DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MCHR1 and AstC-R1

DIOPT Version :9

Sequence 1:	NP_005288.4	Gene:	MCHR1 / 2847	HGNCID:	4479	Length:	353	Species:	Homo sapiens
Sequence 2:	NP_649040.2	Gene:	AstC-R1 / 40020	FlyBaseID:	FBgn0036790	Length:	483	Species:	Drosophila melanogaster

Alignment Length:	329	Identity:	104/329 - (31%)
Similarity:	168/329 - (51%)	Gaps:	33/329 - (10%)

- Green bases have known domain annotations that are detailed below.

Human    13 NASNTSDGPDNLTSAGSPPRTGSI----SYINIIMPSVFGTICLLGIIGNSTVIFAVVKKSKLHW 73
            :.|:|....::|.....|.....|    |:.::....::|.:|::|:.||:.||:.|::.||:
  Fly    46 SGSSTIQPEESLYGTDLPTYQHCIATRNSFADLFTVVLYGFVCIIGLFGNTLVIYVVLRFSKM-- 108

Human    74 CNNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMA 138
             ..|.:|:|:||:|.|..||:|:||::: .|....|.|||.||.......:.:.|||:..|..|:
  Fly   109 -QTVTNIYILNLAVADECFLIGIPFLLY-TMRICSWRFGEFMCKAYMVSTSITSFTSSIFLLIMS 171

Human   139 IDRYLATVHPISSTKFRKPSVATLVICLLWALSFISITPVWLYARLIPFPGGA-VGCGIRLPNPD 202
            .|||:|..|||||.::|...:|.:|..:.|:.|.:.:.||.|||..:....|. ..|.|..|
  Fly   172 ADRYIAVCHPISSPRYRTLHIAKVVSAIAWSTSAVLMLPVILYASTVEQEDGINYSCNIMWP--- 233

Human   203 TDLY------WFTLYQFFLAFALPFVVITAAYVRILQRMTSSVAP---ASQRSIRLRTKRVTRTA 258
             |.|      .|.||.|||.||.|...|.:.|..::::: .||.|   ...:..|...::|||..
  Fly   234 -DAYKKHSGTTFILYTFFLGFATPLCFILSFYYLVIRKL-RSVGPKPGTKSKEKRRAHRKVTRLV 296

Human   259 IAICLVFFVCWAPYYVLQL-------TQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCE 316
            :.:..|:.:||.|:::.|:       .|..:||..:....|..|.:   |:||.:||.:|..|.|
  Fly   297 LTVISVYILCWLPHWISQVALIHSNPAQRDLSRLEILIFLLLGALV---YSNSAVNPILYAFLSE 358

Human   317 TFRK 320
            .|||
  Fly   359 NFRK 362

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MCHR1	NP_005288.4	7tmA_MCHR1	41..322	CDD:320460	98/297 (33%)
		TM helix 1	43..67	CDD:320460	8/23 (35%)
		TM helix 2	79..100	CDD:320460	11/20 (55%)
		TM helix 3	117..139	CDD:320460	5/21 (24%)
		TM helix 4	162..178	CDD:320460	3/15 (20%)
		TM helix 5	206..229	CDD:320460	11/28 (39%)
		TM helix 6	255..277	CDD:320460	6/21 (29%)
		TM helix 7	290..315	CDD:320460	8/24 (33%)
AstC-R1	NP_649040.2	7tm_4	88..368	CDD:304433	97/287 (34%)
AstC-R1	NP_649040.2	7tm_1	94..353	CDD:278431	89/270 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24229
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X22
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	4	3.970