DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SH3PXD2B and sh3pxd2b

DIOPT Version :9

Sequence 1:	XP_016864840.1	Gene:	SH3PXD2B / 285590	HGNCID:	29242	Length:	939	Species:	Homo sapiens
Sequence 2:	XP_005170345.1	Gene:	sh3pxd2b / 553242	ZFINID:	ZDB-GENE-060810-52	Length:	880	Species:	Danio rerio

Alignment Length:	977	Identity:	530/977 - (54%)
Similarity:	629/977 - (64%)	Gaps:	138/977 - (14%)

- Green bases have known domain annotations that are detailed below.

Human     3 PRRSIVEVKVLDVQKRRVPNKHYVYIIRVTWSSGSTEAIYRRYSKFFDLQMQMLDKFPMEGGQKD 67
            |||:::||.|.||||||.|||||||||:|.||.||||.|:|||||||||||::|||||:||||||
Zfish     2 PRRTVLEVTVQDVQKRRNPNKHYVYIIKVAWSDGSTEVIFRRYSKFFDLQMELLDKFPVEGGQKD 66

Human    68 PKQRIIPFLPGKILFRRSHIRDVAVKRLIPIDEYCKALIQLPPYISQCDEVLQFFETRPEDLNPP 132
            ||:|||||||||||||||||||||:|||.||:|||:||||||.|||||:||..||||||||||||
Zfish    67 PKRRIIPFLPGKILFRRSHIRDVAMKRLKPINEYCRALIQLPVYISQCEEVRVFFETRPEDLNPP 131

Human   133 KEEHIGKKKS------------GGDQTSVDPMVLEQYVVVANYQKQESSEISLSVGQVVDIIEKN 185
            |||..|||||            |||.:|.||::|:|||.|.:|:|||||||||.|||||::||||
Zfish   132 KEEPSGKKKSGIVERASSFLKRGGDSSSADPLLLDQYVAVTDYEKQESSEISLYVGQVVEVIEKN 196

Human   186 ESGWWFVSTAEEQGWVPATCLEGQDGVQDEFSLQPEEVSWRYWSLPRPVGRRRTLGDLYAISWRQ 250
            |||||||||.:.||||||||||.||. .|:|||..||
Zfish   197 ESGWWFVSTEDAQGWVPATCLEAQDD-PDDFSLPAEE---------------------------- 232

Human   251 EEKYTVIYPYTARDQDEMNLERGAVVEVIQKNLEGWWKIRYQGKEGWAPASYLKKNSGEPLPPKP 315
            |||||.||||:||||||::||||..||||||||||||||||||||||||||||||  .:.|..|.
Zfish   233 EEKYTAIYPYSARDQDEIDLERGMTVEVIQKNLEGWWKIRYQGKEGWAPASYLKK--ADILSQKM 295

Human   316 GPGSPSHPGALDLDGVSRQQNAVGREKELLSSQRDGRFEGRPVPDGDAKQRSPKMRQRPPPRRDM 380
            ..|:|.|....|||...:||||   .||...:||| ||.    |..|:| |....|||||||||:
Zfish   296 AAGAPVHASTNDLDVACKQQNA---NKENKENQRD-RFS----PFSDSK-RKVGARQRPPPRRDL 351

Human   381 TIPRGLNLPKPPIPPQVEEEYYTIAEFQTTIPDGISFQAGLKVEVIEKNLSGWWYIQIEDKEGWA 445
            |||||:||||||:||||||||||||:|||||||||||||||||||||||.|||||||||||||||
Zfish   352 TIPRGVNLPKPPVPPQVEEEYYTIADFQTTIPDGISFQAGLKVEVIEKNSSGWWYIQIEDKEGWA 416

Human   446 PATFIDKYKKTSNASRPNFLAPLPHEVTQLRLGEAAALENNTGSEATGPSRPLPDAPHGVMD-SG 509
            |.||||||||||:|||||||||||.|:.||:|.:.::  |:|.||.|. |:||||.|....| |.
Zfish   417 PVTFIDKYKKTSSASRPNFLAPLPGEMEQLKLEDTSS--NSTNSEHTW-SKPLPDEPSSNSDLST 478

Human   510 LPWSKDWKGSKDVLRKASSDMSASAGYEEISDPDMEEKPSLPPRKESIIKSEGELLERERERQRT 574
            ....::||.:   ..|:||..|.... ...|.|..||||:||||:|||.||    ||.| ::.:.
Zfish   479 RSKLREWKPN---AAKSSSHFSGPLP-PPPSSPTAEEKPALPPRRESINKS----LELE-DKPKA 534

Human   575 EQLRGPTPKP--PGVILPMMPAKHIPPARDSRRPEPKPDKSRLFQLKNDMGLECGHKVLAKEVKK 637
            |..:...|||  ||||.|::..|..|...|......|.||::...|:|:|||||||.:..|||||
Zfish   535 ELSKPLPPKPPVPGVIAPLVTPKAAPLKPDKPPEMKKDDKNKQLFLRNEMGLECGHNISVKEVKK 599

Human   638 PNLR-----PISKSKTDLPEEKPDATPQNPFLKSRPQVRPKPAPSPKTEPPQGEDQVDICNLRSK 697
            .||:     |.:|.|.||.|:||::....||||.:|.:||||||:.|.| |..::::||.|||||
Zfish   600 FNLKHVAKQPPTKPKPDLQEDKPESPNPAPFLKPKPVIRPKPAPAAKPE-PVAKNELDITNLRSK 663

Human   698 LRPAKSQDKSLLDGEGPQAVGGQDVAFSRSFLPGEGPGRAQDRTGKQDGLSPKEISCRAPPRPAK 762
            |||:|..:.:..|       ..|....|.|..|.      ..||.::....||:.:...   |::
Zfish   664 LRPSKPPELNSSD-------ANQQNDTSSSSPPN------NSRTNEEPKCLPKQQNGHG---PSE 712

Human   763 TTDPVSKSVPVPLQEAPQQRPVVPPRRPPPPKKTSSSSRPLPEVRGPQCEGHESRAAPTPGRALL 827
            ||.|         .:.|.|||.|.|||||||||:|..:.| .:.|.||.:..|::.||.| ::..
Zfish   713 TTKP---------PKEPPQRPSVAPRRPPPPKKSSEPASP-TDTRAPQKDLPEAKPAPPP-QSRP 766

Human   828 VPPKAKPFLSNSLGGQDDTRGKGSLGPWGTGKIGENREKAAAASV------------PNADGL-- 878
            .|||.|.|                  |....|..|..|......|            |..|.|
Zfish   767 PPPKTKAF------------------PLPAPKDKEKEEPKPKVPVPPKPLVKPDKPGPPRDKLPP 813

Human   879 ------KDSLYVAVADFEGDKDTSSFQEGTVFEVREKNSSGWWFCQVLSGAPSWEGWIPSNYLRK 937
                  |:.|::||||||||:.|..|:||.||||.|:|:||||||:.:|..|..|||||||||.|
Zfish   814 LIKEPSKEELFLAVADFEGDEQTPGFKEGAVFEVMERNTSGWWFCKNVSDGPVMEGWIPSNYLTK 878

Human   938 KP 939
            ||
Zfish   879 KP 880

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SH3PXD2B	XP_016864840.1	None
sh3pxd2b	XP_005170345.1	PX_FISH	6..124	CDD:132798	95/117 (81%)
		SH3_Tks4_1	166..220	CDD:213008	42/53 (79%)
		SH3_Tks4_2	234..287	CDD:213009	46/52 (88%)
		SH3_Tks4_3	371..423	CDD:213011	48/51 (94%)
		SH3_Tks4_4	823..878	CDD:212951	36/54 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194339078
Domainoid	1	1.000	236	1.000	Domainoid score	I10438
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H27952
Inparanoid	1	1.050	931	1.000	Inparanoid score	I2654
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG38893
OrthoDB	1	1.010	-	-		D1183210at2759
OrthoFinder	1	1.000	-	-		FOG0011646
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_110342
Panther	1	1.100	-	-	LDO	PTHR15706
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X9356
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	1	1.500	-	-
	14	14.410