DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ANK1 and unc-44

DIOPT Version :9

Sequence 1:XP_011542792.1 Gene:ANK1 / 286 HGNCID:492 Length:1969 Species:Homo sapiens
Sequence 2:NP_001367345.1 Gene:unc-44 / 177366 WormBaseID:WBGene00006780 Length:6994 Species:Caenorhabditis elegans


Alignment Length:2049 Identity:871/2049 - (42%)
Similarity:1189/2049 - (58%) Gaps:306/2049 - (14%)


- Green bases have known domain annotations that are detailed below.


Human    17 QALQEQKEKEESNRKRRNRSRDRKKKADAATSFLRAARSGNLDKALDHLRNGVDINTCNQGPSAS 81
            |..|:|.|.:|....    :.....:|:.:.|||||||:|:|:|.|:.||.|.||||.|      
 Worm     9 QPQQQQPESQEVQAP----AAPEPGRAEGSASFLRAARAGDLEKVLELLRAGTDINTSN------ 63

Human    82 AVDLLLRCRISQSTGLLRVLYNQNRKKNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTA 146
                                      .||||.|||||||||.::|.||:.::..::..|:|||||
 Worm    64 --------------------------ANGLNSLHLASKEGHSEVVRELIKRQAQVDAATRKGNTA 102

Human   147 LHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFT 211
            ||||:||||..:|..||..|||||.||..|||||||||||||.||||:||::||||.::||||||
 Worm   103 LHIASLAGQSLIVTILVENGANVNVQSVNGFTPLYMAAQENHEEVVKYLLKHGANQALSTEDGFT 167

Human   212 PLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLH 276
            ||||||||||:.|||.|:...:|||||||||||||:.|||..|.:||||:.||||.||:||||||
 Worm   168 PLAVALQQGHDRVVAVLLENDSKGKVRLPALHIAAKKDDTTAATLLLQNEHNPDVTSKSGFTPLH 232

Human   277 IAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPL 341
            |||||.:.||.||||.:||:||:..::.|:|||:|::.|...|..|||.|||.|:::|||.||||
 Worm   233 IAAHYGHENVGQLLLEKGANVNYQARHNISPLHVATKWGRTNMANLLLSRGAIIDSRTKDLLTPL 297

Human   342 HCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTP 406
            |||||:||.::.::|:..||||.|||||||:|:||||||||:|..|.||.:.|.:||:|:|:|||
 Worm   298 HCAARSGHDQVVDLLVVQGAPISAKTKNGLAPLHMAAQGDHVDAARTLLYHRAPVDDVTVDYLTP 362

Human   407 LHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLT 471
            |||||||||.||||:|||:.|.|||||||||||||||||||.::|:|||||..|:|:|.||||||
 Worm   363 LHVAAHCGHVRVAKLLLDRSADPNSRALNGFTPLHIACKKNRIKVVELLLKYRAAIEATTESGLT 427

Human   472 PLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQ 536
            |||||:|||.:.||..|||:||:|:|..|:.|||||:||||..|:|.:.|::|.|||:|:|::.|
 Worm   428 PLHVAAFMGAINIVIYLLQQGANPDVETVRGETPLHLAARANQTDVVRVLIRNGAKVDAQARELQ 492

Human   537 TPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKG 601
            ||||.|:|:|:|::|.|||:..||.|..|...::||||||:||..|....||:..|.:..:||||
 Worm   493 TPLHIASRLGNTDIVILLLQAGANSNATTRDNYSPLHIAAKEGQEEVAGILLDHNADKTLLTKKG 557

Human   602 FTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWN 666
            |||||:|:|||.:.|..|||||....:..|||.:||||||.|:||..:..|||..|.|..:.|.|
 Worm   558 FTPLHLASKYGNLEVVRLLLERGTPVDIEGKNQVTPLHVAAHYNNDKVAMLLLENGASAKAAAKN 622

Human   667 GYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNK 731
            ||||||||||:||:|:|.:|||:....||:|..|.|||||:|||||.|:..||:...::......
 Worm   623 GYTPLHIAAKKNQMEIASTLLQFKADPNAKSRAGFTPLHLSAQEGHKEISGLLIENGSDVGAKAN 687

Human   732 SGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKT 796
            :|||.:||.|||.|||||.:|..:|..:::.|..||||||||.|:|.:.:||||:::.|||..||
 Worm   688 NGLTAMHLCAQEDHVPVAQILYNNGAEINSKTNAGYTPLHVACHFGQLNMVKFLVENGADVGEKT 752

Human   797 KLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDE---T 858
            :..|:||||||||||.:.|..||:|||||||.::.|.|||:||:||||:||.:.|:.||:.   |
 Worm   753 RASYTPLHQAAQQGHNNCVRYLLENGASPNEQTATGQTPLSIAQRLGYVSVVETLRTVTETTVIT 817

Human   859 SFVLVSDKHRMSFPETVDE-ILDVSEDEGTA---------------------------HITIMGE 895
            ....|.::::...||.::| :...|||||.|                           |:...||
 Worm   818 ETTTVDERYKPQNPEAMNETMFSESEDEGQAAEHEAVAAHEKDFSDNLTQGLQDSTGVHMIHTGE 882

Human   896 ELISFKAE--------RRDSRDVDEEKELLDFVPKLDQVVESPAI-----------PR------- 934
            :|:....|        :.:|..:..|||.....|    |..|..|           ||       
 Worm   883 QLLQRSQELENGGAIPKINSGGMSPEKEFAKIAP----VATSSPIATSNSQSFGIAPRAGSISGQ 943

Human   935 -----IPCAMP----ETVVIRSEEQEQASKEYDED--SLIPSSPATETSDNISPVASPV------ 982
                 :..|.|    |.:|.|::.....:..||..  :::.:..|    ||: |:...|      
 Worm   944 FQQQPLHGAGPEDNLEELVRRAQNHPINAGNYDNGGVAMLENGHA----DNV-PIGHHVTQPSKL 1003

Human   983 -HTGFLVSFMVDARGGSMRGSRHNGLRVVIPPRTCAAPTRITCRLVKPQKLSTPPPLAEEEGLAS 1046
             |..||:||:||||||:|||.||:|:|:::|||..:.|.|:|||.::..||:.||||:|.|.|||
 Worm  1004 QHRTFLISFLVDARGGAMRGCRHSGVRIIVPPRKASQPIRVTCRYLRKDKLAHPPPLSEGEELAS 1068

Human  1047 RIIALGPTGAQFLSPVIVEIPHFASHGRGDRELVVLRSENGSVWKEHRSRYGESYLDQILN-GMD 1110
            ||:.:.|.||:||.|||:|:|||||....:||:|:|||::|..||||:....|..:.::|| ..|
 Worm  1069 RILEMAPAGAKFLGPVILEVPHFASLRDREREIVILRSDDGQHWKEHQLEATEDAVQEVLNESFD 1133

Human  1111 -EELGSLEELEKKRVCRIITTDFPLYFVIMSRLCQDYDTIGPEGGSLKSKLVPLVQATFPENAVT 1174
             |:|..|::|:..|:.||:|:|||:||.:::|:.|:...:|||||.:.|.:||.|||.||:.::|
 Worm  1134 AEDLAQLDDLQTPRITRILTSDFPMYFAVVTRVRQEVHCVGPEGGVIISSVVPRVQAIFPDGSLT 1198

Human  1175 KRVKLALQAQPVPDELVTKLLGNQATFSPIVTVEPRRRKFHRPIGLRIPLPPSWTDNPRD----- 1234
            |.:|:::||||||.|:||:|.||:...||||||||||||||:||.|.||||.|   |.|.     
 Worm  1199 KTIKVSVQAQPVPQEMVTRLHGNRVAVSPIVTVEPRRRKFHKPITLCIPLPQS---NNRGMLTQY 1260

Human  1235 SGE--GDTTSLRLLCSVIGGTDQAQWEDITGTTKLVYANECANFTTNVSARFWLSDCPRTAEAVN 1297
            ||:  .:..:||||||:.||:..||||||||||:|.:..:..:|||.|||||||.||....:|..
 Worm  1261 SGQQGQEPPTLRLLCSITGGSAPAQWEDITGTTQLTFTGDEVSFTTTVSARFWLMDCQTPRDAAR 1325

Human  1298 FATLLYKELTAVPYMAKFVIFAKMNDPREGRLRCYCMTDDKVDKTLEQHENFVEVARSRDIEVLE 1362
            .|..:|.|..::||||||.:||:...|.||:||.:||||||.|||||:.|:|..:|:|||:|||:
 Worm  1326 MAQEVYNEAISIPYMAKFAVFARRTFPVEGQLRVFCMTDDKEDKTLEKQEHFKLIAKSRDVEVLK 1390

Human  1363 GMSLFAELSGNLVPVKKAAQQRSFHFQSFRENRLAMPVKVR---DSSREPGGSLSFLRKAMKYED 1424
            |...|.|.||||||:.|:..|.|..|..|:|||||..||.|   |:.....|.:.|:.:.....|
 Worm  1391 GKHQFLEFSGNLVPITKSGDQLSLFFLPFQENRLAFMVKTRSNDDNEAATEGRIGFMAEPKIRSD 1455

Human  1425 T---QHILCHLNITMPP-CAKGSGAEDRRRTPTPLALRY-SILSESTPGSLSGTEQAEMKMAVIS 1484
            .   |..:|.|.|::|. ..:...|...::..||...|| |.|.:..|         |.....:.
 Worm  1456 ALPPQQPICTLAISLPEYTGEIKTAPPPKKDLTPFEQRYGSALEKDLP---------EFVHQNVL 1511

Human  1485 EHLGLSWAELARELQFSVEDINRIRVENPNSLLEQSVALLNLWVIREGQNANMENLYTALQSIDR 1549
            :.:|..|..|.|.|:....||..||...|.   ::....|.:|:..:.::||.:||..||:.|.|
 Worm  1512 KGIGADWPRLGRALEVPHRDIQHIRQNYPG---QECKNTLKIWIHLKKEDANQDNLDQALRQIGR 1573

Human  1550 GEIVNMLEGSGRQSRNLKPDR--RHTDRDYSLSPSQMNGYSSLQDELLSPASLGCALSSPLR--- 1609
            .:||..:...       :||.  .::..|   ||||..                    .|:|   
 Worm  1574 DDIVRSIAYG-------EPDALINYSQAD---SPSQKR--------------------EPIRHFE 1608

Human  1610 ----ADQYWNEVAVLDAI---PLAATEHDTMLEMSDMQV----WSAGLTPSLVTAE-DSSLECSK 1662
                |.....||...|.:   |:..|.|   :|.:...|    :||.:..|.|..| :...|...
 Worm  1609 EVPAATLVKREVRTEDLVTREPVQPTHH---VEQATTVVQEPSYSAPVHHSPVPEEPEMEEEAPV 1670

Human  1663 AEDSDATGHEWKLEGALSEEPRGPELGSLELVEDDTV-----DSDATN-GLIDL---LEQEEGQR 1718
            ||.....    :.|..:.:...||      :||:.|:     |..|.| .::|.   |.::|.|:
 Worm  1671 AEMRTVV----RTERHVHDSEDGP------VVEERTITTTYEDDVAVNENIVDRTVPLNEDEQQK 1725

Human  1719 SEEKLPGSKRQDDATGAGQDSENEVSLVSGHQRGQARITHSPTVSQVTERSQDRQLFQAPTPRSS 1783
            .||.   ::..|:            |..|..||  :.|....|..||.|..:  |..::.:.|  
 Worm  1726 WEEL---NRLADE------------SSPSPAQR--STIVAESTSEQVPEDVE--QSVESESHR-- 1769

Human  1784 GLVRLQDWDADGSIVSYLQDAAQGSWQEEVTQGPHSFQGTSTMTEGLEPGGSQEYEKVLVSVSEH 1848
                    :.||:||:           ..||        ||.::|  .|.||.....  |...||
 Worm  1770 --------EDDGTIVT-----------TTVT--------TSHISE--SPSGSPTRRS--VEPEEH 1803

Human  1849 TWTEQPEAESSQADRDRRQQGQEEQVQEAKNTFTQVVQGNEFQNIPGEQVTEEQFTDEQGNIVTK 1913
            ..::..:.|:|.|:   :..||:....:.|.|                  .||.||:|.|::|..
 Worm  1804 RHSQHEDHEASGAE---QHSGQDSGTTQKKET------------------AEEGFTNEDGSVVVS 1847

Human  1914 KIIRKVVRQIDLSSADAAQEHEEVTVEGPLEDPS 1947
            |.:.:||..            ...|:.|..|:||
 Worm  1848 KKMTRVVTT------------TRTTLPGEGEEPS 1869

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ANK1XP_011542792.1 ANK 47..163 CDD:238125 50/115 (43%)
ANK repeat 47..75 CDD:293786 18/27 (67%)
ANK 108..229 CDD:238125 82/120 (68%)
ANK repeat 109..140 CDD:293786 16/30 (53%)
Ank_2 114..204 CDD:289560 59/89 (66%)
ANK repeat 143..173 CDD:293786 20/29 (69%)
ANK 170..324 CDD:238125 102/153 (67%)
ANK repeat 175..206 CDD:293786 23/30 (77%)
ANK repeat 208..232 CDD:293786 18/23 (78%)
ANK repeat 241..268 CDD:293786 18/26 (69%)
Ank_2 242..333 CDD:289560 54/90 (60%)
ANK 265..390 CDD:238125 76/124 (61%)
ANK repeat 271..301 CDD:293786 21/29 (72%)
ANK repeat 303..334 CDD:293786 14/30 (47%)
Ank_2 308..397 CDD:289560 52/88 (59%)
ANK repeat 336..367 CDD:293786 18/30 (60%)
ANK repeat 369..400 CDD:293786 19/30 (63%)
Ank 402..432 CDD:278452 23/29 (79%)
ANK repeat 405..433 CDD:293786 22/27 (81%)
ANKYR 406..619 CDD:223738 131/212 (62%)
ANK 430..555 CDD:238125 80/124 (65%)
ANK repeat 435..466 CDD:293786 22/30 (73%)
ANK repeat 468..499 CDD:293786 21/30 (70%)
ANK repeat 501..532 CDD:293786 17/30 (57%)
ANK 529..654 CDD:238125 63/124 (51%)
ANK repeat 534..563 CDD:293786 15/28 (54%)
ANK repeat 568..598 CDD:293786 12/29 (41%)
ANK repeat 600..631 CDD:293786 17/30 (57%)
Ank_2 605..696 CDD:289560 49/90 (54%)
ANK repeat 633..661 CDD:293786 15/27 (56%)
ANK repeat 666..697 CDD:293786 20/30 (67%)
ANK 666..695 CDD:197603 18/28 (64%)
ANK 694..819 CDD:238125 64/124 (52%)
ANK repeat 699..730 CDD:293786 14/30 (47%)
Ank_2 704..795 CDD:289560 44/90 (49%)
ANK repeat 732..763 CDD:293786 15/30 (50%)
ANK repeat 765..796 CDD:293786 17/30 (57%)
Ank_5 785..839 CDD:290568 31/53 (58%)
ANK repeat 798..826 CDD:293786 18/27 (67%)
ZU5 984..1088 CDD:128514 58/103 (56%)
Death_ank1 1474..1557 CDD:260067 23/82 (28%)
unc-44NP_001367345.1 ANK repeat 32..63 CDD:293786 18/30 (60%)
PHA03095 37..>387 CDD:222980 228/381 (60%)
ANK repeat 65..96 CDD:293786 16/30 (53%)
ANK repeat 98..129 CDD:293786 21/30 (70%)
ANK repeat 131..156 CDD:293786 19/24 (79%)
ANK repeat 197..224 CDD:293786 18/26 (69%)
ANK repeat 226..257 CDD:293786 21/30 (70%)
PHA02876 <242..>648 CDD:165207 241/405 (60%)
ANK repeat 259..290 CDD:293786 14/30 (47%)
ANK repeat 292..322 CDD:293786 17/29 (59%)
ANK repeat 325..356 CDD:293786 19/30 (63%)
ANK repeat 358..389 CDD:293786 24/30 (80%)
ANK repeat 391..422 CDD:293786 22/30 (73%)
ANK repeat 424..455 CDD:293786 21/30 (70%)
ANK repeat 457..488 CDD:293786 17/30 (57%)
ANK repeat 490..519 CDD:293786 15/28 (54%)
ANK repeat 523..552 CDD:293786 12/28 (43%)
Ank_2 555..>780 CDD:423045 122/224 (54%)
ANK repeat 556..586 CDD:293786 17/29 (59%)
ANK repeat 589..620 CDD:293786 15/30 (50%)
ANK repeat 622..652 CDD:293786 19/29 (66%)
ANK repeat 655..685 CDD:293786 14/29 (48%)
ANK repeat 688..719 CDD:293786 15/30 (50%)
ANK repeat 721..752 CDD:293786 17/30 (57%)
ANK repeat 754..784 CDD:293786 20/29 (69%)
Ank_4 756..807 CDD:372654 33/50 (66%)
ZU5 1008..1110 CDD:128514 58/101 (57%)
UPA_2 1337..1472 CDD:375346 63/134 (47%)
Death_ank 1503..1580 CDD:260029 24/88 (27%)
PTZ00449 <1770..2112 CDD:185628 37/156 (24%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C161469751
Domainoid 1 1.000 253 1.000 Domainoid score I1256
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1011028at2759
OrthoFinder 1 1.000 - - FOG0000917
OrthoInspector 1 1.000 - - otm15488
orthoMCL 1 0.900 - - OOG6_100012
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2336
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
87.780

Return to query results.
Submit another query.