DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RNF149 and SPAC57A7.09

DIOPT Version :9

Sequence 1:	XP_005263977.1	Gene:	RNF149 / 284996	HGNCID:	23137	Length:	428	Species:	Homo sapiens
Sequence 2:	NP_593372.1	Gene:	SPAC57A7.09 / 2542187	PomBaseID:	SPAC57A7.09	Length:	372	Species:	Schizosaccharomyces pombe

Alignment Length:	383	Identity:	82/383 - (21%)
Similarity:	138/383 - (36%)	Gaps:	117/383 - (30%)

- Green bases have known domain annotations that are detailed below.

Human    15 VLALALLALAL------CVPGARGRALEWFSAVVNIEYVDPQTNLTVWSVSESGRFGDSSPKEGA 73
            ::.|.::||.|      .:|       :.|:|..::....|..|:|:|  |....||.......|
pombe    17 IILLEVIALDLGVLDNIFIP-------KRFAASTDVAIQLPDRNVTLW--SRQAVFGKHFTNASA 72

Human    74 HGLVGVPWAPGG---DLEGCA----PDTRFFV--------------------------PEPGGRG 105
            ..::.: :.|..   |:.||.    .|..:|.                          .:.||..
pombe    73 TTVINL-YLPSNFQEDMSGCPNRNDTDASYFYENDIIDYDIEYIEQKSYSSKPSARVQKDDGGES 136

Human   106 AAPWV---ALVARGGCTFKDKVLVAARRNASAVVLYNEE-------RY---------GNITLPMS 151
            ....:   .||.||.||:.||.|.|.|.....|::.:..       .|         ..:.:|..
pombe   137 KDEAILDFLLVQRGKCTYFDKALEAQRLGFKGVIVGDNRSPSSFRLHYMVAPDKVDESKVHIPSL 201

Human   152 HAGTGNIVV----IMISYPKGREILELVQKGIPVTMTIGVGTRHVQEFISGQSVVFV------AI 206
            ...|.:..:    ::.||   |:.|:|..|               .|.:......|:      .|
pombe   202 FVSTSSYNLLWSDLLHSY---RQPLKLYAK---------------PEELGDMFWPFLLCFSPSII 248

Human   207 AFITMMIISLAWLIFYY-----IQRFL-----YTGSQIGSQSHRKETKK-----VIGQLLLHTVK 256
            ..||:..:::...|..|     .:||:     .|.|:.|..|..:|.:.     .:..|:..:.:
pombe   249 MLITVQALAIRKFIRTYRTKSKTRRFIEDLPSRTISREGFYSEEEEIENSTQNGELVPLMDESTR 313

Human   257 HGEKGIDVDAENCAVCIENFKVKDIIRILPCKHIFHRICIDPWLLDHR-TCPMCKLDV 313
            ....|::     |.:|:|:|...|.:..|||||.|||.||..|::|:| .||.|..:|
pombe   314 RATFGVE-----CVICLESFTKGDKVVALPCKHEFHRPCIAKWIVDYRHACPTCNTEV 366

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RNF149	XP_005263977.1	PA_GRAIL_like	43..185	CDD:239037	37/197 (19%)
		UPF0233	<204..>235	CDD:299753	9/46 (20%)
		zf-RING_2	267..310	CDD:290367	20/43 (47%)
SPAC57A7.09	NP_593372.1	COG5540	1..369	CDD:227827	82/383 (21%)
		Peptidases_S8_S53	<144..211	CDD:299169	15/66 (23%)
		zf-RING_2	320..362	CDD:290367	20/46 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4628
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm53615
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810