DRSC/TRiP Functional Genomics Resources

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Protein Alignment GPER1 and ser-7

DIOPT Version :9

Sequence 1:NP_001035055.1 Gene:GPER1 / 2852 HGNCID:4485 Length:375 Species:Homo sapiens
Sequence 2:NP_741730.1 Gene:ser-7 / 180565 WormBaseID:WBGene00004780 Length:435 Species:Caenorhabditis elegans


Alignment Length:363 Identity:70/363 - (19%)
Similarity:127/363 - (34%) Gaps:97/363 - (26%)


- Green bases have known domain annotations that are detailed below.


Human    55 YVIGLFLSCLYTIFLFPIGFVGNILILVVNISFREKMTIPDLYFINLAVAD----LILVADSLIE 115
            :..|..|..:..:.:..:..|||.|:.:..:..|:.....:...::|||||    |:::..:||:
 Worm    37 FTTGKALLAIAILAMIIMTTVGNALVCLAVLLVRKLKHPQNFLLVSLAVADFFVGLVVMPLALID 101

Human   116 VFNLHERYYDIAVLCTFMSLFLQVNMYSSVFFLTWMSFDRYIALARAMRCSLFRTKHHARLSCGL 180
            :  |.:::...:.:|:..:........:|:..|..:|.|||:.::..:|.|..||.....:....
 Worm   102 L--LFDKWPLGSTMCSVYTTSDLTLCTASIVNLCAISVDRYLVISSPLRYSAKRTTKRIMMYIAC 164

Human   181 IW----MASVSATLVPFTAVHLQHTDEACFCFADVREV-QWLEVTLGFIVPFAIIGLCYSLIVRV 240
            :|    :.|:|:.::........:.|:...|......: |.....:.|..|..|:.:....|.|.
 Worm   165 VWIIAAIVSISSHIIANLLNDGTYVDDTGTCQVIPHFIYQSYATIISFYAPTFIMVILNIKIWRA 229

Human   241 LVRAHRHRGL-----------RPR----------------------------------------- 253
            ..|......|           |||                                         
 Worm   230 AKRLAAQDRLMSHCNSVDASERPRNGSAETKDFLNEKETIDVPKKERANSTNSRLFKLERKYLHR 294

Human   254 -------------RQ------KALRMILAVVLVFFVCWLPENVFISVHLLQRTQPGAAPCKQSFR 299
                         ||      ||.:.:..::.||.:||||   |..:.:.           :||.
 Worm   295 PSAFFSAAKGPLIRQTEKSECKARKTLGVIMSVFIICWLP---FFILAIF-----------KSFG 345

Human   300 HAHPLTGHIVNL-AAFSNSCLNPLIYSFLGETFRDKLR 336
            ...|....::.| ..:|||.||||||....:.||...|
 Worm   346 MWIPDWLDLLALWLGYSNSTLNPLIYCKYNKEFRIPFR 383

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GPER1NP_001035055.1 7tmA_GPER1 60..335 CDD:320120 68/355 (19%)
TM helix 1 62..86 CDD:320120 4/23 (17%)
TM helix 2 95..116 CDD:320120 8/24 (33%)
TM helix 3 131..153 CDD:320120 2/21 (10%)
TM helix 4 176..192 CDD:320120 3/19 (16%)
TM helix 5 212..235 CDD:320120 4/23 (17%)
TM helix 6 258..280 CDD:320120 7/21 (33%)
TM helix 7 303..328 CDD:320120 11/25 (44%)
ser-7NP_741730.1 7tmA_5-HT7 42..382 CDD:320452 68/355 (19%)
TM helix 1 44..68 CDD:320452 4/23 (17%)
TM helix 2 77..99 CDD:320452 6/21 (29%)
TM helix 3 115..137 CDD:320452 2/21 (10%)
TM helix 4 160..176 CDD:320452 2/15 (13%)
TM helix 5 201..224 CDD:320452 4/22 (18%)
TM helix 6 315..340 CDD:320452 9/27 (33%)
TM helix 7 350..375 CDD:320452 10/24 (42%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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