DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GPER1 and npr-34

DIOPT Version :9

Sequence 1:	NP_001035055.1	Gene:	GPER1 / 2852	HGNCID:	4485	Length:	375	Species:	Homo sapiens
Sequence 2:	NP_497057.2	Gene:	npr-34 / 175131	WormBaseID:	WBGene00013187	Length:	613	Species:	Caenorhabditis elegans

Alignment Length:	441	Identity:	86/441 - (19%)
Similarity:	167/441 - (37%)	Gaps:	139/441 - (31%)

- Green bases have known domain annotations that are detailed below.

Human    25 NTTSPELNLSHPL---LGTALANGT-------GELSEHQQYVIGLFLSCLYTIFLFPIGFVGNIL 79
            |.|:.:.|.:|||   |...::..|       ..:::.:.:.|.|......|:||  :|.:||.:
Worm    30 NMTAMDCNCTHPLHKYLEVCISRCTVPDDTVFFSMTDEELFEIALPGFLYLTVFL--VGTIGNSM 92

Human    80 ILVVNISFREKMTIPDLYFINLAVADLILVADSLIEVFNLHERYYDIAVL--------------- 129
            ::.|...|:....:.:::..:|:.|||.|:             ::.:.::
Worm    93 VIFVVNRFKRMRNVTNIFLASLSTADLCLI-------------WFCVPIMFMKYMSHTWSMGRFA 144

Human   130 CTFMSLFLQVNMYSSVFFLTWMSFDRYIALARAMRCSLFRTKHHARLSCGLIWMASVSATLVPFT 194
            |..:....|...:.||..:|.:||:|::|:|..||...|.:...|:....||||:  ||.|...|
Worm   145 CYSVHYIQQFTCFCSVLTMTMISFERFLAIAYPMRNIWFSSIGRAKKVILLIWMS--SAVLAVPT 207

Human   195 AVHLQHTDEACFCFADVREVQW-----------------------LEVTLGFIVPFAIIGLCYSL 236
            ||.:.:  |.....:..| |.|                       .::.|..|.|...:.:||:.
Worm   208 AVRMDY--ETNLSLSGQR-VHWCRRRFPAQFLGYPRTSLNKAYAMYQLLLLIIFPVLTMSICYAR 269

Human   237 IVRVLVRAHR-------------------------------------------------HRGLR- 251
            :..::.::.:                                                 ||..|
Worm   270 VSAIVYKSSKDRVILSQAMVAFSKAATDAVTFSGYSAIPMITTSRNLKTANTTIKSYSNHRNNRV 334

Human   252 --PRRQKALRMILAVVLVFFVCWLP---ENVFISVHLLQRTQPGAAPCKQSFRHAHPLTGHIVNL 311
              ..:::.::|::::|.::.|||||   :.:..|...:.||..     .|:.:|..  .|  .|.
Worm   335 AEANKKQIVQMLISIVCMYTVCWLPTIVDELLTSFGYICRTSN-----TQTLKHMR--MG--FNA 390

Human   312 AAFSNSCLNPLIYSFLGETFRDKLR-LYIEQKTNLPALNRF------CHAA 355
            ..:..||:||::|:|:.:.||...: .|...|:.|..:...      |.:|
Worm   391 LTYCQSCINPILYAFISQNFRSTFKTAYSRMKSRLQGVEEMRSRMGSCSSA 441

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GPER1	NP_001035055.1	7tmA_GPER1	60..335	CDD:320120	71/367 (19%)
		TM helix 1	62..86	CDD:320120	7/23 (30%)
		TM helix 2	95..116	CDD:320120	5/20 (25%)
		TM helix 3	131..153	CDD:320120	4/21 (19%)
		TM helix 4	176..192	CDD:320120	7/15 (47%)
		TM helix 5	212..235	CDD:320120	7/45 (16%)
		TM helix 6	258..280	CDD:320120	7/24 (29%)
		TM helix 7	303..328	CDD:320120	8/24 (33%)
npr-34	NP_497057.2	7tmA_GPRnna14-like	75..414	CDD:320132	71/367 (19%)
		TM helix 1	75..99	CDD:320132	7/25 (28%)
		TM helix 2	108..130	CDD:320132	5/34 (15%)
		TM helix 3	146..168	CDD:320132	4/21 (19%)
		TM helix 4	191..207	CDD:320132	7/17 (41%)
		TM helix 5	245..268	CDD:320132	4/22 (18%)
		TM helix 6	340..365	CDD:320132	7/24 (29%)
		TM helix 7	382..407	CDD:320132	9/28 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910