DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SIRPB2 and CG13506

DIOPT Version :9

Sequence 1:	XP_005260765.1	Gene:	SIRPB2 / 284759	HGNCID:	16247	Length:	348	Species:	Homo sapiens
Sequence 2:	NP_001286718.1	Gene:	CG13506 / 37556	FlyBaseID:	FBgn0034723	Length:	503	Species:	Drosophila melanogaster

Alignment Length:	195	Identity:	50/195 - (25%)
Similarity:	79/195 - (40%)	Gaps:	35/195 - (17%)

- Green bases have known domain annotations that are detailed below.

Human   135 EHSEMKSDEGTSVL--VKGAGDPEPDLWIIQPQELVLGTTGDTVFLNCTVLGDGPPGPIRWFQGA 197
            |:.:...|:.|.::  .|...:.|...:.......|....||.|.|||..........:.|::
  Fly    44 EYGDDTDDDDTQIIDVTKNHAEQEAPPYFDVTDLRVEAKPGDDVILNCDARNFQLSNAVVWYK-- 106

Human   198 GLSREAIYNFGGISHPKETAVQASNNDFSILLQNVSSEDAGTYYCVKFQRKPNRQYLSGQGTSLK 262
              :|..|.|.   .:|....||...|: ||||:|||.||:..|||   :..|.|   ..|.|:|:
  Fly   107 --NRIIIANG---QNPISQRVQCMLNN-SILLRNVSPEDSDDYYC---EILPQR---VRQHTALR 159

Human   263 VKAK-STSSKEAEFTSEPATEMSPTGE------RTHL----------SGVNESPTGKGAMNGLVM 310
            |.|: |....:.:.|....|...  |:      ||:|          :.:|..|:.....||:::
  Fly   160 VGARLSILCDDRDITDRSQTFRQ--GDHHKLECRTYLPDNATIKWSFNDLNGQPSSVDNQNGVII 222

Human 311 310
Fly 223 222

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SIRPB2	XP_005260765.1	V-set	43..149	CDD:284989	3/15 (20%)
		IG_like	46..149	CDD:214653	3/15 (20%)
		V-set	163..263	CDD:284989	32/99 (32%)
		IG_like	168..243	CDD:214653	26/74 (35%)
CG13506	NP_001286718.1	IG_like	79..146	CDD:214653	27/77 (35%)
		IGc2	83..146	CDD:197706	26/73 (36%)
		IG_like	176..254	CDD:214653	9/49 (18%)
		Ig	176..239	CDD:299845	9/49 (18%)
		I-set	258..349	CDD:254352
		Ig	275..348	CDD:143165
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910