Protein Alignment CCDC66 and CG13251

DIOPT Version :10

• Sequence 1: NP_001340076.1
• Gene: CCDC66 / 285331
• HGNCID: 27709
• Length: 954
• Species: Homo sapiens
• Sequence 2: NP_649246.1
• Gene: CG13251 / 40286
• FlyBaseID: FBgn0037014
• Length: 1088
• Species: Drosophila melanogaster
• Alignment Length: 642
• Identity: 131/642 - (20%)
• Similarity: 234/642 - (36%)
• Gaps: 194/642 - (30%)

Human   423 HIAKPIKDVVMANSKKTNFLRSMTALLDPAQIEERDRRRQKQLEHQKAITAQVEEKRRKKQLEEE 487
            |..|..:|.|.:....:.:||...|.||...:.||..:|:|..|:..||..|:.|:...::.|.|
  Fly   445 HDLKDSEDDVQSMQSSSTYLRGQNAPLDAHTLAERMDKRRKAAEYHNAIKKQLHERELIRKWEHE 509

Human   488 QRKKEEQEEELRLAQEREEMQKQYEEDILKQKQKEEIMTLKTNELFQTMQRAQELAQRLKQEQR- 551
            :.::|||.||.|:.::::..|::.|.:....:::||....|...:...:|:|:..|:..:|::|
  Fly   510 RHRQEEQIEEERIRRQKQLEQERLEFERRTLQEREEAQQKKQQVMLDAIQKAEVAAKMERQKRRM 574

Human   552 IRELAQKGHDT----SRLIKNLGGDFSLPVDTIQMEYNASNISNSRHDSDEISGKMN-TYMNSTT 611
            :|:.::...:|    |.||:         |.:::.|          .|::|.||.:. ......|
  Fly   575 VRQPSKVSQETEEDESELIR---------VQSVEEE----------EDAEEKSGAVEPPSQEEET 620

Human   612 SKKDTG----VQTDDLNIGIFTNAESHCGSLMERDITN-CSSPEISAELIGQFSTKKNKQELTQD 671
            |....|    :..:.:.||...|        :.|.||. ...|        :.|.|::.:|.||.
  Fly   621 SNTPRGAPPVMSEEKVLIGTPIN--------LRRTITKPIKQP--------RDSRKEDPKEPTQT 669

Human   672 KGASL----EKENNRCNDQ----------------CNQFTRIEKQTKHMKKYPKRPDWNINKPPK 716
            |..:.    :|||.....|                .|....::..|..|:.       .:.|||:
  Fly   670 KVQTTFLGEDKENVALLMQPATLIPLPVTSDIFGLQNAIGNLQIATYFMQP-------PMQKPPE 727

Human   717 RYIPASEKYPK-----------------QLQKQREEKKVRR------------------------ 740
              .|.|  |.|                 |.:|:.:.....|
  Fly   728 --TPGS--YSKATMTHRTDTSIYTEDGYQAEKEEDPLTTARSGRTDLVTASGCFSPDSLEVDVAP 788

Human   741 ----QMELLHLVEKNNPGHL-----SQNRG-ISPEIFHSSHQETESKLRWHLVKKEEEPLN---- 791
                :.:.|.|:....|..|     |.:|| .:.|:.|.:..||:::|          |||
  Fly   789 VLIAETDKLALIPLKTPLQLGISNSSDDRGEHNHEVGHQADVETQTEL----------PLNCDLC 843

Human   792 -IHS------FSKERSPSSPVPVVKNRTQQTQNTLHLPLKNSSYERENLISGSNQTELSSGI--- 846
             .|.      ..:|.|.::.....|::||        |.|.|:.|:::..:.:..|..::..
  Fly   844 LFHDNFYKVLLKREVSTTTTTQTSKSQTQ--------PAKESTAEKDHETTTTTTTTTTTTFKAK 900

Human   847 SESSHFIPYVRTN-----EIYYLDPDAPLSGPSTQDPQYQNSQDCGQKRQLFDSDCVRDPLLNPN 906
            |:.......::.|     :...:| |.|..|.:....||..:.|       .|..|:|....:|:
  Fly   901 SKDKDKEKNLKRNLNKDKDANKMD-DRPKWGVNRPVVQYVKASD-------RDPFCLRKKKNHPS 957

Human   907 MVK----------------NRDRQQAILKG----LSEL-RQGLLQKQKELESSLLPL 942
            ..|                ..||...|..|    ..|| .:|.|.|.:.:.:.:||:
  Fly   958 TAKPPRSLSMDSRLDSVALPEDRLINIAGGPPSAAGELEEEGFLLKARNVCTEILPI 1014

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CCDC66	NP_001340076.1	CCDC66	411..564	CDD:434558	38/145 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	458..499		14/40 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	696..719		5/22 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	794..814		4/25 (16%)
CG13251	NP_649246.1	CCDC66	445..580	CDD:434558	37/134 (28%)
		PTZ00121	<472..693	CDD:173412	59/255 (23%)