DRSC/TRiP Functional Genomics Resources

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Protein Alignment CDH19 and hmr-1

DIOPT Version :10

Sequence 1:NP_066976.1 Gene:CDH19 / 28513 HGNCID:1758 Length:772 Species:Homo sapiens
Sequence 2:NP_001021650.1 Gene:hmr-1 / 173007 WormBaseID:WBGene00001980 Length:2920 Species:Caenorhabditis elegans


Alignment Length:614 Identity:163/614 - (26%)
Similarity:261/614 - (42%) Gaps:119/614 - (19%)


- Green bases have known domain annotations that are detailed below.


Human    52 VPEEMNTTSH----------HIGQLRSDLDNGNNSFQYKLLGAGAGST---FIIDERTGDIYAIQ 103
            :.|||....|          .:..:.:|.|...|...|:::|...|..   |.|||.||:|:..:
 Worm  1220 IDEEMTPNEHLEKTNGKPIVTVKAIDTDSDGPQNEVHYRIVGEANGEETKHFRIDELTGEIFPNE 1284

Human   104 KLDREERSLYILRAQVIDIATGRAVE-------PESEFV---IKVSDINDNEPKFLDEPYEAIVP 158
            |.|||:..:|||..:    |:.|:|.       |..:.|   |.::|:|||.|.|.::.|...|.
 Worm  1285 KFDREKIDMYILTVE----ASDRSVSALPGANGPNKDNVKVQIVINDVNDNAPSFEEQKYIGRVK 1345

Human   159 EMSPEGTLVIQVTASDADDPSSGNNARLLYSLL---QGQPYFSVEPTTGVIRISSKMDRELQDEY 220
            |...||..||.:.|.|.|     .::.|.|.|:   .|:..|.|...:|.|.:...:|.|..|:|
 Worm  1346 ESEGEGHDVITIKAHDLD-----KHSNLRYHLIGAGGGRIPFGVRTDSGTIFVKEPLDFEASDQY 1405

Human   221 WVIIQAKDMIGQPGALSGTTSVLIKLSDVNDNKPIFKESLYRLTV-SESAPTGTSIGTIMAYDND 284
            .:::.|.|     |..:.||:|.|.:.|||||.|.|::..|..|| .|.......:..:.|.|.|
 Worm  1406 HLVLIASD-----GRHNATTNVYIHIEDVNDNAPQFEQQKYATTVIEEDVDIPKVLFNVHATDAD 1465

Human   285 IGE-NAEMDYSIEEDDSQTFDIITNHETQEGIVILKKKVDFEHQNHYGIRAKVKNHHVPEQLMKY 348
            ..| ::.:.|.:|   .|..|.:.......|.:.|.|.:|.:..      |.|.:.:...|.:..
 Worm  1466 QDEKSSRIVYRLE---GQGADEVFRIGKYSGTIELVKALDRDPP------AGVPSWNFVVQAIDD 1521

Human   349 HTEASTTF--IKIQVEDV-DEPPLFLLPYYVFEVFEETPQ-----GSFVGVVSA---TDPDNRKS 402
            .......:  :::.|.|: |..|:|  |..:|...||..:     |.:...|.|   .||....:
 Worm  1522 DGNGLVGYADVQVNVRDINDNSPIF--PERLFGYIEENREPIHSDGVYFMDVQARDFDDPTTENA 1584

Human   403 PIRYSITRSK------VFNINDN-GTITTSNSLDREISA--WYNLSITATEKYNIEQISSIPLYV 458
            .|.|.|.|:|      ||.|:.| |.|....|||||||:  .:.:.:.|.::....:.....:.:
 Worm  1585 NIEYGIVRNKLINGESVFRIDQNTGKIFAMRSLDREISSEREFIIEVRANDRGVPSREGFANVTI 1649

Human   459 QVLNINDHAPEFSQ-YYETYVCENAGSGQVIQTISAVDRDESIEEHHFYFNLSVE---------- 512
            :|.::||:||.|.: .||..|.|.|..|..:.:.||.|.||..:::.|.:.||.|          
 Worm  1650 KVTDMNDNAPFFEKTRYEGSVEETAPIGAAVMSFSAFDADEEAKDNVFTYQLSEESDYFYVTTDK 1714

Human   513 DTNNSSFTI------IDNQDNTAVILTNRTGFNL---------QEEPVFYISILIADNGIPSL-- 560
            |:..||..:      :|.:|     :|.|.||:|         ..|...:::::..::..|.:  
 Worm  1715 DSKQSSVGVLRVKQPLDYED-----VTQRDGFHLGIRVSDGRHDAEAAVHVALVDRNDHAPHIHG 1774

Human   561 -------------TSTNTLTIHVCDCGDS 576
                         ||....|....|.||:
 Worm  1775 ATEHRVREDVPRGTSIGRYTATDRDAGDT 1803

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CDH19NP_066976.1 Cadherin_repeat 49..144 CDD:206637 32/114 (28%)
Cadherin_repeat 152..252 CDD:206637 32/102 (31%)
Cadherin_repeat 261..366 CDD:206637 21/109 (19%)
Cadherin_repeat 375..466 CDD:206637 29/107 (27%)
Cadherin_repeat 474..572 CDD:206637 30/137 (22%)
CADH_Y-type_LIR 706..765 CDD:460041
hmr-1NP_001021650.1 Cadherin_repeat 431..521 CDD:206637
Cadherin_repeat 534..638 CDD:206637
Cadherin_repeat 647..742 CDD:206637
Cadherin_repeat 752..861 CDD:206637
Cadherin_repeat 875..975 CDD:206637
Cadherin_repeat 983..1085 CDD:206637
Cadherin_repeat 1103..1206 CDD:206637
Cadherin_repeat 1216..1331 CDD:206637 32/114 (28%)
Cadherin_repeat 1340..1432 CDD:206637 32/101 (32%)
Cadherin_repeat 1443..1542 CDD:206637 20/107 (19%)
Cadherin_repeat 1553..1657 CDD:206637 28/103 (27%)
Cadherin_repeat 1666..1768 CDD:206637 26/106 (25%)
Cadherin_repeat 1779..1868 CDD:206637 6/25 (24%)
EGF_CA 2250..2283 CDD:238011
LamG 2286..2459 CDD:238058
LamG 2533..2679 CDD:473984
Blue background indicates that the domain is not in the aligned region.

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