DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GPER1 and TkR86C

DIOPT Version :9

Sequence 1:	NP_001035055.1	Gene:	GPER1 / 2852	HGNCID:	4485	Length:	375	Species:	Homo sapiens
Sequence 2:	NP_001097741.1	Gene:	TkR86C / 41286	FlyBaseID:	FBgn0004841	Length:	555	Species:	Drosophila melanogaster

Alignment Length:	314	Identity:	82/314 - (26%)
Similarity:	145/314 - (46%)	Gaps:	62/314 - (19%)

- Green bases have known domain annotations that are detailed below.

Human    64 LYTIFLFPIGFVGNILILVVNISFREKMTIPDLYFINLAVADLILVADSLIEVFN----LHERYY 124
            ::.:.:| :...||.::|.:....|...|:.:.:.:||::|||::  .||..|||    |:..:.
  Fly    89 IFGLMMF-VAIAGNGIVLWIVTGHRSMRTVTNYFLLNLSIADLLM--SSLNCVFNFIFMLNSDWP 150

Human   125 DIAVLCTFMSLFLQVNMYSSVFFLTWMSFDRYIALARAMRCSLFRTKHHARLSCGLIWMAS--VS 187
            ..::.||..:....|.:.:|||.|..:|||||||:...::....|.|  .|:...|||..|  :|
  Fly   151 FGSIYCTINNFVANVTVSTSVFTLVAISFDRYIAIVHPLKRRTSRRK--VRIILVLIWALSCVLS 213

Human   188 ATLVPFTAVHLQH-----TDEACFCFADVREVQW------------------LEVTLGFIVPFAI 229
            |..:.::::..:|     :...||       :.|                  |.:|.|  :|..:
  Fly   214 APCLLYSSIMTKHYYNGKSRTVCF-------MMWPDGRYPTSMADYAYNLIILVLTYG--IPMIV 269

Human   230 IGLCYSLIVRVL-------VRAHRHRGLRPRRQKALRMILAVVLVFFVCWLPENVFISVHLLQRT 287
            :.:||||:.|||       ....|.......::|.:||.:|:|.:|.:||||.::|. ::.....
  Fly   270 MLICYSLMGRVLWGSRSIGENTDRQMESMKSKRKVVRMFIAIVSIFAICWLPYHLFF-IYAYHNN 333

Human   288 QPGAAPCKQSFRHAHPLTGHIVNLAAFSNSCLNPLIYSFLGETFRDKLRLYIEQ 341
            |..:....|     |...|..  ..|.||:.:|||||.::.:.|    |:|.::
  Fly   334 QVASTKYVQ-----HMYLGFY--WLAMSNAMVNPLIYYWMNKRF----RMYFQR 376

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GPER1	NP_001035055.1	7tmA_GPER1	60..335	CDD:320120	80/306 (26%)
		TM helix 1	62..86	CDD:320120	4/21 (19%)
		TM helix 2	95..116	CDD:320120	7/20 (35%)
		TM helix 3	131..153	CDD:320120	6/21 (29%)
		TM helix 4	176..192	CDD:320120	6/17 (35%)
		TM helix 5	212..235	CDD:320120	6/40 (15%)
		TM helix 6	258..280	CDD:320120	10/21 (48%)
		TM helix 7	303..328	CDD:320120	9/24 (38%)
TkR86C	NP_001097741.1	7tm_4	92..376	CDD:304433	82/309 (27%)
TkR86C	NP_001097741.1	7tm_1	100..363	CDD:278431	76/283 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910