DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SH3PXD2B and piki-1

DIOPT Version :9

Sequence 1:	XP_016864840.1	Gene:	SH3PXD2B / 285590	HGNCID:	29242	Length:	939	Species:	Homo sapiens
Sequence 2:	NP_510529.1	Gene:	piki-1 / 181618	WormBaseID:	WBGene00009552	Length:	1607	Species:	Caenorhabditis elegans

Alignment Length:	189	Identity:	43/189 - (22%)
Similarity:	83/189 - (43%)	Gaps:	21/189 - (11%)

- Green bases have known domain annotations that are detailed below.

Human     7 IVEVKVLDVQKRRVPNKHYVYIIRVTWSSGSTEA-IYRRYSKFFDLQMQMLDKFPMEGGQKDPKQ 70
            |..|.||..:|..:|||.|:|.:.|...:.:..: |||.:::|.:|..::..:|||.....:...
Worm  1346 ISRVTVLKFEKHCIPNKIYMYKVEVHRKNVAVSSFIYRSFAEFEELHTKLRARFPMMAVSLNTIS 1410

Human    71 RIIPFLPGKILFRRSHIRDVAVKRLIPIDEYCKALIQLPPYISQCDEVLQFFETRPEDLNPPKEE 135
            .:           ||::|.||.||:|.:.::...|......|..||.|..||.:...|
Worm  1411 NL-----------RSNVRAVAQKRIIHVQKFLIYLFNQVDEICHCDLVYTFFHSILRD------- 1457

Human   136 HIGKKKSGGDQTSVDPMVLEQYVVVANYQKQESSEISLSVGQVVDIIEKNESGWWFVST 194
              .|..:..|::...|...:.|:.:.....:|:..:.:...:.:.:::.|:....:|.|
Worm  1458 --NKCDTYIDESLDMPSQCQIYLKIEYNSVKETLSVFIGHAKYLALLQNNQQPDPYVKT 1514

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SH3PXD2B	XP_016864840.1	None
piki-1	NP_510529.1	PI3K_rbd	348..456	CDD:197540
		C2A_PI3K_class_II	593..775	CDD:175979
		PI3Ka_II	784..948	CDD:238441
		PI3Kc_II	964..1315	CDD:270710
		PX_domain	1346..1454	CDD:295365	34/118 (29%)
		C2B_PI3K_class_II	1473..1604	CDD:176027	5/42 (12%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900