DRSC/TRiP Functional Genomics Resources

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Protein Alignment GPER1 and TyrRII

DIOPT Version :9

Sequence 1:NP_001035055.1 Gene:GPER1 / 2852 HGNCID:4485 Length:375 Species:Homo sapiens
Sequence 2:NP_001262682.1 Gene:TyrRII / 42135 FlyBaseID:FBgn0038541 Length:586 Species:Drosophila melanogaster


Alignment Length:237 Identity:55/237 - (23%)
Similarity:105/237 - (44%) Gaps:27/237 - (11%)


- Green bases have known domain annotations that are detailed below.


Human    39 GTALANGTGE----LSEHQQYVIGL----FLSCLYTIFLFPIGFVGNILILVVNISFREKMTIPD 95
            |..:|.|.|.    :.....|::.:    .|:....:.:..:..|||.|:::..::.|...|:.:
  Fly    46 GDVMATGAGAGKLGVPSMNSYLVSMAWPKSLAVAVFLVIILVTVVGNTLVILAVLTTRRLRTVTN 110

Human    96 LYFINLAVADLI----LVADSLIEVFNLHERYYDIAVLCTFMSLFLQVNMYS-SVFFLTWMSFDR 155
            .:.:|||:.|.:    ::..|::.......|:.  .:||... :.|.:.:.| |:..|..:|.||
  Fly   111 CFVMNLAITDWLVGTCVMPPSVVLYITGTWRFG--WILCDIW-ISLDILLCSGSILSLCAISLDR 172

Human   156 YIALARAMRCS-LFRTKHHARLSCGLIWMASVSATLVPFTAVHL--QHTDEACFCFADVREVQWL 217
            |:|:.:.:..| ..|:|..|.|...::|:.::|.|..|:...:.  :|..|    |.|.|..|  
  Fly   173 YLAVTQPLTYSKKRRSKRLALLMILVVWITALSITCPPYLGWYEVGRHQAE----FVDCRYNQ-- 231

Human   218 EVTLGFIVPFAIIGLCYSLIVRVLVRAHRHRGLRPRRQKALR 259
              ..|::|..|:......|.|.:.|.......|..|||:.:|
  Fly   232 --NKGYVVFSAMGSFFIPLTVMLYVYVKIGYVLTSRRQRIVR 271

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GPER1NP_001035055.1 7tmA_GPER1 60..335 CDD:320120 50/208 (24%)
TM helix 1 62..86 CDD:320120 4/23 (17%)
TM helix 2 95..116 CDD:320120 5/24 (21%)
TM helix 3 131..153 CDD:320120 4/22 (18%)
TM helix 4 176..192 CDD:320120 4/15 (27%)
TM helix 5 212..235 CDD:320120 5/22 (23%)
TM helix 6 258..280 CDD:320120 1/2 (50%)
TM helix 7 303..328 CDD:320120
TyrRIINP_001262682.1 7tm_4 82..>212 CDD:304433 32/132 (24%)
7tm_1 91..>277 CDD:278431 48/192 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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