DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GPER1 and dmsr-7

DIOPT Version :9

Sequence 1:	NP_001035055.1	Gene:	GPER1 / 2852	HGNCID:	4485	Length:	375	Species:	Homo sapiens
Sequence 2:	NP_504431.2	Gene:	dmsr-7 / 178922	WormBaseID:	WBGene00016428	Length:	429	Species:	Caenorhabditis elegans

Alignment Length:	397	Identity:	80/397 - (20%)
Similarity:	142/397 - (35%)	Gaps:	127/397 - (31%)

- Green bases have known domain annotations that are detailed below.

Human    16 PGTAQPAAPNTTSPEL---NLSH------PLLGTALANGTGELSEHQQYVIGLFLSCLYTIFLFP 71
            |..||...||:.|.:.   .|:|      |:.|               ||  ..|.|::.||
Worm     4 PHDAQLFDPNSNSTQAFLRKLAHFQRWYQPIHG---------------YV--CVLICVFGIF--- 48

Human    72 IGFVGNILILVVNISFREKMTIPDLYFINLAVADLILVADSLIEVFNLHERYYDIAVLCTFMSLF 136
            ..||...::...|:    :.:..:.....:||.|:..:|..||.:.:...|..: :...||...:
Worm    49 TNFVHVAVLSRPNM----RNSAVNCILTAVAVCDIGTMASYLIYIIHFVLRRNN-SCTPTFTHSW 108

Human   137 LQVNMYSSVFFLT------W----MSFDRYIAL-ARAMRCSLFRTKHHARLSCGLIWMASVSATL 190
            ||..::..|..:|      |    |:|.|.:.| ..|:.....|.|...:|..| |:|. |....
Worm   109 LQFLLWHVVLSITLHTTSLWLAVAMAFIRRMTLRVTALNSQWQRPKFAWKLCLG-IYMV-VFVLC 171

Human   191 VPFTAVH----LQHTD----EACFCFADVREVQWLEVTLGFIVPFA--------------IIGLC 233
            :|...||    ::..|    :.|..||.    .:.|....|:|..|              :||:.
Worm   172 IPNMLVHEIARVEGNDWRPGKTCQKFAS----NYSEPVYTFMVSHAATINNCRLFKWNIWMIGIL 232

Human   234 YSLIVRVLV------------RAHRHR------------GLRPRRQK------ALRMILAVVLVF 268
            :.:|..:|:            .|.:||            ..:|.::|      ...|::.::|||
Worm   233 FKIIPCILLIFLSFGLVSKIRDAEKHRRKLTSVPSNASTDSKPLKKKNGTSDRTTLMLVVILLVF 297

Human   269 FVCWLPENVF--------ISVHLLQRTQPGAAPCKQSFRHAHPLTGHIVNLAAFSNSCLNPLIYS 325
            .:...|:.:.        ..||                |:.:...|.:::|.:..||.:|.::|.
Worm   298 LITEFPQGIISILCAIFTTDVH----------------RYLYFYIGDVLDLLSLVNSSVNFVLYC 346

Human   326 FLGETFR 332
            .:...:|
Worm   347 VMSSRYR 353

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GPER1	NP_001035055.1	7tmA_GPER1	60..335	CDD:320120	68/344 (20%)
		TM helix 1	62..86	CDD:320120	6/23 (26%)
		TM helix 2	95..116	CDD:320120	6/20 (30%)
		TM helix 3	131..153	CDD:320120	8/31 (26%)
		TM helix 4	176..192	CDD:320120	5/15 (33%)
		TM helix 5	212..235	CDD:320120	6/36 (17%)
		TM helix 6	258..280	CDD:320120	5/29 (17%)
		TM helix 7	303..328	CDD:320120	6/24 (25%)
dmsr-7	NP_504431.2	7tmA_FMRFamide_R-like	33..356	CDD:320109	72/368 (20%)
		TM helix 1	35..59	CDD:320109	9/43 (21%)
		TM helix 2	68..90	CDD:320109	6/21 (29%)
		TM helix 3	113..135	CDD:320109	4/21 (19%)
		TM helix 4	158..174	CDD:320109	5/17 (29%)
		TM helix 5	223..246	CDD:320109	4/22 (18%)
		TM helix 6	284..309	CDD:320109	5/24 (21%)
		TM helix 7	324..349	CDD:320109	6/24 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910