DRSC/TRiP Functional Genomics Resources

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Protein Alignment GPER1 and dop-2

DIOPT Version :9

Sequence 1:NP_001035055.1 Gene:GPER1 / 2852 HGNCID:4485 Length:375 Species:Homo sapiens
Sequence 2:NP_001256126.1 Gene:dop-2 / 179347 WormBaseID:WBGene00001053 Length:849 Species:Caenorhabditis elegans


Alignment Length:264 Identity:56/264 - (21%)
Similarity:114/264 - (43%) Gaps:52/264 - (19%)


- Green bases have known domain annotations that are detailed below.


Human    10 VGLEMYPGTAQPAAPNTTSPELNLSHPLLGTALANGTGELSEHQQYVIGLFLSCLY---TIFLFP 71
            |.||..|            |.|:||             .:::....::|..:...|   ::.:.|
 Worm     9 VSLEWPP------------PSLDLS-------------TITQTPSTIVGSGIPLNYAGLSLIVIP 48

Human    72 -IGFVGNILILVVNISFREKMTIPDLYFINLAVADL---ILVADSLIEVFNLHERYYDIAVLCTF 132
             |..:||:|:::..:.:|...:..:...:.||||||   |:|....:.|:..:..:|...::|  
 Worm    49 LITLLGNLLVIISVLRYRALQSAINFLILGLAVADLLVAIIVMPYAVYVYVTNGDWYLGNLMC-- 111

Human   133 MSLFLQVNM---YSSVFFLTWMSFDRYIALARAMRCSLFRTKHHAR---LSCGLIWMASVSATLV 191
             .:::..::   .:|:..|..:|||||.|::..::.|  |...:.:   ....:||:.|::....
 Worm   112 -DIYMASDVCCSTASILLLAVISFDRYRAVSLPIQYS--RQSQNVKRVWTLIAVIWLVSLTLASP 173

Human   192 PFTAVHLQHTD----EACFCFADVREVQWLEVTLGFIVPFAIIGLCYSLIVRVLVRAHRHRGLRP 252
            ....|:::..|    |..|..|   |...|...:.|::|..::...|..|:..|.:  |.:..:.
 Worm   174 MVFGVNVRPPDANPYECRFYNA---EFSILSSMISFVIPCFLVLFVYIRIIIALKK--REKAAKM 233

Human   253 RRQK 256
            ||:|
 Worm   234 RREK 237

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GPER1NP_001035055.1 7tmA_GPER1 60..335 CDD:320120 47/214 (22%)
TM helix 1 62..86 CDD:320120 6/27 (22%)
TM helix 2 95..116 CDD:320120 8/23 (35%)
TM helix 3 131..153 CDD:320120 2/24 (8%)
TM helix 4 176..192 CDD:320120 3/15 (20%)
TM helix 5 212..235 CDD:320120 4/22 (18%)
TM helix 6 258..280 CDD:320120
TM helix 7 303..328 CDD:320120
dop-2NP_001256126.1 7tmA_D2-like_dopamine_R 38..>233 CDD:320181 44/204 (22%)
TM helix 1 40..64 CDD:320181 5/23 (22%)
TM helix 2 73..95 CDD:320181 8/21 (38%)
TM helix 3 112..134 CDD:320181 2/21 (10%)
TM helix 4 158..174 CDD:320181 3/15 (20%)
TM helix 5 195..218 CDD:320181 5/25 (20%)
7tm_GPCRs <745..828 CDD:421689
TM helix 6 751..781 CDD:410628
TM helix 7 796..821 CDD:410628
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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