|||:|||||...:.|::||||||.|:..|....|::||||||...|:
  Fly  1281 DREDKTLEKHELYTEVAKSRDVEVLEGKPQYIEMAGNLVPVTKSGDQLQVQFKAFRENRLPFTVR 1345

Human  1370 VRDSSREPGGSLSFLR--KAMKYEDTQHILCHLNITMPPCA---KGSGAEDRRRTPTPLALRYSI 1429
            |:|...:..|...|::  |..|.|..|..:|.|||.:|...   ..:...||    ...|.|.|:
  Fly  1346 VKDQHADIVGRTLFMKEPKVAKGEPPQQPICILNIVLPEAVIPDSTTAFSDR----VTSAYRTSM 1406

Human  1430 LSESTPGSLSGTEQ----AEMKMAVISEHLGLSWAELARELQFSVEDINRIRVENPNSLLEQSVA 1490
            .      |||..:.    .::::..:|..||..|.:||.|:..:.|:|:.|..:|.:|:..|:.:
  Fly  1407 F------SLSKHQNDHYIGDIRIVDLSNLLGKDWIQLAPEIGINGEEIDEIINQNTDSIARQAQS 1465

Human  1491 LLNLWVIREGQNANMENLYTALQSIDRGEIVNMLEGSGRQSRNLKPD---------------RRH 1540
            ::.|:  ::..|.::.:|.|||::|.|.:|:...: |||.|.:.:.|               ||.
  Fly  1466 MIRLY--KDKPNYDILSLETALKNIGRDDIMKKCK-SGRLSHSREFDEADLMKNSESVEELVRRE 1527

Human  1541 TDRDYSLSPSQMNGYSSLQDELLSPASLGCALSSPL--RADQYWNEVAVLDAIPLAATEHDTMLE 1603
            :.|...::..:...||:.:.|:....|...|....:  |.::....:::..:||.:..:.:...|
  Fly  1528 SKRIQQINEREEVKYSAEEKEVEESESDEEAAKRTVAERREKIVKRLSIERSIPASTQKKEITRE 1592

Human  1604 MSD-------------------MQVWSAGLTPSLVTAED----------SSLECSKAEDSDATGH 1639
            :::                   ||:.:..:.....|..|          .|.|.||:|......|
  Fly  1593 ITEIKRKSLIEDKKAHHESEILMQLPADNVIIKTTTVPDQVIKMKMGKMDSTEVSKSEFDKELTH 1657

Human  1640 EWKLEGALSEEPRGP-----------ELGSLELVEDDTVD---------SDATNGLIDLLEQEEG 1684
            ::|..|..|||...|           ::.:.|..|.|.|.         .:|.:...|.||.|  
  Fly  1658 KFKTSGRSSEEEDQPSYPDQTDKIVQDISAAEKKEKDGVTFSRVTTITRQEARDITEDFLEIE-- 1720

Human  1685 QRSEEKLPGS---------------KRQDDATGAGQDSENEVSLVSGHQRGQARITHSPTVSQVT 1734
            :||:  ||.:               ::........|::..||..|               :|:||
  Fly  1721 KRSQ--LPATSTTATVHEKFVEEIKEKTSPLASVPQETVKEVQQV---------------ISEVT 1768

Human  1735 ERSQDRLQDWDADGSIVSYLQDAAQGSWQEEVTQGPHSFQGT--STMTEGLEPGGSQEYEKV-LV 1796
            |.:..:::      :|:|..:.:........:...| |.:.|  |...:.||...:...|:| .|
  Fly  1769 EIASKKVE------NIISSFESSKSVDATTVLPTQP-SVESTKVSETIKNLEDAKAVSAEQVKTV 1826

Human  1797 SVSEHTWTEQPEAESSQADRDRRQQGQEEQVQEAKNTFTQVVQGNEFQNIPGEQVTEEQFTDEQG 1861
            .|.|.:..|:..||...........|.|.:.|..|  ||:....:..:.....:.|.|..|:...
  Fly  1827 HVVESSSIEETIAEFEAKKVKYDFHGGEPKTQIPK--FTRKPSDDSMKPTAAPRATVESETESVL 1889

Human  1862 NIVTKKIIRKV-VRQI-----DLSSADA 1883
            ....:|.|.|: |:.|     .:|..||
  Fly  1890 ETKAEKPISKIPVKTIPTEAQKVSEVDA 1917

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ANK1NP_001135918.1 ANKYR 1..228 CDD:440430 123/185 (66%)
ANK repeat 47..75 CDD:293786 19/27 (70%)
ANK repeat 77..108 CDD:293786 17/30 (57%)
ANK repeat 111..141 CDD:293786 19/29 (66%)
ANK repeat 143..174 CDD:293786 22/30 (73%)
ANKYR 154..441 CDD:440430 186/286 (65%)
ANK repeat 176..200 CDD:293786 17/23 (74%)
ANK repeat 209..236 CDD:293786 17/26 (65%)
ANK repeat 239..269 CDD:293786 19/29 (66%)
ANK repeat 271..302 CDD:293786 14/30 (47%)
ANK repeat 304..335 CDD:293786 19/30 (63%)
ANKYR 320..606 CDD:440430 167/285 (59%)
ANK repeat 337..368 CDD:293786 17/30 (57%)
ANK repeat 373..401 CDD:293786 19/27 (70%)
ANK repeat 403..434 CDD:293786 23/30 (77%)
ANK repeat 436..467 CDD:293786 21/30 (70%)
ANK repeat 469..500 CDD:293786 16/30 (53%)
ANK repeat 502..531 CDD:293786 13/28 (46%)
ANK repeat 536..566 CDD:293786 12/29 (41%)
ANKYR 552..820 CDD:440430 150/267 (56%)
ANK repeat 568..599 CDD:293786 18/30 (60%)
ANK repeat 601..629 CDD:293786 16/27 (59%)
ANK repeat 634..665 CDD:293786 19/30 (63%)
ANK repeat 667..698 CDD:293786 16/30 (53%)
ANK repeat 700..731 CDD:293786 16/30 (53%)
ANK repeat 733..764 CDD:293786 19/30 (63%)
ANK repeat 766..794 CDD:293786 17/27 (63%)
ZU5 952..1056 CDD:128514 59/110 (54%)
UPA_2 1277..1406 CDD:375346 65/130 (50%)
Death_ank1 1442..1525 CDD:260067 22/86 (26%)
Ank2NP_001189070.1 ANKYR 10..308 CDD:440430 191/297 (64%)
ANK repeat 10..41 CDD:293786 20/30 (67%)
ANK repeat 43..74 CDD:293786 17/30 (57%)
ANK repeat 76..107 CDD:293786 20/30 (67%)
ANK repeat 109..134 CDD:293786 18/24 (75%)
ANK repeat 175..202 CDD:293786 17/26 (65%)
ANKYR 190..473 CDD:440430 175/282 (62%)
ANK repeat 204..235 CDD:293786 19/30 (63%)
ANK repeat 237..268 CDD:293786 14/30 (47%)
ANK repeat 270..300 CDD:293786 18/29 (62%)
ANK repeat 303..367 CDD:293786 39/63 (62%)
ANK repeat 369..400 CDD:293786 23/30 (77%)
ANKYR 383..671 CDD:440430 159/287 (55%)
ANK repeat 402..433 CDD:293786 21/30 (70%)
ANK repeat 435..466 CDD:293786 16/30 (53%)
ANK repeat 468..497 CDD:293786 13/28 (46%)
ANK repeat 501..530 CDD:293786 12/28 (43%)
ANK repeat 535..565 CDD:293786 17/29 (59%)
ANK repeat 567..598 CDD:293786 18/30 (60%)
PHA03100 599..>773 CDD:476869 97/173 (56%)
ANK repeat 600..630 CDD:293786 18/29 (62%)
ANK repeat 633..662 CDD:293786 15/28 (54%)
ANK repeat 666..697 CDD:293786 16/30 (53%)
ANK repeat 699..730 CDD:293786 19/30 (63%)
ANK repeat 732..762 CDD:293786 18/29 (62%)
ZU5 930..1027 CDD:459941 54/96 (56%)
UPA_2 1253..1384 CDD:375346 65/130 (50%)
Death_ank 1417..1497 CDD:260029 22/81 (27%)
PTZ00121 <1443..2235 CDD:173412 102/506 (20%)
PTZ00449 <3292..3611 CDD:185628
PTZ00449 <4400..4857 CDD:185628
PTZ00449 <4908..5267 CDD:185628
PTZ00108 <5179..5374 CDD:240271
PTZ00108 <6034..6230 CDD:240271
PTZ00449 <6620..6979 CDD:185628
PTZ00108 <7119..7314 CDD:240271
PTZ00108 <7347..7544 CDD:240271
PTZ00108 <7651..7848 CDD:240271
PTZ00449 <7804..8119 CDD:185628
PTZ00108 <8183..8381 CDD:240271
PTZ00449 <8430..8745 CDD:185628
PTZ00449 <8784..9125 CDD:185628
PTZ00449 <9028..9353 CDD:185628
PHA03307 9225..>9575 CDD:223039
PHA03307 9903..>10259 CDD:223039
PTZ00108 <10177..10451 CDD:240271
Blue background indicates that the domain is not in the aligned region.

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