DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RNF149 and gol

DIOPT Version :9

Sequence 1:	XP_005263977.1	Gene:	RNF149 / 284996	HGNCID:	23137	Length:	428	Species:	Homo sapiens
Sequence 2:	NP_001163300.1	Gene:	gol / 38006	FlyBaseID:	FBgn0004919	Length:	601	Species:	Drosophila melanogaster

Alignment Length:	321	Identity:	122/321 - (38%)
Similarity:	175/321 - (54%)	Gaps:	19/321 - (5%)

- Green bases have known domain annotations that are detailed below.

Human    40 AVVNIEYVDPQTNL-TVWSVSESGRFGDSSPKEGAHGLVGVPWAPG-GDLEGCAPDTRFFVPEPG 102
            |.:|..||:....| .:....|..|:|:.........|:.:..... .|...|.|..|..:..|.
  Fly    70 AFLNWSYVEHGNMLCNMEFAQEQARYGEGKVLNVTGRLIHITATDNFSDDYACTPYIRGTLGAPI 134

Human   103 GRGAAPWVALVARGGCTFKDKVLVAARRNASAVVLYNEERYGNITLPMSHAGTGNIVVIMISYPK 167
            ......|:|||.||.|||::||....::||:.|::||:::...:........|.||..::.....
  Fly   135 PDKGETWIALVRRGRCTFEEKVKHVYQQNAAGVIIYNDKQVMQLEKMQIKGKTRNIAAVITYQNI 199

Human   168 GREILELVQKGIPVTMTIGVGTRHVQEF--ISGQSVVFVAIAFITMMIISLAWLIFYYIQRFLYT 230
            |:::...:.||..||::|..|.|.|:..  ::..||:||:|:||.:|||||.||||||||||.|
  Fly   200 GQDLSLTLDKGYNVTISIIEGRRGVRTISSLNRTSVLFVSISFIVLMIISLVWLIFYYIQRFRY- 263

Human   231 GSQIGSQSHR---KETKKVIGQLLLHTVKHGEKGIDVDAENCAVCIENFKVKDIIRILPCKHIFH 292
             .|...|..|   ..|||.|.::...|.|..::. |:|::.||:|||.:|..|.||||||||.||
  Fly   264 -MQAKDQQSRNLCSVTKKAIMKIPTKTGKFSDEK-DLDSDCCAICIEAYKPTDTIRILPCKHEFH 326

Human   293 RICIDPWLLDHRTCPMCKLDVIKALGY--WGEPGDVQEMPAPESPPG------RDPAANLS 345
            :.||||||::|||||||||||:|..||  .|....:.|. .|:.|.|      ||.:|:|:
  Fly   327 KNCIDPWLIEHRTCPMCKLDVLKFYGYVFLGSEESILEY-QPDPPQGLALVEARDESADLN 386

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RNF149	XP_005263977.1	PA_GRAIL_like	43..185	CDD:239037	37/143 (26%)
		UPF0233	<204..>235	CDD:299753	21/30 (70%)
		zf-RING_2	267..310	CDD:290367	29/42 (69%)
gol	NP_001163300.1	PA_GRAIL_like	73..217	CDD:239037	37/143 (26%)
		UPF0233	226..>258	CDD:299753	17/31 (55%)
		zf-RING_2	301..344	CDD:290367	29/42 (69%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	87	1.000	Domainoid score	I7982
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	218	1.000	Inparanoid score	I3586
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1487241at2759
OrthoFinder	1	1.000	-	-		FOG0000832
OrthoInspector	1	1.000	-	-		otm41809
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22765
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X295
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	10	10.030