DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RNF149 and rnf149

DIOPT Version :9

Sequence 1:	XP_005263977.1	Gene:	RNF149 / 284996	HGNCID:	23137	Length:	428	Species:	Homo sapiens
Sequence 2:	XP_012812754.1	Gene:	rnf149 / 780151	XenbaseID:	XB-GENE-972101	Length:	398	Species:	Xenopus tropicalis

Alignment Length:	382	Identity:	235/382 - (61%)
Similarity:	280/382 - (73%)	Gaps:	19/382 - (4%)

- Green bases have known domain annotations that are detailed below.

Human    21 LALALC--VPGARGRALEWFSAVVNIEYVDPQTNLTVWSVSESGRFGDSSPKEGAHGLVGVPWAP 83
            |..|||  ..|:..|:||||:|:|..||.:|.||.||...:||||:||||||:...||||.|..|
Frog     7 LCSALCALTHGSSARSLEWFTALVRTEYTEPLTNSTVTGSTESGRYGDSSPKDTVQGLVGYPRDP 71

Human    84 GGDLEGCAPDTRFFVPEPGGRGAAP-----WVALVARGGCTFKDKVLVAARRNASAVVLYNEERY 143
             ..||||.|||::.||   |..|:|     |:||:||||||||:||..||.|.|||||:|||.:.
Frog    72 -WQLEGCHPDTQYIVP---GMPASPAPDSDWIALIARGGCTFKEKVFNAANRGASAVVIYNEAKS 132

Human   144 GNITLPMSH-------AGTGNIVVIMISYPKGREILELVQKGIPVTMTIGVGTRHVQEFISGQSV 201
            ||.|:.|||       .||||.||||:|||||.||||.:::.|||.|.|.:||||||||||||||
Frog   133 GNATVSMSHLESMDTSEGTGNTVVIMVSYPKGMEILEPMRRDIPVKMVITMGTRHVQEFISGQSV 197

Human   202 VFVAIAFITMMIISLAWLIFYYIQRFLYTGSQIGSQSHRKETKKVIGQLLLHTVKHGEKGIDVDA 266
            ||||||||||||||||||||||||||||||:|.|:||:||||||.|.||.||.||.||||||:||
Frog   198 VFVAIAFITMMIISLAWLIFYYIQRFLYTGAQCGNQSNRKETKKAISQLQLHRVKKGEKGIDIDA 262

Human   267 ENCAVCIENFKVKDIIRILPCKHIFHRICIDPWLLDHRTCPMCKLDVIKALGYWGEPGDVQEMPA 331
            |||||||||:|.||::|||||||||||:||||||::||||||||||||||||:|.||.:..::..
Frog   263 ENCAVCIENYKTKDLVRILPCKHIFHRLCIDPWLIEHRTCPMCKLDVIKALGFWVEPEETVDIHV 327

Human   332 PESPPGRDPAANLSLALPDDDGSDDSSPPSASPAESEPQCDPSFKGDAGENTALLGE 388
            |.|..|...:........::..|:.::.||:|...|..|.: |.|.||||.||||.:
Frog   328 PVSIAGSSLSIGTVSITQEESRSEGNNLPSSSTGSSLQQSN-SVKEDAGETTALLDD 383

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RNF149	XP_005263977.1	PA_GRAIL_like	43..185	CDD:239037	86/153 (56%)
		UPF0233	<204..>235	CDD:299753	29/30 (97%)
		zf-RING_2	267..310	CDD:290367	35/42 (83%)
rnf149	XP_012812754.1	PA_GRAIL_like	34..181	CDD:239037	85/150 (57%)
		UPF0233	<200..>220	CDD:299753	19/19 (100%)
		zf-RING_2	263..306	CDD:290367	35/42 (83%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	96	1.000	Domainoid score	I30844
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H18337
Inparanoid	1	1.050	453	1.000	Inparanoid score	I8351
NCBI	1	1.000	-	-
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1487241at2759
OrthoFinder	1	1.000	-	-		FOG0000832
OrthoInspector	1	1.000	-	-		oto159671
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X295
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.060