DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GPER1 and Octbeta3R

DIOPT Version :9

Sequence 1:	NP_001035055.1	Gene:	GPER1 / 2852	HGNCID:	4485	Length:	375	Species:	Homo sapiens
Sequence 2:	NP_001034048.2	Gene:	Octbeta3R / 3885573	FlyBaseID:	FBgn0250910	Length:	1256	Species:	Drosophila melanogaster

Alignment Length:	362	Identity:	72/362 - (19%)
Similarity:	125/362 - (34%)	Gaps:	118/362 - (32%)

- Green bases have known domain annotations that are detailed below.

Human     1 MDVTSQARGVGLEMYPGTAQPAAPNTTSP-----ELNLSHPLLGTA----LANGT-------GEL 49
            :.:|||.....|.....||..:..:.:||     ..:.:..||.|.    .|||:       .||
  Fly    65 LPITSQFVDASLTSLSLTATSSDASYSSPFSSYLSSDSTFELLSTVGPNITANGSDIAVDNQAEL 129

Human    50 SEHQQYVIGLFLSCLYTIFLFPIGFV----------GNILILVVNISFREKMTIPDLYF-INLAV 103
            .|          |.|....|...||:          ||.|: ::::....|:.:...|| ::||:
  Fly   130 EE----------SWLDLSLLLLKGFIFSSIILAAVLGNALV-IISVQRNRKLRVITNYFVVSLAM 183

Human   104 ADLI-------------------LVADSLIEVFNLHERYYDIAVLCTFMSLFLQVNMYSSVFFLT 149
            ||::                   :....:..|:|..:.|:..|                |:..|.
  Fly   184 ADMLVALCAMTFNASVELSGGKWMFGPFMCNVYNSLDVYFSTA----------------SILHLC 232

Human   150 WMSFDRYIALARAMRCSLFRTKHHARLSCGLIWMASVSATLVPFTAV---------HLQ----HT 201
            .:|.|||.|:.|.:...|..|..........:|   :...|:.||.:         ||:    |.
  Fly   233 CISVDRYYAIVRPLEYPLNMTHKTVCFMLANVW---ILPALISFTPIFLGWYTTEEHLREISLHP 294

Human   202 DEACFCFADVREVQWLEVTLGFIVPFAIIGLCYSLIVRVLVRAHRHRGLRPRRQKALRMILAVVL 266
            |:..|...  :....:..::.|.:|..::.:.|..|.:..:          |::|||....:.:|
  Fly   295 DQCSFVVN--KAYALISSSVSFWIPGIVMLVMYWRIFKEAI----------RQRKALSRTSSNIL 347

Human   267 VFFVCWLPENVFISVHLLQRTQPGAAPCKQSFRHAHP 303
            :           .|||:....||      .|..:.||
  Fly   348 L-----------NSVHMGHTQQP------TSLSYLHP 367

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GPER1	NP_001035055.1	7tmA_GPER1	60..335	CDD:320120	55/287 (19%)
		TM helix 1	62..86	CDD:320120	8/33 (24%)
		TM helix 2	95..116	CDD:320120	6/40 (15%)
		TM helix 3	131..153	CDD:320120	2/21 (10%)
		TM helix 4	176..192	CDD:320120	2/15 (13%)
		TM helix 5	212..235	CDD:320120	2/22 (9%)
		TM helix 6	258..280	CDD:320120	2/21 (10%)
		TM helix 7	303..328	CDD:320120	1/1 (100%)
Octbeta3R	NP_001034048.2	7tm_4	146..>346	CDD:304433	41/231 (18%)
Octbeta3R	NP_001034048.2	7tm_1	156..>344	CDD:278431	41/219 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910