DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GPER1 and H09F14.1

DIOPT Version :9

Sequence 1:	NP_001035055.1	Gene:	GPER1 / 2852	HGNCID:	4485	Length:	375	Species:	Homo sapiens
Sequence 2:	NP_001256232.1	Gene:	H09F14.1 / 186709	WormBaseID:	WBGene00010375	Length:	401	Species:	Caenorhabditis elegans

Alignment Length:	380	Identity:	74/380 - (19%)
Similarity:	140/380 - (36%)	Gaps:	84/380 - (22%)

- Green bases have known domain annotations that are detailed below.

Human    54 QYVIGLFLSCLYTIFLFPIGFVGNILILVVNISFREKMTIPDLYFINLAVADLILVADSLIEVFN 118
            |:.:.::|..|..||    |..||::.||.....|.:....::|.|.|.:||.|.:...|:..|.
Worm     7 QFDVYMYLLPLIVIF----GLSGNVISLVTIFHSRLRRVNANIYLIVLTLADSIFLTGILLICFK 67

Human   119 LHERYYDIAVLCTFMSLFLQVNMYSSVFFLTWMSFDRYIALARAMRCSLFRTKHHARLSCGLIWM 183
            :....|:   .|..:...|....|.|.:....::.:||:|:|..:  |..:..|..|....|.|:
Worm    68 VDWIAYE---YCVGLEYVLMTASYISSWSTAALTIERYLAIAHPL--SHMKYGHVDRAKVMLYWV 127

Human   184 ASVSATLVPFTAVHLQH------TDEACFCFADVRE---VQWLEVTLGFIVPFAIIGLCYSLIVR 239
            .      :||.....|.      |:|......:...   .|.::..|.::||..||.:...|:..
Worm   128 P------IPFVLQLFQFFSLEPATEERKCALKEANYQIIAQAVDTVLCYVVPCGIIVVLNILVAL 186

Human   240 VLVRAHRHRGLRPRRQKALR---------------MILAVVLV-----FFVCWLPENVFISVHLL 284
            .:.::..|.....::..:.|               .::.:|.|     |:|..:.|.||   .::
Worm   187 QVQKSQEHFMAETKKSNSRRTGGSSSSSGTWTRILWVMPLVFVVLNTPFYVIMMIEIVF---QII 248

Human   285 QRTQPGAAPCKQSFRHAHPLTGHIVNLAAFSNSCLNPLIYSFLGETFRDKLRL---------YIE 340
            .::.|......:.|...:. |.|.:   .:.|:.::.|:|:|....||....:         |.|
Worm   249 YQSPPSGDTRSELFVTVYN-TAHYM---YYMNTAIDVLVYAFSSANFRKTAVIAWKRILCPGYAE 309

Human   341 QKTNLPALNRFCHAALKAV---------------IPDST---------EQSDVRF 371
            ::.....|....|:...::               :.|.|         |:|.:||
Worm   310 RQKGKRFLLSMVHSVSDSIRKRIPIAQPAPHTVLVTDQTSRISYRMTSERSTIRF 364

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GPER1	NP_001035055.1	7tmA_GPER1	60..335	CDD:320120	63/303 (21%)
		TM helix 1	62..86	CDD:320120	8/23 (35%)
		TM helix 2	95..116	CDD:320120	7/20 (35%)
		TM helix 3	131..153	CDD:320120	3/21 (14%)
		TM helix 4	176..192	CDD:320120	2/15 (13%)
		TM helix 5	212..235	CDD:320120	6/25 (24%)
		TM helix 6	258..280	CDD:320120	8/41 (20%)
		TM helix 7	303..328	CDD:320120	6/24 (25%)
H09F14.1	NP_001256232.1	7tm_GPCRs	10..295	CDD:391938	63/306 (21%)
		TM helix 1	10..36	CDD:341315	9/29 (31%)
		TM helix 2	43..67	CDD:341315	7/23 (30%)
		TM helix 3	77..106	CDD:341315	6/28 (21%)
		TM helix 5	158..183	CDD:341315	6/24 (25%)
		TM helix 6	212..242	CDD:341315	4/29 (14%)
		TM helix 7	263..288	CDD:341315	6/28 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910