DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ANK1 and res1

DIOPT Version :9

Sequence 1:	XP_011542792.1	Gene:	ANK1 / 286	HGNCID:	492	Length:	1969	Species:	Homo sapiens
Sequence 2:	NP_595496.1	Gene:	res1 / 2541153	PomBaseID:	SPBC725.16	Length:	637	Species:	Schizosaccharomyces pombe

Alignment Length:	465	Identity:	104/465 - (22%)
Similarity:	159/465 - (34%)	Gaps:	121/465 - (26%)

- Green bases have known domain annotations that are detailed below.

Human   275 LHIAAHYENLNVAQLLLNRGASV-----NFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKT 334
            :.:|..|...::.|.|:....|.     .||||:...|.. |.||.:.:               .
pombe    85 VELAHEYNVFDLIQPLIEYSGSAFMPMSTFTPQSNRKPTE-AYRRNSPV---------------K 133

Human   335 KDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYD-AEIDD 398
            |....|.|           .:|..:.:.....:.:.:|.||.|          |.||.| ....|
pombe   134 KSFSRPSH-----------SLLYPYTSSNNMTSTSRMSGIHDA----------LSLQSDFTRSPD 177

Human   399 ITLDHLT-PLH--VAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGA 460
            :..|..| .||  .|:....:..|:.|||....||:.....|.         :.|..:..:..|
pombe   178 MPSDSFTGSLHDIKASPFSSNNYAQSLLDYFLLPNTTQPPDFV---------YDRPSDWDVNAG- 232

Human   461 SIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPL------HMAARAGHTEVAK 519
                :.|.|.|.||.|:.||:|.::..|||.||:....|...:|.|      .|.......||..
pombe   233 ----IDEDGHTALHWAAAMGNLEMMHALLQAGANVVAVNYLQQTSLMRCVMFTMNYDLQTFEVVS 293

Human   520 YLLQNKAKVNAKAKDDQTPLHCAARIGHTN--------MVKLLLENNANP----------NLATT 566
            .|||:...:|...  .||..|..|.:..:.        .:.:||:|....          ||...
pombe   294 ELLQSAICMNDSF--GQTVFHHIALLASSKSKMEAARYYMDILLQNLTATQSVDVAAQIINLQDD 356

Human   567 AGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERD-AHPNAA 630
            .|.|.|.|.||.|..:....||...||.:....:|..|            .:.|..:| :.|
pombe   357 HGDTALLICARNGAKKCARLLLSFYASSSIPNNQGQYP------------TDFLSSKDMSFP--- 406

Human   631 GKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAW----------------NGYTPLHIAAKQNQ 679
             :|..:||:..:..|.:|.:|  .|:....|..:.                |.:|.|...:|.::
pombe   407 -ENDDSPLNSKIEDNLIDNLK--YPQSLDDHLSSKKPISYFSNKLTHQTLPNVFTQLSELSKCHE 468

Human   680 VEVARSLLQY 689
            ..:|...|.|
pombe   469 ASLAEKQLTY 478

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ANK1	XP_011542792.1	ANK	47..163	CDD:238125
		ANK repeat	47..75	CDD:293786
		ANK	108..229	CDD:238125
		ANK repeat	109..140	CDD:293786
		Ank_2	114..204	CDD:289560
		ANK repeat	143..173	CDD:293786
		ANK	170..324	CDD:238125	13/53 (25%)
		ANK repeat	175..206	CDD:293786
		ANK repeat	208..232	CDD:293786
		ANK repeat	241..268	CDD:293786
		Ank_2	242..333	CDD:289560	13/62 (21%)
		ANK	265..390	CDD:238125	22/119 (18%)
		ANK repeat	271..301	CDD:293786	6/30 (20%)
		ANK repeat	303..334	CDD:293786	4/30 (13%)
		Ank_2	308..397	CDD:289560	15/89 (17%)
		ANK repeat	336..367	CDD:293786	3/30 (10%)
		ANK repeat	369..400	CDD:293786	9/31 (29%)
		Ank	402..432	CDD:278452	11/32 (34%)
		ANK repeat	405..433	CDD:293786	10/30 (33%)
		ANKYR	406..619	CDD:223738	58/238 (24%)
		ANK	430..555	CDD:238125	32/138 (23%)
		ANK repeat	435..466	CDD:293786	3/30 (10%)
		ANK repeat	468..499	CDD:293786	13/30 (43%)
		ANK repeat	501..532	CDD:293786	9/36 (25%)
		ANK	529..654	CDD:238125	32/143 (22%)
		ANK repeat	534..563	CDD:293786	7/46 (15%)
		ANK repeat	568..598	CDD:293786	11/29 (38%)
		ANK repeat	600..631	CDD:293786	5/31 (16%)
		Ank_2	605..696	CDD:289560	18/102 (18%)
		ANK repeat	633..661	CDD:293786	7/27 (26%)
		ANK repeat	666..697	CDD:293786	7/24 (29%)
		ANK	666..695	CDD:197603	7/24 (29%)
		ANK	694..819	CDD:238125
		ANK repeat	699..730	CDD:293786
		Ank_2	704..795	CDD:289560
		ANK repeat	732..763	CDD:293786
		ANK repeat	765..796	CDD:293786
		Ank_5	785..839	CDD:290568
		ANK repeat	798..826	CDD:293786
		ZU5	984..1088	CDD:128514
		Death_ank1	1474..1557	CDD:260067
res1	NP_595496.1	KilA-N	26..102	CDD:282266	4/16 (25%)
		ANKYR	125..280	CDD:223738	47/204 (23%)
		ANK	233..378	CDD:238125	40/146 (27%)
		ANK repeat	236..304	CDD:293786	22/67 (33%)
		Ank_2	241..329	CDD:289560	25/89 (28%)
		ANK repeat	306..355	CDD:293786	9/50 (18%)
		Ank_2	<351..>394	CDD:289560	14/42 (33%)
		ANK repeat	357..388	CDD:293786	11/30 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4177
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900