Protein Alignment SLC9A9 and slc9a7

DIOPT Version :10

• Sequence 1: NP_775924.1
• Gene: SLC9A9 / 285195
• HGNCID: 20653
• Length: 645
• Species: Homo sapiens
• Sequence 2: NP_001025248.2
• Gene: slc9a7 / 554532
• ZFINID: ZDB-GENE-050913-8
• Length: 718
• Species: Danio rerio
• Alignment Length: 661
• Identity: 393/661 - (59%)
• Similarity: 485/661 - (73%)
• Gaps: 39/661 - (5%)

Human     9 SEKDEYQFQHQGAVELLVFNFLLILTILTIWLFKNHRFRFLHETGGAMVYGLIMGLILRYATAPT 73
            :||:..:...|.:|.||.|..||.||||||||||:.|.|||||||.||:|||::|:||||....|
Zfish    46 TEKEAEESHRQDSVNLLTFILLLTLTILTIWLFKHRRVRFLHETGLAMIYGLLVGVILRYGIPST 110

Human    74 DIESGTVYDCVKLTFSPSTLLVNITDQVYEYKYKREISQHNINPHQGNAILEKMTFDPEIFFNVL 138
            ...:.|...|:......||:|:|::.:.:||..|.||:...|:..:.|.:|.|:|||||:|||:|
Zfish   111 SYHNKTPPSCMLKEGPVSTVLLNVSGKFFEYTLKGEINLREIHSVEQNDMLRKLTFDPEVFFNIL 175

Human   139 LPPIIFHAGYSLKKRHFFQNLGSILTYAFLGTAISCIVIGLIMYGFVKAMIHAGQLKNGDFHFTD 203
            ||||||||||||||||||:|||||:|||||||||||.|||.:|||.||.|...|||.: .|::||
Zfish   176 LPPIIFHAGYSLKKRHFFRNLGSIITYAFLGTAISCFVIGNLMYGVVKLMQVLGQLTD-KFYYTD 239

Human   204 CLFFGSLMSATDPVTVLAIFHELHVDPDLYTLLFGESVLNDAVAIVLTYSISIYSPK-ENPNAFD 267
            |||||:::||||||||||||:|||.|.|||.|||||||:||||:|||:.||..|.|. .|.:.||
Zfish   240 CLFFGAIISATDPVTVLAIFNELHADGDLYALLFGESVMNDAVSIVLSSSIVAYQPSGANTHTFD 304

Human   268 AAAFFQSVGNFLGIFAGSFAMGSAYAIITALLTKFTKLCEFPMLETGLFFLLSWSAFLSAEAAGL 332
            |:|||:|||.|:|||:||||||:...::|||:||||||..||:|||.||||:|||.||.|||.|.
Zfish   305 ASAFFKSVGVFIGIFSGSFAMGAVTGVVTALVTKFTKLHCFPLLETALFFLMSWSTFLLAEACGF 369

Human   333 TGIVAVLFCGVTQAHYTYNNLSSDSKIRTKQLFEFMNFLAENVIFCYMGLALFTFQNHIFNALFI 397
            ||:|||||||:|||||||||||.:|..|||||||.::|||||.||.||||||||||||:|:.:||
Zfish   370 TGVVAVLFCGITQAHYTYNNLSEESTKRTKQLFEVLHFLAENFIFSYMGLALFTFQNHVFSPIFI 434

Human   398 LGAFLAIFVARACNIYPLSFLLNLGRKQKIPWNFQHMMMFSGLRGAIAFALAIRNTESQPKQMMF 462
            :|||||||:.||.||||||||:||||:.||..||||||||:|||||:|||||||:|.:..:||||
Zfish   435 VGAFLAIFIGRALNIYPLSFLINLGRRHKIRGNFQHMMMFAGLRGAMAFALAIRDTATYARQMMF 499

Human   463 TTTLLLVFFTVWVFGGGTTPMLTWLQI--------------------RVGVDLDENLKEDPSS-- 505
            |||||:||||||||||||||||:||.|                    |||||.|::|:....|
Zfish   500 TTTLLIVFFTVWVFGGGTTPMLSWLHIRVGESSDAEKERMRRLWNYDRVGVDPDQDLQPCGDSFQ 564

Human   506 --QHQEANNLDKNMTKAESARLFRMWYSFDHKYLKPILTHSGPPLTTTLPEWCGPISRLLTSPQA 568
              |...:.:..::.||.|||.|||:||:|||.||||||||||||||:|||..|||::|.||||||
Zfish   565 VLQGDGSQSEGQSKTKQESAWLFRLWYTFDHNYLKPILTHSGPPLTSTLPACCGPLARCLTSPQA 629

Human   569 Y--GEQLKEDDVECIVNQDELAINYQEQ------ASSPCSPPARL---GLDQKASPQTPGKENIY 622
            |  .|.|:::|.:.|:|:.:|.:.|.:.      |||...|....   ||:.|.|..|  .|:..
Zfish   630 YETHEPLRDNDSDLILNEGDLTLTYGDTAITANGASSSSGPEGSAGIWGLNGKRSDST--SEDAL 692

Human   623 EGDLGLGGYEL 633
            |.:|....:||
Zfish   693 ERELDTREHEL 703

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC9A9	NP_775924.1	Na_H_Exchanger	128..542	CDD:470090	296/438 (68%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	594..622		10/36 (28%)
slc9a7	NP_001025248.2	Na_H_Exchanger	80..>532	CDD:470090	303/452 (67%)