Protein Alignment GPER1 and ckr-2

DIOPT Version :9

• Sequence 1: NP_001035055.1
• Gene: GPER1 / 2852
• HGNCID: 4485
• Length: 375
• Species: Homo sapiens
• Sequence 2: NP_001367973.1
• Gene: ckr-2 / 175341
• WormBaseID: WBGene00021439
• Length: 603
• Species: Caenorhabditis elegans
• Alignment Length: 542
• Identity: 98/542 - (18%)
• Similarity: 169/542 - (31%)
• Gaps: 243/542 - (44%)

Human    25 NTTSPELNLSHPLLGTALANGTGELSEHQQYVIGLFLSCL--YTI-----FLFPIGFVGNILILV 82
            |.|||      |.:.|..:|.:..:|...|..|..|....  |||     .:|.:..|||.::|:
 Worm    25 NATSP------PPIWTLNSNLSTTMSTVHQEEICRFRGTTENYTIAVTFFMIFLLSVVGNSVVLI 83

Human    83 VNISFREKMTIPDLYFINLAVADLIL----VADSLIE-VFN--LHERYYDIAVLCTFMSLFLQVN 140
            |.|..|...:|.::|.:|||.:|::|    :..:|:. |.|  :...|     :|..::....|.
 Worm    84 VIIKQRAMRSITNIYLMNLAASDMMLSVVCMPPTLVSMVMNCWMFGNY-----MCKILAYLQPVV 143

Human   141 MYSSVFFLTWMSFDRYIALARAMRCSLFRTKHHARLSCGLIWMASVSATL--------------- 190
            :.:|.:.|..::|:||.|:.:.:...:::|:.||.....|:|:.:::|.:
 Worm   144 VTASAYTLAVIAFERYFAICKPLHSRIWQTRSHAYAMITLVWVIAIAANILMLFMYEQQTYSSNG 208

Human   191 ----------------VPFTAVHL----------------------------------------- 198
                            |..|.|.|
 Worm   209 YTCAPIHPPIYHFAYQVYMTVVLLVIPLVVMAGLYGNVITSLKSGIKLEIASVDPPLATATTTGA 273

Human   199 ----QHTDEA-------------------CF---------------------------------- 206
                .|:|.|                   |.
 Worm   274 KNLGSHSDSAHLLLNNVLVGSSQLARATSCIALNTFSCNNTTNPFSTLTPPPPIQQKNRSKPQLL 338

Human   207 ---------------CFADVREVQWLEVTLGFIVPFAIIG-----------------LCYSLIVR 239
                           |.:|.|....|      ..|.||:.                 |.:|...:
 Worm   339 QLPGKIDNFEEFRLQCLSDCRSDGVL------FPPPAIVASMTDEQKLSFWNKLSNKLTFSQQDK 397

Human   240 VLVR---AHR---------HRGLRP--------RRQKALRMILAVVLVFFVCWLPENV------- 277
            .:..   .||         :..||.        .:|:.::|::.||::||.||.|..:
 Worm   398 TVQHPNFGHRKSDTSICLENPSLRSTHTQKSAMAKQRVIKMLIVVVIIFFCCWTPSYIWWLLLIA 462

Human   278 ---FISVHLLQRTQPGAAPCKQSFRHAHPLTGHIVNLAAFSNSCLNPLIYSFLGETFRDKLRLYI 339
               |.|::|             |..::...|  .:.|..:.:||.||:.|.||.:.||:.:....
 Worm   463 GDSFQSLNL-------------SVWNSDINT--FITLLTYISSCTNPITYCFLNKKFRNAVYATF 512

Human   340 EQKTNLPALNRFCHAALKAVIP 361
            .:|.|:.      |...|..||
 Worm   513 GRKKNMR------HHFQKVYIP 528

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GPER1	NP_001035055.1	7tmA_GPER1	60..335	CDD:320120	82/479 (17%)
		TM helix 1	62..86	CDD:320120	9/30 (30%)
		TM helix 2	95..116	CDD:320120	7/25 (28%)
		TM helix 3	131..153	CDD:320120	3/21 (14%)
		TM helix 4	176..192	CDD:320120	3/46 (7%)
		TM helix 5	212..235	CDD:320120	6/39 (15%)
		TM helix 6	258..280	CDD:320120	9/31 (29%)
		TM helix 7	303..328	CDD:320120	8/24 (33%)
ckr-2	NP_001367973.1	7tmA_CCKR-like	61..508	CDD:320124	81/472 (17%)
		TM helix 1	63..87	CDD:320124	7/23 (30%)
		TM helix 2	96..118	CDD:320124	6/21 (29%)
		TM helix 3	134..156	CDD:320124	3/21 (14%)
		TM helix 4	179..195	CDD:320124	3/15 (20%)
		TM helix 5	221..244	CDD:320124	4/22 (18%)
		TM helix 6	436..458	CDD:320124	8/21 (38%)
		TM helix 7	476..501	CDD:320124	8/26 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910