DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RNF149 and rnf130

DIOPT Version :9

Sequence 1:	XP_005263977.1	Gene:	RNF149 / 284996	HGNCID:	23137	Length:	428	Species:	Homo sapiens
Sequence 2:	XP_009289393.1	Gene:	rnf130 / 553950	ZFINID:	ZDB-GENE-050522-525	Length:	428	Species:	Danio rerio

Alignment Length:	421	Identity:	162/421 - (38%)
Similarity:	234/421 - (55%)	Gaps:	33/421 - (7%)

- Green bases have known domain annotations that are detailed below.

Human     5 RREASVGARGVLALALLALALCVP------GARGRAL---EWFSAVVNIEYVDPQTNLTVWSVSE 60
            :|.|:..:.....|||| ||...|      ||....:   :::||:||...:|.:.|........
Zfish     3 KRLAAPASCSSCLLALL-LAFVSPRCSLSIGADKTMVNKEDYYSAIVNATVLDHKGNPQQMVTKN 66

Human    61 SGRFGDSSPKEGAHGLVGVPWAPGG--DLEGCAPDTRFFVPEPGGRGAAPWVALVARGGCTFKDK 123
            .||:|.:|||..|.|:|..|.|..|  ||:||.|.|||.||..    ...|||::.||.||||:|
Zfish    67 DGRYGQNSPKTEAKGIVVAPAAVNGAVDLQGCCPHTRFIVPPK----TTHWVAIMQRGKCTFKEK 127

Human   124 VLVAARRNASAVVLYNEERYGNITLPMSHAGTGNIVVIMISYPKGREILELVQKGIPVTMTIGVG 188
            :|.||..|||||::||.....: |:.|:|.|||:||.:||:...|:|||..::|...|.:::.||
Zfish   128 ILKAAAFNASAVIIYNNNTKED-TVTMAHEGTGDIVAVMITESFGKEILGFLEKNQTVLVSVIVG 191

Human   189 TRHVQEFISGQSVVFVAIAFITMMIISLAWLIFYYIQRFLYTGSQIGSQSHRKE-TKKVIGQLLL 252
            :|.:.:.|:..|:|||:|:||.:||||.||||||:||:...|.::..||....: .||.|.:|..
Zfish   192 SRGMPKNINRGSLVFVSISFIVLMIISSAWLIFYFIQKIRDTSARDRSQRRLGDAAKKAISKLTT 256

Human   253 HTVKHGEKGIDVDAENCAVCIENFKVKDIIRILPCKHIFHRICIDPWLLDHRTCPMCKLDVIKAL 317
            .|||.|:|..:.|..:||||||.:::.|::|||||||:||::|:||||.:|.|||||||:::|||
Zfish   257 RTVKRGDKETEPDFNHCAVCIEGYQLNDVVRILPCKHVFHKMCVDPWLNEHCTCPMCKLNILKAL 321

Human   318 GYWGEPGDVQEMPAPESPPGRDPAANLSLALPD-DDGSDDSSPPSASPAESEPQCDPSFKGDAGE 381
            |.......|..|........|...::...||.| ...:..|..|....:.|:...|......:||
Zfish   322 GVMPNLPCVDNMAFDMDRMSRSQTSSQRTALVDLSSETSISLEPLRHSSSSQLPSDEELIPRSGE 386

Human   382 -NTALLGERCANYKTIECGQEWWLTPVISVL 411
             |.|:.             :||::.....||
Zfish   387 INIAVT-------------KEWFIVASFGVL 404

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RNF149	XP_005263977.1	PA_GRAIL_like	43..185	CDD:239037	61/143 (43%)
		UPF0233	<204..>235	CDD:299753	17/30 (57%)
		zf-RING_2	267..310	CDD:290367	26/42 (62%)
rnf130	XP_009289393.1	PA_GRAIL_like	49..188	CDD:239037	61/143 (43%)
rnf130	XP_009289393.1	zf-RING_2	271..314	CDD:290367	26/42 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1487241at2759
OrthoFinder	1	1.000	-	-		FOG0000832
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22765
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X295
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	6.020