Protein Alignment PNPLA1 and Pnpla1

DIOPT Version :10

• Sequence 1: NP_001361552.1
• Gene: PNPLA1 / 285848
• HGNCID: 21246
• Length: 572
• Species: Homo sapiens
• Sequence 2: NP_001030057.1
• Gene: Pnpla1 / 433091
• MGIID: 3617850
• Length: 599
• Species: Mus musculus
• Alignment Length: 614
• Identity: 374/614 - (60%)
• Similarity: 427/614 - (69%)
• Gaps: 79/614 - (12%)

Human     1 MEEQVFKGDPDTPHSISFSGSGFLSFYQAGAVDALRDLAPRMLETAHRFAGTSAGAVIAALAICG 65
            |:|||||||||||||||||||||||:|||||||||||||||||:|||||||||||||||||.:||
Mouse     1 MDEQVFKGDPDTPHSISFSGSGFLSYYQAGAVDALRDLAPRMLDTAHRFAGTSAGAVIAALVVCG 65

Human    66 IEMDEYLRVLNVGVAEVKKSFLGPLSPSCKMVQMMRQFLYRVLPEDSYKVTTGKLHVSLTRLTDG 130
            |||::||||||:|:|||||.||||||||||||||||||||.||||||||..||||||||||:|||
Mouse    66 IEMEKYLRVLNMGLAEVKKFFLGPLSPSCKMVQMMRQFLYDVLPEDSYKFATGKLHVSLTRVTDG 130

Human   131 ENVVVSEFTSKEELIEALYCSCFVPVYCGLIPPTYRGVRYIDGGFTGMQPCAFWTDAITISTFSG 195
            |||||||:.||||||||||||||||||||.|||||||.||||||||.||||:||||:|||||||.
Mouse   131 ENVVVSEYRSKEELIEALYCSCFVPVYCGFIPPTYRGERYIDGGFTSMQPCSFWTDSITISTFSS 195

Human   196 QQDICPRDCPAIFHDFRMFNCSFQFSLENIARMTHALFPPDLVILHDYYYRGYEDAVLYLRRLNA 260
            ||||||||||.|||||||||.|||||||||.||||||||||||||.:||||||.|||.|||||||
Mouse   196 QQDICPRDCPTIFHDFRMFNFSFQFSLENITRMTHALFPPDLVILQEYYYRGYNDAVSYLRRLNA 260

Human   261 VYLNSSSKRVIFPRVEVYCQIELALGNECPERSQPSLRARQASLEGATQPHKEWVPKGDGRGSH- 324
            .||:|.||||||||||||||||:|||:|.|..|..:|.|.:.|...::|.|.:..||.|.:.||
Mouse   261 AYLDSPSKRVIFPRVEVYCQIEVALGHEPPPPSLQNLPALRRSPADSSQTHAQGSPKKDRKDSHS 325

Human   325 --GPPVSQPVQTLEFTCESPVSAPVSPLEQP------PAQP------------------------ 357
              .|.|..|....:.:.|||||..||..:||      ||||
Mouse   326 SAAPSVQTPESGCKESVESPVSLRVSISKQPSVSPLSPAQPVPVMRPTGPRDSCPINVQTPNPER 390

Human   358 -----------------LASST-PLSLSGMPPVSFPAVHKPPSSTPGSSLPTPPPGLSPLSPQQQ 404
                             |||:| ..|.:.:|||..||.....|.| |||:|..    ||.||:..
Mouse   391 GVKGALDSATERGMKDALASATDEQSTTTLPPVLLPAADSRGSKT-GSSVPIG----SPESPRLL 450

Human   405 VQPSGSPARSLHSQAPTSPRPSLGPSTVGAPQTLPRSSLSAFPAQPPVEELGQEQPQAV-ALLVS 468
            ::         .||..|:.|.:||         ||..|.|..||.||||:||.|:|.|. :..:|
Mouse   451 LR---------SSQGATASRATLG---------LPPLSPSTPPAGPPVEDLGPERPTATGSPALS 497

Human   469 SKPKSAVPLVHVKETVSKPYVTESPAEDSNWVNKVFKKNKQKTSGTRKGFPRHSGSKKPSSKVQS 533
            ....||.|... |:...||.:.|.|.||||....:||: ||||:.||:.|.|::.||||:||::|
Mouse   498 QLTGSAAPGTG-KKAPHKPLLVEGPGEDSNTAKTMFKR-KQKTNATRECFHRNAQSKKPASKLKS 560

Human   534 APCPLNFPLLSTSETVWVTYRPHPSRIQE 562
            ||||||||:|  .:.|||||:|||||||:
Mouse   561 APCPLNFPVL--PKRVWVTYKPHPSRIQD 587

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PNPLA1	NP_001361552.1	Pat_PNPLA1	2..388	CDD:132858	294/436 (67%)
		GXSXG. /evidence=ECO:0000255|PROSITE-ProRule:PRU01161	51..55		3/3 (100%)
		DGA/G. /evidence=ECO:0000255|PROSITE-ProRule:PRU01161	172..174		1/1 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	290..457		65/217 (30%)
		Atrophin-1	<295..>493	CDD:460830	75/249 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	489..532		22/42 (52%)
Pnpla1	NP_001030057.1	Patatin_and_cPLA2	3..372	CDD:416256	281/368 (76%)
		GXSXG. /evidence=ECO:0000255|PROSITE-ProRule:PRU01161	51..55		3/3 (100%)
		DGA/G. /evidence=ECO:0000255|PROSITE-ProRule:PRU01161	172..174		1/1 (100%)
		PTZ00449	<282..573	CDD:185628	113/317 (36%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	289..563		100/298 (34%)