DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GPER1 and CNMaR

DIOPT Version :9

Sequence 1:	NP_001035055.1	Gene:	GPER1 / 2852	HGNCID:	4485	Length:	375	Species:	Homo sapiens
Sequence 2:	NP_001027122.2	Gene:	CNMaR / 39127	FlyBaseID:	FBgn0053696	Length:	480	Species:	Drosophila melanogaster

Alignment Length:	237	Identity:	57/237 - (24%)
Similarity:	89/237 - (37%)	Gaps:	62/237 - (26%)

- Green bases have known domain annotations that are detailed below.

Human    25 NTTSPELNLSHPLLGTALANGTGELSEHQQ--YVIGLFLSCLYTIFLFPIGFVGNILILVVNISF 87
            |||..:.|.|           .||..|..:  :.||.|:...|...|...|.:||||.:.|....
  Fly    34 NTTEMDANES-----------AGEDEEMLRIAFFIGHFVHQYYIPVLCCTGSIGNILSVFVFFRT 87

Human    88 REKMTIPDLYFINLAVADLILVADSLIEVFN-LHERYYDIAVLCTFMSLFLQVNMYSSVFFLTWM 151
            :.:......|...|||:|...:|....:..| |:...|:....|.|.:.|..:..:.||:|:...
  Fly    88 KLRKLSSSFYLAALAVSDTCFLAGLFAQWLNFLNVDIYNQNYFCQFFTFFSYLASFCSVWFVVAF 152

Human   152 SFDRYIA----LARAMRCSLFRTKHHARLSC----GL------------IWMASVSATL------ 190
            :.:|:||    |.|...|::.|.|  ..|.|    |.            ::|..::.|:
  Fly   153 TVERFIAVIYPLKRQTMCTVRRAK--IVLFCLTLVGCLHCLPYIVIAKPVFMPKLNTTICDLNSE 215

Human   191 ------------------VPFTAVHLQHTDEAC--FCFADVR 212
                              ||||.:.:.:|...|  :.||.||
  Fly   216 YKEQLALFNYWDTIVVYAVPFTTIAVLNTCTGCTVWKFATVR 257

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GPER1	NP_001035055.1	7tmA_GPER1	60..335	CDD:320120	47/200 (24%)
		TM helix 1	62..86	CDD:320120	8/23 (35%)
		TM helix 2	95..116	CDD:320120	6/20 (30%)
		TM helix 3	131..153	CDD:320120	5/21 (24%)
		TM helix 4	176..192	CDD:320120	5/55 (9%)
		TM helix 5	212..235	CDD:320120	1/1 (100%)
		TM helix 6	258..280	CDD:320120
		TM helix 7	303..328	CDD:320120
CNMaR	NP_001027122.2	7tm_4	73..>262	CDD:304433	44/187 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910