DRSC/TRiP Functional Genomics Resources

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Protein Alignment ANK1 and res2

DIOPT Version :9

Sequence 1:XP_011542792.1 Gene:ANK1 / 286 HGNCID:492 Length:1969 Species:Homo sapiens
Sequence 2:NP_593032.1 Gene:res2 / 2541871 PomBaseID:SPAC22F3.09c Length:657 Species:Schizosaccharomyces pombe


Alignment Length:345 Identity:89/345 - (25%)
Similarity:130/345 - (37%) Gaps:62/345 - (17%)


- Green bases have known domain annotations that are detailed below.


Human   425 KGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGH-----LPI 484
            |..||:.|...|..|..::....| .|.|  .:..:||....||.:..:::......     ||.
pombe   121 KQKKPSVRGRRGRKPSSLSSSTLH-SVNE--KQPNSSISPTIESSMNKVNLPGAEEQVSATPLPA 182

Human   485 VKNLLQRGASPNVSNVK-------VETPL----------HMAARAGHTEVAKYLLQNKAKVNAKA 532
            ..|.|   .|||.:.:|       :|.||          .:....|......|......:||:..
pombe   183 SPNAL---LSPNDNTIKPVEELGMLEAPLDKYEESLLDFFLHPEEGRIPSFLYSPPPDFQVNSVI 244

Human   533 KDD-QTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLH---IAAREGHVET---VLALLEK 590
            .|| .|.||.|..:||..|:||||..||:..:......|||.   |.......:|   ||.||:.
pombe   245 DDDGHTSLHWACSMGHIEMIKLLLRANADIGVCNRLSQTPLMRSVIFTNNYDCQTFGQVLELLQS 309

Human   591 EA------SQAC---MTKKGFTPLHV-AAKYGKVRVAELLLERDAHPNAA------GKNGLTPLH 639
            ..      .|:.   :.:...||..| ||||....:.|.|:......|..      ..||.|.|.
pombe   310 TIYAVDTNGQSIFHHIVQSTSTPSKVAAAKYYLDCILEKLISIQPFENVVRLVNLQDSNGDTSLL 374

Human   640 VAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVAR---SLLQYGGSA--NAESVQ 699
            :|..:..:|.|..||....:|..|.....|     |.:..:|..:   ||||...:|  :|.|..
pombe   375 IAARNGAMDCVNSLLSYNANPSIPNRQRRT-----ASEYLLEADKKPHSLLQSNSNASHSAFSFS 434

Human   700 GVTPLHLAAQ-EGHAEMVAL 718
            |::|..::.. ..||.:.|:
pombe   435 GISPAIISPSCSSHAFVKAI 454

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ANK1XP_011542792.1 ANK 47..163 CDD:238125
ANK repeat 47..75 CDD:293786
ANK 108..229 CDD:238125
ANK repeat 109..140 CDD:293786
Ank_2 114..204 CDD:289560
ANK repeat 143..173 CDD:293786
ANK 170..324 CDD:238125
ANK repeat 175..206 CDD:293786
ANK repeat 208..232 CDD:293786
ANK repeat 241..268 CDD:293786
Ank_2 242..333 CDD:289560
ANK 265..390 CDD:238125
ANK repeat 271..301 CDD:293786
ANK repeat 303..334 CDD:293786
Ank_2 308..397 CDD:289560
ANK repeat 336..367 CDD:293786
ANK repeat 369..400 CDD:293786
Ank 402..432 CDD:278452 3/6 (50%)
ANK repeat 405..433 CDD:293786 3/7 (43%)
ANKYR 406..619 CDD:223738 60/232 (26%)
ANK 430..555 CDD:238125 36/147 (24%)
ANK repeat 435..466 CDD:293786 7/30 (23%)
ANK repeat 468..499 CDD:293786 8/35 (23%)
ANK repeat 501..532 CDD:293786 8/47 (17%)
ANK 529..654 CDD:238125 43/147 (29%)
ANK repeat 534..563 CDD:293786 15/29 (52%)
ANK repeat 568..598 CDD:293786 10/44 (23%)
ANK repeat 600..631 CDD:293786 10/37 (27%)
Ank_2 605..696 CDD:289560 27/102 (26%)
ANK repeat 633..661 CDD:293786 9/27 (33%)
ANK repeat 666..697 CDD:293786 9/35 (26%)
ANK 666..695 CDD:197603 8/33 (24%)
ANK 694..819 CDD:238125 7/26 (27%)
ANK repeat 699..730 CDD:293786 5/21 (24%)
Ank_2 704..795 CDD:289560 3/16 (19%)
ANK repeat 732..763 CDD:293786
ANK repeat 765..796 CDD:293786
Ank_5 785..839 CDD:290568
ANK repeat 798..826 CDD:293786
ZU5 984..1088 CDD:128514
Death_ank1 1474..1557 CDD:260067
res2NP_593032.1 KilA-N 28..104 CDD:282266
ANK 244..389 CDD:238125 42/144 (29%)
ANK repeat 247..278 CDD:293786 14/30 (47%)
Ank_2 252..399 CDD:289560 42/146 (29%)
ANK repeat 280..366 CDD:293786 20/85 (24%)
ANK 363..>433 CDD:238125 20/74 (27%)
ANK repeat 368..399 CDD:293786 10/30 (33%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4177
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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