DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GPER1 and Dop1R1

DIOPT Version :9

Sequence 1:	NP_001035055.1	Gene:	GPER1 / 2852	HGNCID:	4485	Length:	375	Species:	Homo sapiens
Sequence 2:	NP_001262563.1	Gene:	Dop1R1 / 41726	FlyBaseID:	FBgn0011582	Length:	560	Species:	Drosophila melanogaster

Alignment Length:	424	Identity:	102/424 - (24%)
Similarity:	169/424 - (39%)	Gaps:	99/424 - (23%)

- Green bases have known domain annotations that are detailed below.

Human    15 YPGTAQPAAPNTTSPELNLSHPLLGTALANGTGELSEHQQYVIGLFLSCLYTIFLFPIGFVGNIL 79
            |.||...:..|.:| ..|.|.  :.|.:......||.....|:|:|||.|  |||   ...||||
  Fly    92 YDGTTLTSFYNESS-WTNASE--MDTIVGEEPEPLSLVSIVVVGIFLSVL--IFL---SVAGNIL 148

Human    80 ILVVNISFREKMTIPDLYFINLAVADLILVADSLIEVF----NLHERYYDIAVLCTFMSLFLQVN 140
            :.:...:.|....|.:|:..:||:|||.:.  ||:..|    :|...:...|..|.....|..:.
  Fly   149 VCLAIYTERSLRRIGNLFLASLAIADLFVA--SLVMTFAGVNDLLGYWIFGAQFCDTWVAFDVMC 211

Human   141 MYSSVFFLTWMSFDRYIALARAMRCSLFRTKHHARLSCGLIWMASVSATLVPFTAVHLQHTDEAC 205
            ..:|:..|..:|.||||.:...:|...:.|:..|.::...||:.:...:.||. ::.:...|:..
  Fly   212 STASILNLCAISMDRYIHIKDPLRYGRWVTRRVAVITIAAIWLLAAFVSFVPI-SLGIHRPDQPL 275

Human   206 F----------CFADVREV-QWLEVTLGFIVPFAI-IGL-----CYS----LIVRVLVR------ 243
            .          |..|:... ..:...:.|..|..: ||:     ||:    ..::.:.|
  Fly   276 IFEDNGKKYPTCALDLTPTYAVVSSCISFYFPCVVMIGIYCRLYCYAQKHVKSIKAVTRPGEVAE 340

Human   244 AHRHRGL-RPRRQ---------------------KALRMILAVVLVFFVCWLPENVFISVHLLQR 286
            ..|::.: ||:.|                     ||...:..::.||.:||:|   |..|::.
  Fly   341 KQRYKSIRRPKNQPKKFKVRNLHTHSSPYHVSDHKAAVTVGVIMGVFLICWVP---FFCVNIT-- 400

Human   287 TQPGAAPCK-----QSFRHAHPLTGHIVNLAAFSNSCLNPLIYSFLGETFRDKLRLYIEQKT--- 343
                ||.||     |:|:        |:....:|||..||:|||...:.|||..:..:..:.
  Fly   401 ----AAFCKTCIGGQTFK--------ILTWLGYSNSAFNPIIYSIFNKEFRDAFKRILTMRNPWC 453

Human   344 ------NLPALN--RFC--HAALKAVIPDSTEQS 367
                  |:...|  ||.  :||...|:.:|...|
  Fly   454 CAQDVGNIHPRNSDRFITDYAAKNVVVMNSGRSS 487

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GPER1	NP_001035055.1	7tmA_GPER1	60..335	CDD:320120	81/332 (24%)
		TM helix 1	62..86	CDD:320120	9/23 (39%)
		TM helix 2	95..116	CDD:320120	8/20 (40%)
		TM helix 3	131..153	CDD:320120	3/21 (14%)
		TM helix 4	176..192	CDD:320120	2/15 (13%)
		TM helix 5	212..235	CDD:320120	5/29 (17%)
		TM helix 6	258..280	CDD:320120	6/21 (29%)
		TM helix 7	303..328	CDD:320120	9/24 (38%)
Dop1R1	NP_001262563.1	7tm_4	134..>266	CDD:304433	40/139 (29%)
Dop1R1	NP_001262563.1	7tm_1	145..431	CDD:278431	68/305 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910