Protein Alignment PNPLA1 and dob

DIOPT Version :10

• Sequence 1: NP_001361552.1
• Gene: PNPLA1 / 285848
• HGNCID: 21246
• Length: 572
• Species: Homo sapiens
• Sequence 2: NP_572995.1
• Gene: dob / 32436
• FlyBaseID: FBgn0030607
• Length: 480
• Species: Drosophila melanogaster
• Alignment Length: 508
• Identity: 143/508 - (28%)
• Similarity: 235/508 - (46%)
• Gaps: 77/508 - (15%)

Human    12 TPHSISFSGSGFLSFYQAGAVDALRDLAPRMLETAHRFAGTSAGAVIAALAICGIEMD----EYL 72
            |..|:||||.|||..|..|....||..||::|  ..|.||.||||:.|...||.:.::    ::|
  Fly     5 TRRSLSFSGCGFLGIYHVGVAVCLRQHAPQLL--LERIAGASAGALAACCLICDLPLECMAGDFL 67

Human    73 RVLNVGVAEVKKSFLGPLSPSCKMVQMMRQFLYRVLPEDSYKVTTGKLHVSLTRLTDGENVVVSE 137
            ||    |.|:::..||..||...:.:.:.:.:...||||::.:.:|:||:||||::|..|||:||
  Fly    68 RV----VQEIQRHSLGAFSPWFNLPECLLEGMRSWLPEDAHLLASGRLHISLTRVSDRRNVVMSE 128

Human   138 FTSKEELIEALYCSCFVPVYCGLIPPTYRGVRYIDGGFTGMQPCAFWTDAITISTFSGQQDICPR 202
            |:|::||::||.||||:|...||:||..|||||:||.|:...| ......:|:|.|.|:.|||||
  Fly   129 FSSRQELLQALMCSCFIPGLSGLVPPQVRGVRYMDGAFSDNLP-LLDEHTVTVSPFCGESDICPR 192

Human   203 D-CPAIFH-DFRMFNCSFQFSLENIARMTHALFPPDLVILHDYYYRGYEDAVLYLRR---LNAVY 262
            | .|.:.. :....|...:.|..|:.||...|.|.....:.::..:||:|.:.:|||   ||..:
  Fly   193 DQNPHLLQLNINWANTCIRLSRRNLRRMVRILVPGRADFMANFCQQGYDDTLQFLRRNSLLNEGF 257

Human   263 LNSSSKRVIFPRVEVYCQIELALGNECP-------------------ERSQPSLRARQASLEGAT 308
            .......:.:...::..:.||   .|.|                   :|.....|.::.:|:...
  Fly   258 KIQEKGMISWIHQQMEREKEL---RETPRDLEKVHTNRMTTNNVQHKKRRNRKQRTQRQTLQRTK 319

Human   309 QPHKEWVPKGDGRGSHGPPVSQPVQTLEFTCESPVSAPVSPLEQPPAQPLASSTPLSLSGMPPVS 373
            :..:|.:..|              ::||....:         ::...|   .||..|:..:.|::
  Fly   320 KNQQEKIRNG--------------RSLEMEIRN---------QEKNHQ---ESTNSSVENLTPIA 358

Human   374 FPAV-HKPPS--STPGSSLPTPPPGL------SPLSPQQQVQPSGSPARSLHSQAPTSPRPSLGP 429
            ...: ::||.  :..||||......|      :|...:..||..   ||.|........:|....
  Fly   359 EKRLENRPPEEHNHYGSSLMGSTWSLLRRVMFAPPLARHMVQVI---ARHLSQSLTLCDQPHFDL 420

Human   430 STVGAPQTLPRSSLSAFPAQPPVEELGQEQPQAVALLVSSKPKSAVPLVHVKE 482
            :.:.||.....|:.|. |...|:.:...::.:|..:..:|:.:|...:..|.|
  Fly   421 ALMQAPAACHPSTTSC-PPSTPLGDSDNDKVKAQCVCEASQIESEDQVAEVAE 472

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PNPLA1	NP_001361552.1	Pat_PNPLA1	2..388	CDD:132858	121/406 (30%)
		GXSXG. /evidence=ECO:0000255|PROSITE-ProRule:PRU01161	51..55		2/3 (67%)
		DGA/G. /evidence=ECO:0000255|PROSITE-ProRule:PRU01161	172..174		1/1 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	290..457		33/194 (17%)
		Atrophin-1	<295..>493	CDD:460830	36/197 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	489..532
dob	NP_572995.1	Pat_iPLA2	7..253	CDD:132857	99/252 (39%)