DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GPER1 and npr-25

DIOPT Version :9

Sequence 1:	NP_001035055.1	Gene:	GPER1 / 2852	HGNCID:	4485	Length:	375	Species:	Homo sapiens
Sequence 2:	NP_505883.1	Gene:	npr-25 / 179570	WormBaseID:	WBGene00011381	Length:	376	Species:	Caenorhabditis elegans

Alignment Length:	397	Identity:	83/397 - (20%)
Similarity:	144/397 - (36%)	Gaps:	100/397 - (25%)

- Green bases have known domain annotations that are detailed below.

Human    36 PLLGTALANGTGELSEHQQYVIGLFLSCLYTIFLFPIGFVGNILIL----VVNISFREKMTI--- 93
            ||:|.:.|.                .:..|:| .|..|.:||..:|    .:..|.:..:|.
Worm    14 PLVGASFAK----------------TAIPYSI-CFVFGTLGNTAVLSYVFFITRSLKSSVTALGN 61

Human    94 PDLYFINLAVADLILVADSLIEV-FNLHERYYDIAVLCTFMSLFLQVNMYSSVFFLTWMSFDRYI 157
            ..:|.:.|...||::.......: :.:...:....::|....:....|...|.|.||.::||||:
Worm    62 TFIYIVALCAVDLLVTVSIPFSLSYMILNNWVFGELVCKIHFMLELSNKMCSTFILTALAFDRYM 126

Human   158 ALA-------RAMRCSLFRTKHHARLSCGLIWMASVSATLVPF-------TAVHLQHTDEACFCF 208
            |:.       ..||.:::.|...|.||..||....:||.:..|       :|.:.:|......|.
Worm   127 AICHPEIKRIHEMRHTIYITTILATLSLFLISPVVLSARVTSFKSGQYFVSAKNERHEVIRQMCI 191

Human   209 ADVREVQWLEVTLGFIVPFAIIGLCYSL---IVRVLVRAHRHRGLRPRRQKALRMI----LAVVL 266
             |...::|......|::.||.:..|..|   ..::::|..|.|....:.:..||.|    :|...
Worm   192 -DGMALEWKVWVSAFLIFFAFLLPCTLLTYFYAKIVLRLRRQRRTMLQSRIPLRRITIYTMAATF 255

Human   267 VFFVC----WLPE--NVFISVHLLQRTQPGAAPCKQSFRHAHPLTGHIVN-----------LAAF 314
            .:..|    |||:  |:|.:|                       .||.:|           |..|
Worm   256 FYLSCHIPFWLPQIYNIFSTV-----------------------LGHKMNPKVMTFTYYSHLLPF 297

Human   315 SNSCLNPLIYSFLGETFRDKLRL----YIEQKTNLPALNRFCHAALK---------AVIPDSTEQ 366
            .::..|.:.|:.|...|:..|.|    .|.::|.......:..||::         .:.|....|
Worm   298 ISAAFNWIFYARLNSQFKKGLVLVTERMIRKRTKSMHEKGYSEAAVELTSKFDDVPLMCPHCEAQ 362

Human   367 SDVRFSS 373
            ..:|.||
Worm   363 LSIRSSS 369

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GPER1	NP_001035055.1	7tmA_GPER1	60..335	CDD:320120	68/320 (21%)
		TM helix 1	62..86	CDD:320120	7/27 (26%)
		TM helix 2	95..116	CDD:320120	4/20 (20%)
		TM helix 3	131..153	CDD:320120	5/21 (24%)
		TM helix 4	176..192	CDD:320120	6/15 (40%)
		TM helix 5	212..235	CDD:320120	5/22 (23%)
		TM helix 6	258..280	CDD:320120	10/31 (32%)
		TM helix 7	303..328	CDD:320120	7/35 (20%)
npr-25	NP_505883.1	7tm_classA_rhodopsin-like	24..311	CDD:381740	66/311 (21%)
		TM helix 1	24..48	CDD:381740	7/24 (29%)
		TM helix 2	63..84	CDD:381740	4/20 (20%)
		TM helix 3	100..122	CDD:381740	5/21 (24%)
		TM helix 4	144..160	CDD:381740	6/15 (40%)
		TM helix 5	200..223	CDD:381740	5/22 (23%)
		TM helix 6	244..269	CDD:381740	7/24 (29%)
		TM helix 7	286..311	CDD:381740	4/24 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910