Protein Alignment WDR62 and wdr62

DIOPT Version :10

• Sequence 1: NP_001077430.1
• Gene: WDR62 / 284403
• HGNCID: 24502
• Length: 1523
• Species: Homo sapiens
• Sequence 2: NP_001429277.1
• Gene: wdr62 / 570949
• ZFINID: ZDB-GENE-060503-291
• Length: 1520
• Species: Danio rerio
• Alignment Length: 1582
• Identity: 675/1582 - (42%)
• Similarity: 902/1582 - (57%)
• Gaps: 201/1582 - (12%)

Human    39 PICLRRRTRLSTASEETVQNRVSLEKVLGITAQNSSGLTCDPGTGHVAYLAGCVVVILDPKENKQ 103
            |...||:||.|  ....:.|||.|||||||||.:||.|||||.||.|||.||||:|||.||:|||
Zfish    32 PANTRRKTRQS--HRRDIHNRVVLEKVLGITASSSSALTCDPNTGLVAYPAGCVIVILSPKKNKQ 94

Human   104 QHIFNTARKSLSALAFSPDGKYIVTGENGHRPAVRIWDVEEKNQVAEMLGHKYGVACVAFSPNMK 168
            .|||||:||:.||||||.:|||:||||:||.|.||:|||.|:.||||:..|||||:|||||||..
Zfish    95 THIFNTSRKTFSALAFSQNGKYLVTGESGHMPCVRVWDVAERTQVAEVQCHKYGVSCVAFSPNGS 159

Human   169 HIVSMGYQHDMVLNVWDWKKDIVVASNKVSCRVIALSFSEDSSYFVTVGNRHVRFWFLEVSTETK 233
            :|||:|||||..::||:|||..|:||||||.||:.:|||||:|||||.|||||:||:|:.|.|.:
Zfish   160 YIVSVGYQHDRTVSVWEWKKGTVIASNKVSSRVLGVSFSEDNSYFVTAGNRHVKFWYLDASKERR 224

Human   234 VTSTVPLVGRSGILGELHNNIFCGVACGRGRMAGSTFCVSYSGLLCQFNEKRVLEKWINLKVSLS 298
            |.|||||:||||:|||..|:.|||:|||||.||.||:|::::|||||||..|.|:.|::||.:.:
Zfish   225 VNSTVPLIGRSGLLGEHQNSQFCGLACGRGSMASSTYCITHTGLLCQFNSNRQLDSWVDLKTTSA 289

Human   299 SCLCVSQELIFCGCTDGIVRIFQAHSLHYLANLPKPHYLGVDVAQGLEPSFLFHRKAEAVYPDTV 363
            .||.||...:||||.||.||:|....|.|:..|.:||.|||||:||.:|..||....||.||||:
Zfish   290 QCLSVSGTFVFCGCADGTVRVFSPQDLRYITTLHRPHCLGVDVSQGTQPGHLFSANPEAQYPDTL 354

Human   364 ALTFDPIHQWLSCVYKDHSIYIWDVKDINRVGKVWSELFHSSYVWNVEVYPEFED-QRACLPSGS 427
            ||||||:.:.|:|||.|||:|:|||:||..||||:|.|:||..||:||.|||.|| ..|||..||
Zfish   355 ALTFDPVTKHLTCVYNDHSVYVWDVRDIRNVGKVYSALYHSGCVWSVETYPELEDPSAACLSPGS 419

Human   428 FLTCSSDNTIRFWNLDSSPDSH-----WQKNIFSNTLLKVVYVENDIQHLQDMSHFPDRGSENGT 487
            |||||||||||.|. ..||.||     .:.|::|..::::|||::|.|:|:..:    ..:|.|.
Zfish   420 FLTCSSDNTIRLWR-SESPQSHSAGLGLRHNLYSQDIVRIVYVDDDTQYLKAEA----VKAEGGA 479

Human   488 PMDVKAGVRVMQVSPDGQHLASGDRSGNLRIHELHFMDELVKVEAHDAEVLCLEYSKPETGLTLL 552
            ..|.|:|:||:.:||||||||:|||||||||..|.|||||.|:||||:|||||.:|..||||.||
Zfish   480 GQDGKSGIRVLGISPDGQHLAAGDRSGNLRIFGLQFMDELQKIEAHDSEVLCLAFSPAETGLHLL 544

Human   553 ASASRDRLIHVLNVEKNYNLEQTLDDHSSSITAIKFAG-NRDIQMISCGADKSIYFRSAQQGSDG 616
            ||||||||||:.:::...||.||:.|||:||||:||.| |.::.|:|||||||:|||||::.|||
Zfish   545 ASASRDRLIHIFDMDSKCNLVQTVYDHSASITAVKFTGLNSELCMVSCGADKSVYFRSAEKTSDG 609

Human   617 LHFVRTHHVAEKTTLYDMDIDITQKYVAVACQDRNVRVYNTVNGKQKKCYKGSQGDEGSLLKVHV 681
            |.|.|:||:.|||||||||:|.|:.:.|:||||||:||||..:||.|||:|||..|:|:||||.:
Zfish   610 LVFSRSHHIVEKTTLYDMDLDATRTHTAIACQDRNIRVYNVKSGKMKKCFKGSMNDDGTLLKVQL 674

Human   682 DPSGTFLATSCSDKSISVIDFYSGECIAKMFGHSEIITSMKFTYDCHHLITVSGDSCVFIWHLGP 746
            ||||.|||||||||:|.|.|:.||||:|.:||||||:|.|||:.||.||||||||||||:|.|..
Zfish   675 DPSGMFLATSCSDKNICVFDYESGECVATLFGHSEIVTGMKFSQDCRHLITVSGDSCVFVWRLDS 739

Human   747 EITNCMKQHLLEIDHRQQQ-----QHTNDKKRSGHPRQDTYVSTPSEIHSLSPGEQTEDDLEEEC 806
            ::||.|::.|.|   |:||     |....|:..  .|::||::.|  .::|:..|  ||.|..|.
Zfish   740 QMTNSMRKRLAE---RKQQAGLRLQRAPTKQEV--IRRETYITVP--CNALTHME--EDGLMAEV 795

Human   807 EPEEML---KTPSK-DSLDP--DPRCLLTNGKLPLWAKRLLGDDDVADGLAFHAKRSYQPHGRWA 865
            .||:.|   :||.: ||.|.  |...|.||||:|:|.:||.|:.: .||.....:..|||.||||
Zfish   796 NPEDGLEDCRTPDRLDSTDASLDSVVLQTNGKMPMWVRRLGGEGE-KDGTGAANRVQYQPQGRWA 859

Human   866 ERAGQEPLKTILD--AQDLDCYFTP---MKPESLENSILDSLEPQSLASLL------SESESPQE 919
            .::....::|:|:  :..|....||   |..|.||..  ....||||.|||      .|.|..:|
Zfish   860 VQSDPLAIRTVLEMKSNQLPLSHTPSRVMGEEELEED--PRFHPQSLDSLLDEDLEDGEEEEEEE 922

Human   920 AGRGH-----------PSFL--PQQKE-------SSEASELILYSLEAEVTVTGTDSQYCRKEVE 964
            ...|.           |.||  |..:|       |||.:..|||...:....||......:...|
Zfish   923 KICGSSRDGFSSSLHGPEFLQFPHGEENFNPELSSSEKTGYILYPANSTALSTGEGEFDVKALCE 987

Human   965 AGPGDQQGDSYLRVSSDSPKDQSPPEDSGESEADLECSFAAIHSPAPPPDPAPRFATSLPHFPGC 1029
            ...||                  |.|:  |...|..||   ..||....|.        ||
Zfish   988 GTAGD------------------PDEE--ELSPDSACS---AESPESHSDQ--------PH---- 1017

Human  1030 AGPTEDELSLPEGPSVPSSSLPQTPEQE-KFLRHHFETLTESPCRELFPAALGDVEASEAEDHFF 1093
               .:|..||.:..|..||.:.:..|:. ..||.||:||..: ..|.|...|..::.: .|.:|.
Zfish  1018 ---DQDTDSLSQVSSTGSSGVEEDEEESGTLLRQHFDTLGVA-TNEKFNTDLSSLQPT-TESNFL 1077

Human  1094 NPRLSISTQFLSSLQKASRFTHTFPPRATQCLVKSP----EVKLMDRGGSQPRAGTGYASPDRTH 1154
            ||||||||:|||..|  ||| .:...|...||...|    :.:.:|:...:|:           |
Zfish  1078 NPRLSISTRFLSRFQ--SRF-RSAACRPAACLSSIPDESTDSQTLDQTMEKPK-----------H 1128

Human  1155 VLAAGKAEETLEAWRPPPPCLTSLASCVPASSVLP--------TDRNLPTPTSAPT-PGLAQGVH 1210
            :..:|..||..:........::|..|..|  |:|.        |::|..|..|..: ||:.....
Zfish  1129 LSNSGSVEEKEKTVIKRRSSMSSRRSSNP--SLLRWKNALGEITNKNQSTTQSTTSAPGVLSNKS 1191

Human  1211 APSTC---------SYMEATASSRARISRSISLGDSEGPIVATLAQPLRRPSSVGELASLGQELQ 1266
            ..::|         |||..||||||:|::|.|        |.:|...:...:.:..|.::....:
Zfish  1192 TSNSCDASVTRSRQSYMGPTASSRAKINQSNS--------VESLNLCISEETPLNALPNVEHSKE 1248

Human  1267 AITTATTPSLDSE--GQEPALRSWGNHEARANLRLTLSSACDGLLQP-PVDTQPGVTVPAVSFPA 1328
            .:...::|.:.|.  .|.|.|   |||.|||:|||.|.......|.| .:.::.|......|...
Zfish  1249 NMIPPSSPVVSSAPLHQSPVL---GNHSARASLRLDLIGHNRASLSPVSLKSRRGKVEHHDSPRR 1310

Human  1329 PSPVEESALRLHGSAFRPSLP------APE---SPGLPAHPSNPQLPEAR-------PGIPGGTA 1377
            .:.|..:.:|..|...|..:.      ||.   |.|......:|.:.:..       ..:.....
Zfish  1311 QALVTPTEMRSLGKESRKQISNIEQSLAPSDRLSTGAGMFARSPMVRQTSDTVFVDLQSVRSDQT 1375

Human  1378 SLLEPTSGALGLLQGSPARWSEPWVPVE-ALPPSPLELSRVGNILHRLQTTFQEALDLYRVLVSS 1441
            |:..|.:.|:.  |.:........:|.| .|....|.:.....:::.|..|..:|.|||..|.|.
Zfish  1376 SVSSPMTNAVS--QNNQDSADNNSIPEETGLSAEALSVQMCKEMVNELWHTIHKATDLYSKLCSI 1438

Human  1442 GQVDTGQQQARTELVSTFLWIHSQLEAECLVGTSVAPAQALPSPGPPSPPTLYPLA--SPDLQ-- 1502
            .::...|:|.:..|...|:.:.|:|.:.|            |....||..:.:|::  ||..|
Zfish  1439 PKLSEQQEQMKGVLQEVFVGVQSELNSIC------------PQKTQPSTKSTHPISEDSPGRQLR 1491

Human  1503 -----ALLEHYSELLVQAVRRK 1519
                 ||||.|||:|:..:..|
Zfish  1492 DDRAVALLEKYSEMLLLRMTEK 1513

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
WDR62	NP_001077430.1	WD40	42..567	CDD:441893	323/530 (61%)
		WD 1	109..150		27/40 (68%)
		WD40 repeat	114..153	CDD:293791	26/38 (68%)
		WD 2	153..194		26/40 (65%)
		WD40 repeat	159..197	CDD:293791	24/37 (65%)
		WD 3	196..234		25/37 (68%)
		WD40 repeat	201..239	CDD:293791	24/37 (65%)
		WD40 repeat	270..332	CDD:293791	28/61 (46%)
		WD 4	291..330		17/38 (45%)
		WD40 repeat	350..399	CDD:293791	31/48 (65%)
		WD 5	357..396		25/38 (66%)
		WD40	<364..744	CDD:441893	240/386 (62%)
		WD 6	402..450		32/53 (60%)
		WD40 repeat	407..442	CDD:293791	26/35 (74%)
		WD 7	490..529		28/38 (74%)
		WD40 repeat	498..532	CDD:293791	24/33 (73%)
		WD 8	532..574		27/41 (66%)
		WD40 repeat	538..578	CDD:293791	24/39 (62%)
		WD 9	578..618		27/40 (68%)
		WD40 repeat	583..620	CDD:293791	24/37 (65%)
		WD 10	626..665		25/38 (66%)
		WD40 repeat	632..667	CDD:293791	22/34 (65%)
		WD 11	671..713		27/41 (66%)
		WD40 repeat	676..712	CDD:293791	25/35 (71%)
		WD 12	714..752		26/37 (70%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	762..824		23/72 (32%)
		WD 13	803..846		20/48 (42%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	908..935		12/52 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	962..1055		20/92 (22%)
		WD 14	1137..1178		5/40 (13%)
		PHA03247	<1170..1413	CDD:223021	62/280 (22%)
		WD 15	1260..1298		11/39 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1344..1382		7/53 (13%)
wdr62	NP_001429277.1	None