DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GPER1 and gper1

DIOPT Version :9

Sequence 1:	NP_001035055.1	Gene:	GPER1 / 2852	HGNCID:	4485	Length:	375	Species:	Homo sapiens
Sequence 2:	NP_001107725.1	Gene:	gper1 / 100135723	XenbaseID:	XB-GENE-1006475	Length:	361	Species:	Xenopus tropicalis

Alignment Length:	375	Identity:	258/375 - (68%)
Similarity:	309/375 - (82%)	Gaps:	14/375 - (3%)

- Green bases have known domain annotations that are detailed below.

Human     1 MDVTSQARGVGLEMYPGTAQPAAPNTTSPELNLSHPLLGTALANGTGELSEHQQYVIGLFLSCLY 65
            ||:.:    :|||       ....|.|..|:|.|:....:...:|..|::.|  |:|||.|||||
Frog     1 MDIYN----IGLE-------TIICNVTFLEMNGSNICNESLAEDGISEVNRH--YLIGLVLSCLY 52

Human    66 TIFLFPIGFVGNILILVVNISFREKMTIPDLYFINLAVADLILVADSLIEVFNLHERYYDIAVLC 130
            ||.||||||:|||:|||||||||||||||||||||||.||||||||||||||||:|:||||.:||
Frog    53 TILLFPIGFIGNIMILVVNISFREKMTIPDLYFINLAAADLILVADSLIEVFNLNEKYYDITILC 117

Human   131 TFMSLFLQVNMYSSVFFLTWMSFDRYIALARAMRCSLFRTKHHARLSCGLIWMASVSATLVPFTA 195
            ||||||||:|||||:|||||||||||||||:.|:.::||||.|||||||||||||:||||:||||
Frog   118 TFMSLFLQINMYSSIFFLTWMSFDRYIALAKVMKSNIFRTKMHARLSCGLIWMASISATLLPFTA 182

Human   196 VHLQHTDEACFCFADVREVQWLEVTLGFIVPFAIIGLCYSLIVRVLVRAHRHRGLRPRRQKALRM 260
            |.:|||.:..||||||:|:||||:|||||:||||||||||||.|||:|||:||.:||||||||||
Frog   183 VQVQHTGDMHFCFADVKEIQWLEITLGFIIPFAIIGLCYSLIFRVLIRAHKHRCMRPRRQKALRM 247

Human   261 ILAVVLVFFVCWLPENVFISVHLLQRTQPGAAPCKQSFRHAHPLTGHIVNLAAFSNSCLNPLIYS 325
            |:.||||||:||||||||||:.||| ::.......:||||.||||||||||||||||||||||||
Frog   248 IVIVVLVFFICWLPENVFISISLLQ-SEDEEQSYNRSFRHNHPLTGHIVNLAAFSNSCLNPLIYS 311

Human   326 FLGETFRDKLRLYIEQKTNLPALNRFCHAALKAVIPDSTEQSDVRFSSAV 375
            ||||||||||||||:.|.::.|.||||..::|:|||:|::.|:.::.:.|
Frog   312 FLGETFRDKLRLYIKGKKSMAAFNRFCQTSVKSVIPESSDHSEAKYITGV 361

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GPER1	NP_001035055.1	7tmA_GPER1	60..335	CDD:320120	222/274 (81%)
		TM helix 1	62..86	CDD:320120	20/23 (87%)
		TM helix 2	95..116	CDD:320120	19/20 (95%)
		TM helix 3	131..153	CDD:320120	19/21 (90%)
		TM helix 4	176..192	CDD:320120	14/15 (93%)
		TM helix 5	212..235	CDD:320120	18/22 (82%)
		TM helix 6	258..280	CDD:320120	18/21 (86%)
		TM helix 7	303..328	CDD:320120	24/24 (100%)
gper1	NP_001107725.1	7tmA_GPER1	47..321	CDD:320120	222/274 (81%)
		TM helix 1	48..74	CDD:320120	22/25 (88%)
		TM helix 2	81..106	CDD:320120	23/24 (96%)
		TM helix 3	117..147	CDD:320120	27/29 (93%)
		TM helix 4	160..181	CDD:320120	18/20 (90%)
		TM helix 5	198..225	CDD:320120	22/26 (85%)
		TM helix 6	239..269	CDD:320120	26/29 (90%)
		TM helix 7	289..314	CDD:320120	24/24 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	416	1.000	Domainoid score	I5527
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H15855
Inparanoid	1	1.050	520	1.000	Inparanoid score	I7434
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG39799
OrthoDB	1	1.010	-	-		D167036at32523
OrthoFinder	1	1.000	-	-		FOG0012406
OrthoInspector	1	1.000	-	-		oto151452
Panther	1	1.100	-	-	LDO	PTHR24226
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X10370
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.080