DRSC/TRiP Functional Genomics Resources

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Protein Alignment GPER1 and nmur-2

DIOPT Version :9

Sequence 1:NP_001035055.1 Gene:GPER1 / 2852 HGNCID:4485 Length:375 Species:Homo sapiens
Sequence 2:NP_493666.2 Gene:nmur-2 / 173398 WormBaseID:WBGene00019616 Length:403 Species:Caenorhabditis elegans


Alignment Length:378 Identity:85/378 - (22%)
Similarity:162/378 - (42%) Gaps:77/378 - (20%)


- Green bases have known domain annotations that are detailed below.


Human    49 LSEHQQYVI----------GLFLSCLY---TIFLFPIGFVGNILILVVNISFREKMTIPDLYFI- 99
            :||..:||:          |:.:..:.   ||||  :|..|||...:| |:..:.|..|..|:: 
 Worm    10 VSEITEYVLSTLGERCQSAGIVIPTVIIYGTIFL--LGLFGNICTCIV-IAANKSMHNPTNYYLF 71

Human   100 NLAVADLI-LVADSLIEVFNLHERYYDIAV---LCTFMSLFLQVNMYSSVFFLTWMSFDRYIALA 160
            :|||:|:| |:....:|.:...:..|....   :|...:..::...|:|:..:...||:|::|:.
 Worm    72 SLAVSDIIALILGLPMEFYQSLDYSYPYRFSEGICKARAFLIEFTSYASIMIICCFSFERWLAIC 136

Human   161 RAMRCSLFRTKHHARLSCGLIWMASV-------------------SATLVPFT------AVHLQH 200
            ..:|..:|.|...|.:...|.|..|.                   .|...|:|      .:.:.|
 Worm   137 HPLRSKIFSTLWRANVLIILAWTISFVCALPIAFIVQINKLPLPEDAKYQPWTNKVSTDGIFVLH 201

Human   201 TDEACFCFAD------VREVQWLEVTLGFIVPFAIIGLCYSLIVRVL----VRAHRHRGLRPRRQ 255
            |:   ||..:      .:.:.....|:.|::|...|.:.|:.|...|    :.....:.::.||.
 Worm   202 TE---FCAMNQSRPDQQKMIIIFAFTVFFVIPAIAIVIMYAHIAVQLESSEIDLKGDKMVKKRRN 263

Human   256 KA----LRMILAVVLVFFVCWLPENV--FISVHLLQRTQPGAAPCKQSFRHAHPLTGHIVNLAAF 314
            |:    |:|:|:||:.||:||||.::  .:||:.........:|..|   ....:..:|.....:
 Worm   264 KSNRTVLKMLLSVVITFFICWLPFHIQRLLSVYTTWSETTTISPPVQ---FLSMIVFYISGFCYY 325

Human   315 SNSCLNPLIYSFLGETFR---------DKLRLYIEQKTNLPALNRFCHAALKA 358
            |||..||::|:.|.:.:|         |.:..::.:....|..::.|.::.:|
 Worm   326 SNSAANPILYNILSQKYRSAFCRTILGDHIANFVFKGHQRPGQSKRCSSSTEA 378

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GPER1NP_001035055.1 7tmA_GPER1 60..335 CDD:320120 77/332 (23%)
TM helix 1 62..86 CDD:320120 9/26 (35%)
TM helix 2 95..116 CDD:320120 7/22 (32%)
TM helix 3 131..153 CDD:320120 2/21 (10%)
TM helix 4 176..192 CDD:320120 4/34 (12%)
TM helix 5 212..235 CDD:320120 4/22 (18%)
TM helix 6 258..280 CDD:320120 11/23 (48%)
TM helix 7 303..328 CDD:320120 7/24 (29%)
nmur-2NP_493666.2 7tmA_capaR 32..346 CDD:320262 76/322 (24%)
TM helix 1 34..58 CDD:320262 10/26 (38%)
TM helix 2 67..89 CDD:320262 7/21 (33%)
TM helix 3 107..129 CDD:320262 2/21 (10%)
TM helix 4 152..168 CDD:320262 3/15 (20%)
TM helix 5 216..239 CDD:320262 4/22 (18%)
TM helix 6 267..292 CDD:320262 11/24 (46%)
TM helix 7 314..339 CDD:320262 7/24 (29%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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