Protein Alignment SLC9A9 and slc9a6a

DIOPT Version :10

• Sequence 1: NP_775924.1
• Gene: SLC9A9 / 285195
• HGNCID: 20653
• Length: 645
• Species: Homo sapiens
• Sequence 2: NP_001091726.2
• Gene: slc9a6a / 792983
• ZFINID: ZDB-GENE-070424-104
• Length: 697
• Species: Danio rerio
• Alignment Length: 642
• Identity: 378/642 - (58%)
• Similarity: 474/642 - (73%)
• Gaps: 27/642 - (4%)

Human     7 VMSEKDEYQFQHQGAVELLVFNFLLILTILTIWLFKNHRFRFLHETGGAMVYGLIMGLILRYAT- 70
            :::||...:...|.:.:||:|..||.||||||||||:.|||||||||.||:|||::|::||||.
Zfish    45 IVTEKKAEESHRQDSADLLIFIMLLTLTILTIWLFKHRRFRFLHETGLAMIYGLLVGVVLRYAIH 109

Human    71 APTDIESGTVYDCVKLTFSPSTLLVNITDQVYEYKYKREISQHNINPHQGNAILEKMTFDPEIFF 135
            .|:||.:.|: .| .:..||:|||||::.:.|||..|.||..:.:|..|.|.:|.|:|||||:||
Zfish   110 VPSDINNVTL-SC-HVNASPATLLVNVSGKFYEYTLKGEIGANKVNDIQDNEMLRKVTFDPEVFF 172

Human   136 NVLLPPIIFHAGYSLKKRHFFQNLGSILTYAFLGTAISCIVIGLIMYGFVKAMIHAGQLKNGDFH 200
            |:||||||||||||||:||||:||||||.|||:||.:||.:||.:|||.|..|...|.|:: ||.
Zfish   173 NILLPPIIFHAGYSLKRRHFFRNLGSILAYAFVGTVVSCFIIGALMYGCVMLMKKIGHLQD-DFF 236

Human   201 FTDCLFFGSLMSATDPVTVLAIFHELHVDPDLYTLLFGESVLNDAVAIVLTYSISIYSPK-ENPN 264
            ||||||||:::||||||||||||:||.||.|||.|||||||||||||:||:.||..|.|. :|.:
Zfish   237 FTDCLFFGAIVSATDPVTVLAIFNELQVDADLYALLFGESVLNDAVAVVLSSSIVAYQPTGDNSH 301

Human   265 AFDAAAFFQSVGNFLGIFAGSFAMGSAYAIITALLTKFTKLCEFPMLETGLFFLLSWSAFLSAEA 329
            .|:|.|..:|.|.|||:|:||||:|.|..|:|||:||||||.:||:|||.||||:|||.||.|||
Zfish   302 TFEAMAMLKSFGIFLGVFSGSFALGVATGIVTALVTKFTKLRDFPLLETALFFLMSWSTFLLAEA 366

Human   330 AGLTGIVAVLFCGVTQAHYTYNNLSSDSKIRTKQLFEFMNFLAENVIFCYMGLALFTFQNHIFNA 394
            .|.||:|||||||:||||||:||||.:|:.|||||||.:||||||.||.||||.|||||||:||.
Zfish   367 CGFTGVVAVLFCGMTQAHYTFNNLSPESQDRTKQLFELLNFLAENFIFSYMGLTLFTFQNHVFNP 431

Human   395 LFILGAFLAIFVARACNIYPLSFLLNLGRKQKIPWNFQHMMMFSGLRGAIAFALAIRNTESQPKQ 459
            :||:.||||:|:.||.|||||||||||||:.||..||||||||:|||||:.|||:||:|.:..:|
Zfish   432 IFIVCAFLAVFLGRAANIYPLSFLLNLGRRNKISSNFQHMMMFAGLRGAMTFALSIRDTATYARQ 496

Human   460 MMFTTTLLLVFFTVWVFGGGTTPMLTWLQIRVGVDLDENLKEDPSSQHQEANNLDKNMTKAESAR 524
            |||:||||:||||||:.|||||.||:..:||||||.|......|       :.:::..||.|||.
Zfish   497 MMFSTTLLVVFFTVWICGGGTTQMLSCQKIRVGVDTDHENSIGP-------DGVERRSTKQESAW 554

Human   525 LFRMWYSFDHKYLKPILTHSGPPLTTTLPEWCGPISRLLTSPQAY---GEQLKEDDVECIVNQDE 586
            |||:||:|||.||||||||||||||.|||..|.|::|.|||||||   || ||..|.:.|:|..:
Zfish   555 LFRIWYNFDHNYLKPILTHSGPPLTATLPACCSPLARCLTSPQAYENEGE-LKNADSDLILNDGD 618

Human   587 LAINYQEQASSPCSPPARLGLDQKASPQTPG-----KENIYEGDLGLGGYELKLEQT 638
            :.:.|.:.|.|..      |....:|....|     .:...:.:|..|.:||.:..|
Zfish   619 ITLTYGDIAVSTD------GTGAHSSGVLMGGAAVNSDEALDRELAFGDHELVIRGT 669

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC9A9	NP_775924.1	Na_H_Exchanger	128..542	CDD:470090	278/414 (67%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	594..622		5/32 (16%)
slc9a6a	NP_001091726.2	Na_H_Exchanger	52..572	CDD:470090	336/529 (64%)