DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GPR34 and AstC-R1

DIOPT Version :9

Sequence 1:	NP_001091048.1	Gene:	GPR34 / 2857	HGNCID:	4490	Length:	381	Species:	Homo sapiens
Sequence 2:	NP_649040.2	Gene:	AstC-R1 / 40020	FlyBaseID:	FBgn0036790	Length:	483	Species:	Drosophila melanogaster

Alignment Length:	390	Identity:	101/390 - (25%)
Similarity:	165/390 - (42%)	Gaps:	67/390 - (17%)

- Green bases have known domain annotations that are detailed below.

Human     8 MTTTS---VSSWPYSSHRMRFIT--NH-------SDQPPQNFSAT--PNVTTCPMDEKLLSTVLT 58
            ||..|   .::| |:::...:.|  ||       :.||.::...|  |....|.......:.:.|
  Fly    17 MTADSEANATNW-YNTNESLYTTELNHRWISGSSTIQPEESLYGTDLPTYQHCIATRNSFADLFT 80

Human    59 -TSYSVIFIVGLVGNIIALYVFLGIHRKRNSIQIYLLNVAIADLLLIFCLPFRIMYHINQNKWTL 122
             ..|..:.|:||.||.:.:||.|...:.:....||:||:|:||...:..:|| ::|.:....|..
  Fly    81 VVLYGFVCIIGLFGNTLVIYVVLRFSKMQTVTNIYILNLAVADECFLIGIPF-LLYTMRICSWRF 144

Human   123 GVILCKVVGTLFYMNMYISIILLGFISLDRYIKINRSIQQRKAITTKQSIYVCCIVWMLALGGFL 187
            |..:||.......:..:.|.|.|..:|.||||.:...|...:..|...:..|..|.|..:....|
  Fly   145 GEFMCKAYMVSTSITSFTSSIFLLIMSADRYIAVCHPISSPRYRTLHIAKVVSAIAWSTSAVLML 209

Human   188 TMIILTL---KKGGHNSTMCFHYRD---KHNAKGEAIFNFILVVMFWLIF---LLIILSYIKIGK 243
            .:|:...   ::.|.|.:....:.|   ||:..     .|||.. |:|.|   |..|||:.
  Fly   210 PVILYASTVEQEDGINYSCNIMWPDAYKKHSGT-----TFILYT-FFLGFATPLCFILSFY---- 264

Human   244 NLLRISKRRSKFPNSGKYATTARNS--------FIVLIIFTICFVPYHAFRFIYISS---QLNVS 297
             .|.|.|.||..|..|..:...|.:        ..|:.::.:|::|:...:...|.|   |.::|
  Fly   265 -YLVIRKLRSVGPKPGTKSKEKRRAHRKVTRLVLTVISVYILCWLPHWISQVALIHSNPAQRDLS 328

Human   298 SCYWKEIVHKTNEIMLVLSSF---NSCLDPVMYFLMSSNIRK-----IMC---QLLFRRFQGEPS 351
            ..   ||:     |.|:|.:.   ||.::|::|..:|.|.||     ..|   |.:..:.|.|||
  Fly   329 RL---EIL-----IFLLLGALVYSNSAVNPILYAFLSENFRKSFFKAFTCMNKQDINAQLQLEPS 385

Human 352 351
Fly 386 385

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GPR34	NP_001091048.1	7tmA_GPR34-like	55..338	CDD:320276	82/311 (26%)
		TM helix 1	57..81	CDD:320276	9/24 (38%)
		TM helix 2	90..111	CDD:320276	9/20 (45%)
		TM helix 3	128..150	CDD:320276	4/21 (19%)
		TM helix 4	173..189	CDD:320276	4/15 (27%)
		TM helix 5	216..239	CDD:320276	10/25 (40%)
		TM helix 6	265..287	CDD:320276	4/29 (14%)
		TM helix 7	306..331	CDD:320276	7/27 (26%)
AstC-R1	NP_649040.2	7tm_4	88..368	CDD:304433	80/299 (27%)
AstC-R1	NP_649040.2	7tm_1	94..353	CDD:278431	72/278 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910