DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CCDC141 and zormin

DIOPT Version :9

Sequence 1:	XP_011509293.1	Gene:	CCDC141 / 285025	HGNCID:	26821	Length:	1558	Species:	Homo sapiens
Sequence 2:	NP_001261317.1	Gene:	zormin / 2769001	FlyBaseID:	FBgn0052311	Length:	3664	Species:	Drosophila melanogaster

Alignment Length:	1554	Identity:	304/1554 - (19%)
Similarity:	587/1554 - (37%)	Gaps:	301/1554 - (19%)

- Green bases have known domain annotations that are detailed below.

Human     2 SSQGSPSVALST-------------------------TTVSSVAVQAGDSKIVIAVIKCGKWVQL 41
            ||..:||.|:||                         ||:.:|.|:.|..::|||:::..:.:.:
  Fly    58 SSSPTPSQAMSTAMSTGTGTGTGTTHTTPPSSSSLRATTIGTVVVRCGPIQLVIALLQSPEKIYI 122

Human    42 QLAESQPNLLEIGSSQDETKKLLHDHELLLAKLKALEDRVWELLQEADKTAEENKDQSQVYDAMA 106
            ::.|.:|.:..:|.:.||:.::..:|:..|..|::|...:.|.:|:|||.....:..|::.:|||
  Fly   123 KVVELEPKITALGENLDESLRMQREHDETLRNLQSLPGPMDEFVQKADKLLASKRISSELVNAMA 187

Human   107 ETLGEAWAALVSMLERRTELLRLTSEFFENALEFAIKIDQAEDFLQNTHEFESAESLKSLLQLHE 171
            :||...|..::::|:.|..||.|.::|.:...:...|:||.|...:.|........::..|...:
  Fly   188 DTLNIIWQDILNLLQDRQHLLILCTQFHDKMTQCFRKMDQLELACEETLHPPDVPRVQEFLNRFK 252

Human   172 HHTKELLERSLALLNKSQQLTDFIEKF-KCEGPNVNPE-----LTQGAHSSCLKVDRLLELLQDR 230
            ....::|...:|.|....:|...:|:. |.|..:..||     .|:..|    :|.:.||.|.||
  Fly   253 QLRIDMLTGVMAALKDGNELLAQLEELEKLETLDTRPEHIKRDATRAVH----QVQQWLEALHDR 313

Human   231 RRQLDKYLKQQWQ----ELSQVLQICQWDQQENQVTCWFQKTIRNLQEQSLGSSLSDNEDRIHKQ 291
            |..|:    ..||    ::.|.|.:....::...:....|:....|...   .||.:.|   |..
  Fly   314 RNSLE----LAWQTRKIQMEQCLALALLGRELVDLEAALQQARMELNTM---YSLGECE---HTA 368

Human   292 EELIIKAKEWNSAVEKLKSEALRILLSKD-------YVEKEHLQLSHQKLSQLQEEFGQLMVERN 349
            .|::.|.:||......|:..||:|..:|:       :.|::....::..||...|.. .|:.:|.
  Fly   369 NEMLTKYREWKQQALLLRDRALKITRAKEKVQSAGHFTEEDACARAYAVLSGCTEHL-DLVDQRE 432

Human   350 TWLKKANEFFNSANKAFDVLGRVEAYLKLLKSEGLSLAVLAVRHEELHRKIKDCTTDALQKGQTL 414
            .||.::.|||..|.....||.::|..|..:|....|....|: ..::.|.:::.|.:.|:.|..:
  Fly   433 HWLHQSREFFAKAEHTVSVLEKLELELTSVKLPPHSPESYAM-FSKVDRDVRNFTEEPLRLGYGI 496

Human   415 ISQVDSCSSQVSGIHEMMGCIKRRVDHLTEQCSAHKEYALKKQQLTASVEGY----LRKVEMSIQ 475
            :.:|.....:..|:..::..::.|..::...|:...|...|.|:..:....:    |..:..|.|
  Fly   497 LDEVGRTQPETQGVKRVLDELENRKVYIQGICANSSEDQQKVQRALSEFLNHHNELLAWLRASGQ 561

Human   476 KISPVLSNAMDVGSTRSESEKILNKYLEL--DIQAK-ETSHELEAAAKTMMEKNEFVSDEMVSLS 537
            .   .|..::|:|....::::.|.::.||  |::.| |..:.|..:.|..:|  .....|...:.
  Fly   562 H---QLQQSVDMGGNLQQAKQFLLQHHELMQDLEIKGELINLLLESIKVHLE--SLSPQERYDVD 621

Human   538 SKA-----RWLAEELNLFGQSIDYRSQVLQTYVAFLKSSEEVEMQFQSLKEFYETEIPQKEQDDA 597
            |||     .|: |..:|..:.:||.|.::.    |.:.:.|:..|..:|         |::....
  Fly   622 SKAESLHKHWI-ELKDLVLKRVDYVSLLID----FFELANELSSQLDNL---------QRQLQQT 672

Human   598 KAKHCSDSAEKQWQLFLKKSFITQDLGLEFLNLINMAKENEILDVKNEVYLMKNTMENQKAEREE 662
            ..:|.....:..|..........:..|..|:||..:   :..|:.|:....::.|:.:....:.:
  Fly   673 PDEHKLQFLQATWTGIASTFGELKSRGQRFINLKIV---DPYLETKSSAQAVQETLNDFSKRQVD 734

Human   663 LSLLRLAWQLKATESKPGKQQWAAFKEQLKKTSHNLKLLQEALMPVSALDLGGSLQFILDLRQKW 727
            ::.....|.....|.:..:..........::|......:...|.||.......|.|.::..|:|.
  Fly   735 VTSSLENWTTSIAEKREVEYLLEKVMSDNEETVAKSTQVDTQLYPVFTSQSVDSKQLLISTREKL 799

Human   728 NDMKPQFQQLNDEVQYIMKESEELTGRGAPVKEKSQQLKDLIHFHQKQKERIQ-DYEDILYKVVQ 791
            .::....::..||:|..::.:..:..:..|...|.:|:.:.:...:.:.:.|: ||..::..|:|
  Fly   800 TNVIQDIERAQDEIQQRIQTTLGIQTKDQPSLAKIEQVINNLRMLKAKLDGIKYDYRTLVESVIQ 864

Human   792 FHQVKEELGRLIKSRELEFVEQPKELGDAHDVQIHLRCSQEKQAR---VDHLHRLAL--SLGVDI 851
            |   .|.:.:|.:..:..|..|.||.....|..|    ::.::.|   :|....|..  .|.:|.
  Fly   865 F---LENIVQLRREIDDYFARQQKEPASGADRSI----AEHEKFRDQCMDKFRSLITQSELLIDR 922

Human   852 ISSVQRPHCSNVSAKNLQQQLELLEEDSMKWRAKAEEYGRTLSRSVEYCAMRDEINELKDSFKDI 916
            :..::.|....:....:   |:|||...:.:.:.:.....||.|..:....|.::.::..|...:
  Fly   923 VRVLEPPGAREIDTDRI---LKLLENLRLHFESNSSARMSTLERLEKIEQFRSDLEDIDRSLDSV 984

Human   917 KK----------------KFNNLKFNYTKKN---EKSRNLKALKYQIQQVDMYAEKMQALKRKME 962
            .:                |..:|.|.|.::.   ...|.||:.::| ::....|..::.|::::|
  Fly   985 SQQLHEINNQSVDSLAAAKTTSLAFEYFERTIECSMPRQLKSTRHQ-RRWGQTAHTIELLEKRIE 1048

Human   963 KVSNKTSDS-FLNYPSDKVNVLLEVMKDLQKHVDDFDKVVTDYKKNLDLTEHFQEVIEECHFWYE 1026
            |.:..||.. |:..|..:..|..|:.| |.:....|...|...:|:|:....|.||:|:....|.
  Fly  1049 KFTESTSQQLFITNPESERYVKDELRK-LNEKWQSFKDQVKQKRKSLNQATDFFEVVEKIDAEYR 1112

Human  1027 DASATVVRVGKYSTECKTKEAVKILHQQFNKFIAPSVPQQEERIQEATDLAQHLYGLEEGQKYIE 1091
            :.|                        .|...::..||...:.: ||.:|...          ||
  Fly  1113 EIS------------------------YFYTSVSNKVPYLRDSV-EAGNLVND----------IE 1142

Human  1092 KIVTKHKEVLESVTELCESLTELEEKLKQGDVLKMNPNLEDFHYDYIDLLKEPAKNK-QTIFNEE 1155
            ..||..:..|.|                     |::...:..|    |:      || .:::|:.
  Fly  1143 NYVTSREAALRS---------------------KLDSASQCAH----DM------NKVSSLYNDV 1176

Human  1156 RNKGQVQVADLLGINGTGEERLPQDLKVSTDKEGGVQDLLLPEDMLSGEEYECVSPDDISLPPLP 1220
            .|..|..:...:.|| ..:|||.|:.:....:|...:|
  Fly  1177 MNIFQSFIKLKMDIN-VVQERLKQEQRQKEQRERDARD--------------------------- 1213

Human  1221 GSPESPLAPSDMEVEEPVSSSLSLHISSYGVQAGTSSPGDAQESVLPPPVAFADACNDKRETFSS 1285
             ..|...|..:.|.:|      .||                                  ||. .|
  Fly  1214 -QAEREKAIKEAEAKE------RLH----------------------------------REE-QS 1236

Human  1286 HFERPYLQFKAEPPLTSRGFVEKSTALHRISAEHPESMMSEVHERALQQHPQAQGGLLETREKMH 1350
            ..|....|...|.  ..|....:..||...:....|:.:..:.|:|.::....:....|...::.
  Fly  1237 RLENQRQQAAIEQ--AQRELAARELALREQAVREEEARLQAIREQATREQLAREQAAREEELRIQ 1299

Human  1351 ADNNFTKTQD--RLHASSDAFSGLRFQ---------SGTSRGYQRQMVPREEI------------ 1392
            :..:..:.::  ||....|..:.:|.:         ...|:..:...:.||||
  Fly  1300 SLRDIARREEEVRLQNIRDEETRIRREEEERIRRENESRSKREEEARIQREEITRLQTLRDQVDQ 1364

Human  1393 ---------KSTSAKSSVVSLADQAPNFSRLLSNVTVMEGSPVTLEVEVTGFPEPTLTW 1442
                     |.....|....|...:|.|:|.|.:....||.....|.||||.|||.:.|
  Fly  1365 QRIVTENIRKDIQVNSIFTELRYASPLFTRPLKDAVSREGDRFVFECEVTGTPEPAVEW 1423

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCDC141	XP_011509293.1	SPEC	132..356	CDD:238103	53/240 (22%)
CCDC141	XP_011509293.1	SMC_prok_B	221..>846	CDD:274008	128/653 (20%)
zormin	NP_001261317.1	SPEC	126..332	CDD:238103	55/213 (26%)
		SPEC	<504..641	CDD:295325	28/142 (20%)
		COG1340	960..1298	CDD:224259	82/477 (17%)
		RILP-like	<1190..1315	CDD:304877	29/196 (15%)
		MAP7	1233..1365	CDD:283355	21/134 (16%)
		I-set	1390..1479	CDD:254352	15/34 (44%)
		IGc2	1403..1469	CDD:197706	11/21 (52%)
		I-set	1491..1580	CDD:254352
		IGc2	1504..1570	CDD:197706
		I-set	1589..1675	CDD:254352
		Ig	1605..1675	CDD:299845
		I-set	1702..1786	CDD:254352
		Ig	1713..1786	CDD:299845
		I-set	1811..1902	CDD:254352
		Ig	1828..1892	CDD:143165
		I-set	1927..2015	CDD:254352
		IGc2	1940..2005	CDD:197706
		I-set	2142..2231	CDD:254352
		Ig	2158..2231	CDD:299845
		I-set	2238..2325	CDD:254352
		Ig	2254..2324	CDD:299845
		I-set	3566..3655	CDD:254352
		Ig	3583..3650	CDD:143165
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	189	1.000	Domainoid score	I3306
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	234	1.000	Inparanoid score	I3410
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5532
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.960