Protein Alignment CDH19 and cdh19

DIOPT Version :10

• Sequence 1: NP_066976.1
• Gene: CDH19 / 28513
• HGNCID: 1758
• Length: 772
• Species: Homo sapiens
• Sequence 2: XP_031760338.1
• Gene: cdh19 / 100493723
• XenbaseID: XB-GENE-6045915
• Length: 780
• Species: Xenopus tropicalis
• Alignment Length: 722
• Identity: 393/722 - (54%)
• Similarity: 517/722 - (71%)
• Gaps: 12/722 - (1%)

Human    32 KQPVRSHLRVKRGWVWNQFFVPEEMNTTSH-HIGQLRSDLDNGNNSFQYKLLGAGAGSTFIIDER 95
            |.....|.|.||||:||.|:|.||...|.. :||||:||||..:.||:|.|||.||.:.|.||||
 Frog    33 KDQTSYHRRAKRGWLWNPFYVLEEQEITEPLYIGQLKSDLDKQDGSFKYILLGDGAKTIFTIDER 97

Human    96 TGDIYAIQKLDREERSLYILRAQVIDIATGRAVEPESEFVIKVSDINDNEPKFLDEPYEAIVPEM 160
            ||.||.::||||||:|.|.||||.|:..||..||.||||::||.|||||||||::|||.|.||||
 Frog    98 TGKIYLLKKLDREEKSSYTLRAQAINTVTGVPVEAESEFIVKVQDINDNEPKFINEPYFATVPEM 162

Human   161 SPEGTLVIQVTASDADDPSSGNNARLLYSLLQGQPYFSVEPTTGVIRISSKMDRELQDEYWVIIQ 225
            |||||.|.||||:|.|||:.||:|||:||:|||||:||:||.:|:||:.|:||||.:|.|:|:||
 Frog   163 SPEGTFVTQVTATDMDDPNYGNSARLVYSILQGQPHFSIEPKSGIIRVVSQMDREAKDLYFVVIQ 227

Human   226 AKDMIGQPGALSGTTSVLIKLSDVNDNKPIFKESLYRLTVSESAPTGTSIGTIMAYDNDIGENAE 290
            ||||.|..|.||.||:|.:.|||||||.|.|::.:|.:::.|::..|..:|.:||.|.|||:|||
 Frog   228 AKDMAGSVGGLSTTTTVTVSLSDVNDNAPKFQQKIYDMSILETSLVGEIVGMVMADDRDIGKNAE 292

Human   291 MDYSIEE-DDSQTFDIITNHETQEGIVILKKKVDFEHQNHYGIRAKVKNHHVPEQLMKYHTEAST 354
            |.|.||| .|...|||||::.|||||:||:|.:|:|.:..|.||.|..|.|:.|:.:|:.....|
 Frog   293 MTYKIEEKGDFSIFDIITDNLTQEGIIILRKTLDYESKKRYSIRVKAINKHIDERFLKHGLFEDT 357

Human   355 TFIKIQVEDVDEPPLFLLPYYVFEVFEETPQGSFVGVVSATDPDNRKSPIRYSITRSK---VFNI 416
            |.:||.|||:|||.:|.|..|..|:.|..|.||:||.|:|.||||..:|:||.:.:||   :|.|
 Frog   358 TTVKIHVEDIDEPAVFGLKEYFMEILENAPTGSYVGSVTAKDPDNINTPVRYGLHQSKHVGLFYI 422

Human   417 NDN-GTITTSNSLDREISAWYNLSITATEKYNIEQISSIPLYVQVLNINDHAPEFSQYYETYVCE 480
            :.: |.|||:..||||.:.|||:::||||..|...:|.:|:|::::::||:||:.|:.|..||||
 Frog   423 DLHLGAITTTKPLDREEALWYNVTVTATEATNSAHVSEVPVYIRIIDVNDNAPQLSEEYRIYVCE 487

Human   481 NAGSGQVIQTISAVDRDESIEEHHFYFNLSVEDTNNSSFTIIDNQDNTAVILTNRTGFNLQEEPV 545
            .:...:.||.||||||||:.....|.|.|..|.:||::||:.||:||||.|...|..|||.|.|.
 Frog   488 QSKPREPIQIISAVDRDEATAGQQFSFTLLPEASNNTNFTVRDNKDNTATIYALRDEFNLHETPH 552

Human   546 FYISILIADNGIPSLTSTNTLTIHVCDCGDSGSTQTCQYQELVLSMGFKTEVIIAILIC--IMII 608
            ||..|:|.|||||.|:|||||||||||||..|:|:.|:...:.|.:|.....:|||.:|  ::::
 Frog   553 FYFEIVINDNGIPPLSSTNTLTIHVCDCGVDGNTEFCKDNGMFLYLGLNFGALIAIGVCSFLILV 617

Human   609 FGFIFLTLGLKQRRKQILFPEKSEDFRENIFQYDDEGGGEEDTEAFDIAELRSSTIMRERKTR-K 672
            .|||.|   :|.::|.....||||||||||.:||||||||||||||||..|.:..|:|::|.| :
 Frog   618 LGFILL---VKLKKKHTTLSEKSEDFRENIVKYDDEGGGEEDTEAFDIGHLTNQAILRKQKPRNR 679

Human   673 TTSAEIRSLYRQSLQVGPDSAIFRKFILEKLEEANTDPCAPPFDSLQTYAFEGTGSLAGSLSSLE 737
            ....:|:|.||.||::|||.|:|::|:||||||||.|..:.|.|||:||||||||||||||||:|
 Frog   680 RFRTDIQSFYRMSLKLGPDIAVFKEFLLEKLEEANEDIESLPLDSLKTYAFEGTGSLAGSLSSIE 744

Human   738 SAVSDQD 744
            ||.||.|
 Frog   745 SAFSDID 751

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CDH19	NP_066976.1	Cadherin_repeat	49..144	CDD:206637	56/95 (59%)
		Cadherin_repeat	152..252	CDD:206637	66/99 (67%)
		Cadherin_repeat	261..366	CDD:206637	49/105 (47%)
		Cadherin_repeat	375..466	CDD:206637	41/94 (44%)
		Cadherin_repeat	474..572	CDD:206637	55/97 (57%)
		CADH_Y-type_LIR	706..765	CDD:460041	29/39 (74%)
cdh19	XP_031760338.1	Cadherin_repeat	51..146	CDD:206637	56/94 (60%)
		Cadherin_repeat	154..>233	CDD:206637	54/78 (69%)
		Cadherin_repeat	262..369	CDD:206637	49/106 (46%)
		Cadherin_repeat	377..473	CDD:206637	41/95 (43%)
		CA	499..580	CDD:214520	48/80 (60%)
		CADH_Y-type_LIR	713..>760	CDD:460041	29/39 (74%)