DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KIF4B and Kif4

DIOPT Version :9

Sequence 1:	NP_001092763.1	Gene:	KIF4B / 285643	HGNCID:	6322	Length:	1234	Species:	Homo sapiens
Sequence 2:	NP_032472.2	Gene:	Kif4 / 16571	MGIID:	108389	Length:	1231	Species:	Mus musculus

Alignment Length:	1236	Identity:	1033/1236 - (83%)
Similarity:	1115/1236 - (90%)	Gaps:	7/1236 - (0%)

- Green bases have known domain annotations that are detailed below.

Human     1 MKEEVKGIPVRVALRCRPLVPKEISEGCQMCLSFVPGETQVVVGTDKSFTYDFVFDPCTEQEEVF 65
            ||||||||||||||||||||.|||.||||.||||||||.|||||.||||||||||||.|||||||
Mouse     1 MKEEVKGIPVRVALRCRPLVSKEIKEGCQTCLSFVPGEPQVVVGNDKSFTYDFVFDPSTEQEEVF 65

Human    66 NKAVAPLIKGIFKGYNATVLAYGQTGSGKTYSMGGAYTAEQENEPTVGIIPRVIQLLFKEIDKKS 130
            |.||||||||:|||||||||||||||||||||||||||||||::..:|:||||||||||||:|||
Mouse    66 NTAVAPLIKGVFKGYNATVLAYGQTGSGKTYSMGGAYTAEQEHDSAIGVIPRVIQLLFKEINKKS 130

Human   131 DFEFTLKVSYLEIYNEEILDLLCPSREKA-QINIREDPKEGIKIVGLTEKTVLVALDTVSCLEQG 194
            |||||||||||||||||||||||.||||| |||||||||||||||||||||||||.|||||||||
Mouse   131 DFEFTLKVSYLEIYNEEILDLLCSSREKATQINIREDPKEGIKIVGLTEKTVLVASDTVSCLEQG 195

Human   195 NNSRTVASTAMNSQSSRSHAIFTISIEQRKKSDKNCSFRSKLHLVDLAGSERQKKTKAEGDRLKE 259
            |||||||||||||||||||||||||||||||:|||.|||||||||||||||||||||||||||:|
Mouse   196 NNSRTVASTAMNSQSSRSHAIFTISIEQRKKNDKNSSFRSKLHLVDLAGSERQKKTKAEGDRLRE 260

Human   260 GININRGLLCLGNVISALGDDKKGSFVPYRDSKLTRLLQDSLGGNSHTLMIACVSPADSNLEETL 324
            ||||||||||||||||||||||||:||||||||||||||||||||||||||||||||||||||||
Mouse   261 GININRGLLCLGNVISALGDDKKGNFVPYRDSKLTRLLQDSLGGNSHTLMIACVSPADSNLEETL 325

Human   325 STLRYADRARKIKNKPIVNIDPHTAELNHLKQQVQQLQVLLLQAHGGTLPGSINAEPSENLQSLM 389
            :||||||||||||||||:||||..||||||||||||||:||||||||||||.||.||||||||||
Mouse   326 NTLRYADRARKIKNKPIINIDPQAAELNHLKQQVQQLQILLLQAHGGTLPGDINVEPSENLQSLM 390

Human   390 EKNQSLVEENEKLSRCLSKAAGQTAQMLERIILTEQVNEKLNAKLEELRQHVACKLDLQKLVETL 454
            |||||||||||||||.||:|||||||||||||||||.|||:||||||||:|.|||:|||||||||
Mouse   391 EKNQSLVEENEKLSRGLSEAAGQTAQMLERIILTEQANEKMNAKLEELRRHAACKVDLQKLVETL 455

Human   455 EDQELKENVEIICNLQQLITQLSDETVACTAAAIDTAVEEEAQVETSPETSRSSDAFTTQHALHQ 519
            ||||||||:||||||||:|.|||||..||..|.||||.|.:.||::||:||||||.|:|||||.|
Mouse   456 EDQELKENIEIICNLQQVIAQLSDEAAACMTATIDTAGEADTQVQSSPDTSRSSDVFSTQHALRQ 520

Human   520 AQMSKEVVELNNALALKEALVRKMTQNDNQLQPIQFQYQDNIKNLELEVINLQKEKEELVRELQT 584
            ||||||::|||.||||||||.:||||||||||||||||||||||||.||::||:||||||.||||
Mouse   521 AQMSKELIELNKALALKEALAKKMTQNDNQLQPIQFQYQDNIKNLESEVLSLQREKEELVLELQT 585

Human   585 AKKNVNQAKLSEHRHKLLQELEGQIADLKKKLNEQSKLLKLKESTERTVSKLNQEIWMMKNQRVQ 649
            |||:.|||||||.|.|.|||||||||||||||.|||||||||||||.|||||||||.||||||||
Mouse   586 AKKDANQAKLSERRRKRLQELEGQIADLKKKLQEQSKLLKLKESTEHTVSKLNQEIRMMKNQRVQ 650

Human   650 LMRQMKEDAEKFRQWKQKKDKEVIQLKERDRKRQYELLKLERNFQKQSSVLRRKTEEAAAANKRL 714
            |||||||||||||||||:||||||||||||||||||||||||||||||:||||||||||||||||
Mouse   651 LMRQMKEDAEKFRQWKQQKDKEVIQLKERDRKRQYELLKLERNFQKQSNVLRRKTEEAAAANKRL 715

Human   715 KDALQKQREVTDKRKETQSHGKEGIAARVRNWLGNEIEVMVSTEEAKRHLNDLLEDRKILAQDVV 779
            |||||||:||.:|||||||.|.|..|||::|||||||||||||||||||||.|||:||||||||.
Mouse   716 KDALQKQKEVAEKRKETQSRGMESTAARMKNWLGNEIEVMVSTEEAKRHLNGLLEERKILAQDVA 780

Human   780 QLKEKKESRENPPPKLRKCTFSLSEVHGQVLESEDCITKQIESLETEMELRSAQIADLQQKLLDA 844
            |||||:||.||||.|||:.|||..|:|||...:||.|.|||||||||:|||||||||||||||||
Mouse   781 QLKEKRESGENPPLKLRRRTFSYDEIHGQDSGAEDSIAKQIESLETELELRSAQIADLQQKLLDA 845

Human   845 ESEDRPKQCWENIATILEAKCALKYLIGELVSSKIHVTKLENSLRQSKASCADMQKMLFEEQNHF 909
            ||||||||.||:||||||||||:|||:||||||||.|:|||:||.||||||.|:|||||||||||
Mouse   846 ESEDRPKQRWESIATILEAKCAIKYLVGELVSSKILVSKLESSLNQSKASCIDVQKMLFEEQNHF 910

Human   910 SEIETELQAELVRMEQQHQEKVLYLVSQLQESQMAEKQLEKSASEKEQQLVSTLQCQDEELEKMR 974
            ::|||||:.|||::|||||||||||:||||:|||.|||||:|.|||||||:|||:||:|||.||:
Mouse   911 AKIETELKEELVKVEQQHQEKVLYLLSQLQQSQMTEKQLEESVSEKEQQLLSTLKCQEEELRKMQ 975

Human   975 EVCEQNQQLLQENEIIKQKLILLQVASRQK-HLPNDTLLSPDSSFEYIPPKPKPSRVKEKFLEQS 1038
            |||||||||||||..|||||.||||||:|| ||..:...|||||||||||||||.|:|||.||||
Mouse   976 EVCEQNQQLLQENSAIKQKLTLLQVASKQKPHLTRNIFQSPDSSFEYIPPKPKPCRIKEKCLEQS 1040

Human  1039 MDIEDLKYCSEHSVNEHEDGDGDGDSDEGDDEEWKPTKLVKVSRKNIQGCSCKGWCGNKQCGCRK 1103
            ..:|.|:|.||.||.|.:    :.|||:..||||.||||||||:|:|||||||||||||||||||
Mouse  1041 FAVEGLQYYSEPSVAEQD----NEDSDDHADEEWIPTKLVKVSKKSIQGCSCKGWCGNKQCGCRK 1101

Human  1104 QKSDCGVDCSCDPTKCRNRQQGKDSLGTVEQTQDSEGSFKLEDPTEVTPGLSFFNPVCATPNSKI 1168
            |||||.|.|||||||||||.|.:|:...:|..||||.|||||||||||.|||||:|:||||:|||
Mouse  1102 QKSDCNVSCSCDPTKCRNRHQNQDNSDAIELNQDSENSFKLEDPTEVTSGLSFFHPICATPSSKI 1166

Human  1169 LKEMCDMEQVLSKKTAPAPSPFDLPESKHGATEYQQNKPPGKKKKRALASNTSFFSGCSPIEEEA 1233
            ||||||.:||..|:.....|. |.||.|..|:|.|:||..|||||||||||||||||||||:||:
Mouse  1167 LKEMCDADQVQLKQPVFVSSS-DHPELKSIASESQENKAIGKKKKRALASNTSFFSGCSPIQEES 1230

Human  1234 H 1234
            |
Mouse  1231 H 1231

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KIF4B	NP_001092763.1	KISc_KIF4	8..337	CDD:276823	306/329 (93%)
		KISc	9..343	CDD:214526	311/334 (93%)
		SbcC	406..995	CDD:223496	489/588 (83%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	494..513		11/18 (61%)
		Interaction with PRC1. /evidence=ECO:0000250\|UniProtKB:O95239	663..1234		441/571 (77%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	712..737		20/24 (83%)
		Nuclear localization signal. /evidence=ECO:0000250\|UniProtKB:O95239	793..798		3/4 (75%)
		Globular. /evidence=ECO:0000250	1000..1234		162/234 (69%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1007..1030		15/22 (68%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1052..1076		10/23 (43%)
		Pre-SET	<1072..1122	CDD:282838	44/49 (90%)
		CRD, required for [4Fe-4S] cluster binding and localization to the spindle midzone and midbody during anaphase and telophase. /evidence=ECO:0000250\|UniProtKB:O95239	1086..1144		44/57 (77%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1122..1143		9/20 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1183..1234		33/50 (66%)
Kif4	NP_032472.2	KISc_KIF4	8..338	CDD:276823	306/329 (93%)
		KISc	9..344	CDD:214526	311/334 (93%)
		SbcC	407..995	CDD:223496	488/587 (83%)
		Globular	1001..1231		162/234 (69%)
		Pre-SET	<1070..1120	CDD:282838	44/49 (90%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1189..1212		13/22 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	1466	1.000	Domainoid score	I692
eggNOG	1	0.900	-	-		E2759_KOG0244
HGNC	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	2089	1.000	Inparanoid score	I1442
Isobase	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D369179at2759
OrthoFinder	1	1.000	-	-		FOG0003140
OrthoInspector	1	1.000	-	-		otm51897
orthoMCL	1	0.900	-	-		OOG6_100464
Panther	1	1.100	-	-	O	PTHR47969
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3568
SonicParanoid	1	1.000	-	-		X2108
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.860