Protein Alignment PNPLA1 and pnpla3

DIOPT Version :10

• Sequence 1: NP_001361552.1
• Gene: PNPLA1 / 285848
• HGNCID: 21246
• Length: 572
• Species: Homo sapiens
• Sequence 2: NP_001002338.2
• Gene: pnpla3 / 436610
• ZFINID: ZDB-GENE-040718-27
• Length: 473
• Species: Danio rerio
• Alignment Length: 520
• Identity: 157/520 - (30%)
• Similarity: 245/520 - (47%)
• Gaps: 104/520 - (20%)

Human    15 SISFSGSGFLSFYQAGAVDALRDLAPRMLETAHRFAGTSAGAVIAALAICGIEMDEYLR-VLNVG 78
            ::||:|.|||..|..|....|.:.||.::..|.:..|.||||:.|::......:::... |:||
Zfish     9 NLSFAGCGFLGIYHIGVASCLLEQAPYLIRGATKIYGASAGALTASVLTTEACIEKCCEDVINV- 72

Human    79 VAEVKKSFLGPLSPSCKMVQMMRQFLYRVLPEDSYKVTTGKLHVSLTRLTDGENVVVSEFTSKEE 143
            ..|.:|..||||.|:..:|:::|..|||.||.:::.:::|:|.|||||:.||:||:||:|:||||
Zfish    73 AKEARKRNLGPLHPTFNIVKVIRGGLYRDLPSNAHTLSSGRLCVSLTRVMDGQNVLVSDFSSKEE 137

Human   144 LIEALYCSCFVPVYCGLIPPTYRGVRYIDGGFTGMQPCAFWTDAITISTFSGQQDICPRDCPAIF 208
            ||:||.||||:|||||||||.:|||||:|||.:...|.:...:.||:|.|||:.||||:|....|
Zfish   138 LIQALICSCFIPVYCGLIPPAFRGVRYVDGGISDNLPQSELKNTITVSPFSGESDICPKDNSTSF 202

Human   209 HDFRMFNCSFQFSLENIARMTHALFPPDLVILHDYYYRGYEDAVLYLRRLNAVYLNSSSKRVIFP 273
            |:.|..|.|.||:|:|..|::.|||||:..:|.:....||:||:.:|:..|.
Zfish   203 HELRFTNTSIQFNLDNAYRLSKALFPPEPKVLAEMCQSGYKDALRFLQENNL------------- 254

Human   274 RVEVYCQ-IELALGNE-----CPERSQPSLRARQASLEGATQPHKEWVPKGDG--RGSHGPPVSQ 330
             ::..|. :::||...     ||.:..|.:.          :..||||.:...  |..|.....|
Zfish   255 -LQAACPGVDMALIQATPTCCCPGKKNPVVE----------ETTKEWVLRRLRLLRKHHWWLDEQ 308

Human   331 PVQTLEFTCESPVSAPVSPLEQPPAQPLASSTPL--SLSGMPPVSFPAVHKPPSSTPGSS----- 388
            .|..|.           :|:::...........|  .::|:.||...:....|.:.|..|
Zfish   309 IVDNLP-----------TPIKKVFCDACREKHGLLAQVTGLLPVRVASYMLLPYTLPVESAYSAA 362

Human   389 ------LPTPPPGLSPLSP------------QQQVQPSGSPARSLHSQAPTSPRPSLGPSTVGAP 435
                  :|..|..:..|:.            ......||:|.|...|:.|.:
Zfish   363 QRFWEWIPEVPADVRWLTEVAGGVYRLAWKGAASEANSGAPLRRCVSEPPMA------------- 414

Human   436 QTLPRSSLSAFPAQPPVEELGQEQPQAVALLVSSK---PKSAVPLVHVKETVSKPYVTESPAEDS 497
                       ..|.|:::.....|.:.:.|.|.|   |.:    :|...::..|   |||..:|
Zfish   415 -----------DLQMPIKDCTGHIPHSASTLDSYKWTFPNN----IHTTSSIDCP---ESPVSES 461

Human   498  497
            Zfish   462  461

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PNPLA1	NP_001361552.1	Pat_PNPLA1	2..388	CDD:132858	134/383 (35%)
		GXSXG. /evidence=ECO:0000255|PROSITE-ProRule:PRU01161	51..55		2/3 (67%)
		DGA/G. /evidence=ECO:0000255|PROSITE-ProRule:PRU01161	172..174		1/1 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	290..457		30/193 (16%)
		Atrophin-1	<295..>493	CDD:460830	37/227 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	489..532		4/9 (44%)
pnpla3	NP_001002338.2	None